Q71ZX4 (GCST_LISMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	LMOf2365_1365

Organism

Listeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]

Taxonomic identifier

265669 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_0000122568

Sequences

	Sequence		Length	Mass (Da)
	Q71ZX4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0B540A5DA2217546	FASTA	362	39,523
	10 20 30 40 50 60 MTELLKTPIH PLYAKYGAKT IDFGGWDLPV QFAGIKAEHE AVRTDAGLFD VSHMGEILVK 70 80 90 100 110 120 GPDSTSYLQY LLTNDIEKIK IGKAQYNIMC YETGGTVDDL VVYKKSETEY ILVVNAANTD 130 140 150 160 170 180 KDFEWMVKNI RGDVSVTNVS SEYGQLALQG PSAEKILAKL TDVDLSSISF FGFVEDADVA 190 200 210 220 230 240 GVKTIISRSG YTGEDGFEIY MPSADAGKVF EAILAEGVAP IGLGARDTLR LEAVLALYGQ 250 260 270 280 290 300 ELSKDITPLE AGLNFAVKLK KEADFIGKEA LIKQKEAGLN RKLVGIELIE RGIPRHDYPV 310 320 330 340 350 360 FLNEEEIGIV TSGTQSPTLG TNIGLALIDT AYTEIGQEVE VGIRNKKIKA KIVPTPFYKR AK

References

[1]

"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species." Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M. Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: F2365.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017262 Genomic DNA. Translation: AAT04140.1.
RefSeq	YP_013963.1. NC_002973.6.
3D structure databases
ProteinModelPortal	Q71ZX4.
SMR	Q71ZX4. Positions 4-360.
ModBase	Search...
Protein-protein interaction databases
STRING	Q71ZX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2799805.
GenomeReviews	Gene locus LMOf2365_1365 in contig AE017262_GR.
KEGG	lmf:LMOf2365_1365.
PATRIC	20323969. VBILisMon105049_1372.
TIGR	LMOf2365_1365.
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	MVKNIRG.
PhylomeDB	Q71ZX4.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	LMON265669:LMOF2365_1365-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_LISMF

Accession

Primary (citable) accession number: Q71ZX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program