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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: JCVI
  • manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  • phosphorus metabolic process Source: JCVI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:LMOf2365_1467
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585761 – 308Probable manganese-dependent inorganic pyrophosphataseAdd BLAST308

Structurei

3D structure databases

ProteinModelPortaliQ71ZM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71ZM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTLVFGHK NPDTDTICSA ISYAELKKAQ GADIEAVRLG ELNSETAFVL
60 70 80 90 100
DYFQVTAPRL VQTVANEVSE VALVDHNERQ QSVDDIDDVT VTAVVDHHRI
110 120 130 140 150
ANFETSDPLY YRAEPVGCTT TILLKMFREN EVEVSKTVAG LMLSAIISDT
160 170 180 190 200
LLFQSPTCTQ EDKVAAQKLA QIADVDIQSY GMEMLKAGAD VSKKTVAELL
210 220 230 240 250
LDAKEFNMND NKVEIAQINV VDVNDVLSRR AEVEALMTQN IVDKGLDLYL
260 270 280 290 300
FVITNILTND SVGIAIGSKT AVVEEAYGVK FVENQAPLKG VVSRKKQVVP

ILTDTFAK
Length:308
Mass (Da):33,760
Last modified:July 5, 2004 - v1
Checksum:i6767D483647EC309
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT04242.1.
RefSeqiWP_003725390.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT04242; AAT04242; LMOf2365_1467.
KEGGilmf:LMOf2365_1467.
PATRICi20324173. VBILisMon105049_1474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT04242.1.
RefSeqiWP_003725390.1. NC_002973.6.

3D structure databases

ProteinModelPortaliQ71ZM2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT04242; AAT04242; LMOf2365_1467.
KEGGilmf:LMOf2365_1467.
PATRICi20324173. VBILisMon105049_1474.

Phylogenomic databases

HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_LISMF
AccessioniPrimary (citable) accession number: Q71ZM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.