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Protein

L-lactate dehydrogenase 2

Gene

ldh2

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 2 (ldh2), L-lactate dehydrogenase 1 (ldh1)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90SubstrateUniRule annotation1
Binding sitei122NAD or substrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Active sitei177Proton acceptor1
Binding sitei230SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 40NADUniRule annotationAdd BLAST29

GO - Molecular functioni

  • L-lactate dehydrogenase activity Source: JCVI

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • L(+)-lactate biosynthetic process from pyruvate Source: JCVI

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 2UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 2UniRule annotation
Gene namesi
Name:ldh2UniRule annotation
Ordered Locus Names:LMOf2365_1553
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683641 – 311L-lactate dehydrogenase 2Add BLAST311

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ71ZD6.
SMRiQ71ZD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793.
KOiK00016.
OMAiSESCHGW.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q71ZD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD
60 70 80 90 100
AAAFMPGKMD ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI
110 120 130 140 150
VSSIVPEMMK GGFNGIFLIA TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD
160 170 180 190 200
TTRLRRLLAE KLDIAAQSID AFILGEHGDS QFPVWSHSSI YGKPVNEYSV
210 220 230 240 250
EKLGEALDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE ICRHIFSGSQ
260 270 280 290 300
RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EKEKEAFANS
310
VAVIKKSIQS I
Length:311
Mass (Da):33,783
Last modified:July 5, 2004 - v1
Checksum:i1B288BDBDC01DC07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT04328.1.
RefSeqiWP_003726645.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT04328; AAT04328; LMOf2365_1553.
KEGGilmf:LMOf2365_1553.

Similar proteinsi

Entry informationi

Entry nameiLDH2_LISMF
AccessioniPrimary (citable) accession number: Q71ZD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families