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Protein

Ribitol-5-phosphate cytidylyltransferase

Gene

tarI

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.UniRule annotation

Catalytic activityi

CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol.UniRule annotation

Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei14Transition state stabilizerUniRule annotation1
Sitei22Transition state stabilizerUniRule annotation1
Binding sitei111CTPUniRule annotation1
Sitei159Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1
Sitei216Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 10CTPUniRule annotation4
Nucleotide bindingi80 – 86CTPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Teichoic acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00790.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribitol-5-phosphate cytidylyltransferaseUniRule annotation (EC:2.7.7.40UniRule annotation)
Gene namesi
Name:tarIUniRule annotation
Ordered Locus Names:LMOf2365_1100
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000755861 – 237Ribitol-5-phosphate cytidylyltransferaseAdd BLAST237

Structurei

Secondary structure

1237
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi22 – 24Combined sources3
Beta strandi25 – 27Combined sources3
Helixi32 – 41Combined sources10
Beta strandi47 – 53Combined sources7
Helixi55 – 57Combined sources3
Helixi58 – 68Combined sources11
Beta strandi74 – 78Combined sources5
Helixi83 – 97Combined sources15
Beta strandi105 – 110Combined sources6
Helixi118 – 130Combined sources13
Beta strandi132 – 139Combined sources8
Beta strandi144 – 146Combined sources3
Beta strandi148 – 152Combined sources5
Helixi159 – 161Combined sources3
Beta strandi162 – 172Combined sources11
Helixi173 – 181Combined sources9
Helixi185 – 190Combined sources6
Helixi194 – 200Combined sources7
Beta strandi206 – 209Combined sources4
Helixi220 – 233Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F1CX-ray2.30A/B2-236[»]
ProteinModelPortaliQ720Y7.
SMRiQ720Y7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ720Y7.

Family & Domainsi

Sequence similaritiesi

Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiGACDTVI.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q720Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYAQILAGG KGTRMGNVSM PKQFLPLNGK PIIVHTVEKF ILNTRFDKIL
60 70 80 90 100
ISSPKEWMNH AEDNIKKYIS DDRIVVIEGG EDRNETIMNG IRFVEKTYGL
110 120 130 140 150
TDDDIIVTHD AVRPFLTHRI IEENIDAALE TGAVDTVIEA LDTIVESSNH
160 170 180 190 200
EVITDIPVRD HMYQGQTPQS FNMKKVFNHY QNLTPEKKQI LTDACKICLL
210 220 230
AGDDVKLVKG EIFNIKITTP YDLKVANAII QERIAND
Length:237
Mass (Da):26,793
Last modified:July 5, 2004 - v1
Checksum:i72A1EEA5300BE053
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT03877.1.
RefSeqiWP_003724626.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT03877; AAT03877; LMOf2365_1100.
KEGGilmf:LMOf2365_1100.
PATRICi20323436. VBILisMon105049_1107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT03877.1.
RefSeqiWP_003724626.1. NC_002973.6.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F1CX-ray2.30A/B2-236[»]
ProteinModelPortaliQ720Y7.
SMRiQ720Y7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi2799328.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT03877; AAT03877; LMOf2365_1100.
KEGGilmf:LMOf2365_1100.
PATRICi20323436. VBILisMon105049_1107.

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiGACDTVI.

Enzyme and pathway databases

UniPathwayiUPA00790.

Miscellaneous databases

EvolutionaryTraceiQ720Y7.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTARI_LISMF
AccessioniPrimary (citable) accession number: Q720Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.