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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  • glycine dehydrogenase (decarboxylating) activity Source: JCVI

GO - Biological processi

  • glycine decarboxylation via glycine cleavage system Source: JCVI
  • nucleoside metabolic process Source: InterPro

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Synonyms:gcvP1
Ordered Locus Names:LMOf2365_1366
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669661 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiQ71ZX3

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ71ZX3
SMRiQ71ZX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q71ZX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHRYLPMT EQDEKEMLDV IGVKSIDDLF QDIPEKIRFK RDYDLKPAKS
60 70 80 90 100
EPALLRELSK LASKNANTTE YASFLGAGVY SHYIPTVVDH VISRSEFYTA
110 120 130 140 150
YTPYQPEISQ GELQAIFEFQ TMIAELTGMD LANSSMYDGG TALAEAAMLA
160 170 180 190 200
SGHTKRKKIL ISGAVHPESS NVLKTYATGQ HIEVEVIPEL DGKTDIEALK
210 220 230 240 250
KALSDDIAGF VVQYPNFYGQ VEPLAELEKL VHENNSLLLV SSNPLSLGLL
260 270 280 290 300
TPPGEFGADI VVGDSQVFGI PESFGGPHCG FFAVTNKLMR KVPGRLVGET
310 320 330 340 350
VDENGKRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMATLGKT
360 370 380 390 400
GLVEMAKQNL DKSHYAKQKF REKGFEVLFS DGFFNEFVVK LSKPIKEVNE
410 420 430 440
SLLDEGIIGG YDLGFYEEKY ENHMLVAVTE MRTKEEIDAF VASLEGAK
Length:448
Mass (Da):49,499
Last modified:July 5, 2004 - v1
Checksum:i3330AC3BF5414A44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA Translation: AAT04141.1
RefSeqiWP_003726157.1, NC_002973.6

Genome annotation databases

EnsemblBacteriaiAAT04141; AAT04141; LMOf2365_1366
KEGGilmf:LMOf2365_1366

Similar proteinsi

Entry informationi

Entry nameiGCSPA_LISMF
AccessioniPrimary (citable) accession number: Q71ZX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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