Q71Z78 (ARGB_LISMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	LMOf2365_1611

Organism

Listeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]

Taxonomic identifier

265669 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112628
Regions
	Region	41 – 42	2	Substrate binding By similarity
Sites
	Binding site	63	1	Substrate By similarity
	Binding site	156	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	215	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q71Z78 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8397A7F208DE2B26	FASTA	250	26,501
	10 20 30 40 50 60 MENTIVVKLG GVASDNLTED FFQQIIQWQA ANKKIVLVHG GGHYITKMMK SLAIPVETKN 70 80 90 100 110 120 GLRVTNKATL EVTKMVLIGQ VQPAITTAFQ KRNISVIGLN AGDTGLLEAD FLNDANLGFV 130 140 150 160 170 180 GKITKVKTDL IEQLLSENII TVIAPLGINS EYDWLNVNAD TAACEVASAL QAEALYLLTD 190 200 210 220 230 240 VPGVKKGSEI IGEIATDEIE KLQNAGVIKG GMIPKLASAA FAAENGVGKV IITDSLNTSG 250 TKIKNKVAIG

References

[1]

"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species." Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M. Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: F2365.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017262 Genomic DNA. Translation: AAT04386.1.
RefSeq	YP_014209.1. NC_002973.6.
3D structure databases
ProteinModelPortal	Q71Z78.
ModBase	Search...
Protein-protein interaction databases
STRING	Q71Z78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2799015.
GenomeReviews	Gene locus LMOf2365_1611 in contig AE017262_GR.
KEGG	lmf:LMOf2365_1611.
PATRIC	20324459. VBILisMon105049_1617.
TIGR	LMOf2365_1611.
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q71Z78.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	LMON265669:LMOF2365_1611-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_LISMF

Accession

Primary (citable) accession number: Q71Z78

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program