Q721F4 (DAPEL_LISMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47

Gene names

Ordered Locus Names:

LMOf2365_1033

Organism

Listeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]

Taxonomic identifier

265669 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692
Catalytic activity	N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692
Sequence similarities	Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: HAMAP
Molecular_function	N-acetyldiaminopimelate deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692		PRO_0000376775
Sites
	Active site	68	1	By similarity
	Active site	127	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q721F4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 22966989A6C3E8D7	FASTA	371	41,515
	10 20 30 40 50 60 MLNEFIAIRR ELHQIPETGY KELKTQAYLL DYISKLPSEH LEVKKWRTGI LVLVKGTNPE 70 80 90 100 110 120 KTIGYRTDID ALPITEETGL PFASKHPGNM HACGHDLHMS IALGVLTHFA SKPAKDNLLF 130 140 150 160 170 180 VFQPAEEGPG GAKPIMESAE FAEWRPDSIY GLHIAPEYKV GEIAIKPGLL FANTSELFIS 190 200 210 220 230 240 FKGKGGHAAY PHLANDMVVA ASAFVGQMQT IISRNIDPMD SAVITIGRIH GGEIQNVIAE 250 260 270 280 290 300 TAYLDGTIRT LSPETMEIVW TRLKQLAKGW EEAYQCEVEF HPGSDYYQVD NDPVETEAFI 310 320 330 340 350 360 HFLEEQYPES YVPARSAMTG EDFGYFLSEI KGFMFWLGVD SEYSLHHAKL SPKEEAIPFA 370 IDVLIHFLES K

References

[1]

"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species." Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M. Nucleic Acids Res. 32:2386-2395(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: F2365.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017262 Genomic DNA. Translation: AAT03810.1.
RefSeq	YP_013633.1. NC_002973.6.
3D structure databases
HSSP	HSSP built from PDB template 1XMB based on UniProtKB P54970.
ProteinModelPortal	Q721F4.
ModBase	Search...
Protein-protein interaction databases
STRING	265669.LMOf2365_1033.
Protein family/group databases
MEROPS	M20.A27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAT03810; AAT03810; LMOf2365_1033.
GeneID	2799064.
KEGG	lmf:LMOf2365_1033.
PATRIC	20323295. VBILisMon105049_1037.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1473.
HOGENOM	HOG000241404.
KO	K05823.
OMA	YMLAEIP.
ProtClustDB	CLSK2753188.
Enzyme and pathway databases
UniPathway	UPA00034; UER00024.
Family and domain databases
HAMAP	MF_01692. DapEL.
InterPro	IPR023905. AcetylDAP_deacetylase. IPR017439. Amidohydrolase. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
PIRSF	PIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01891. amidohydrolases. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. False negative. PS00759. ARGE_DAPE_CPG2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPEL_LISMF

Accession

Primary (citable) accession number: Q721F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program