Q71YH8 (PYRB_LISMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	LMOf2365_1866

Organism

Listeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]

Taxonomic identifier

265669 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113156

Sequences

	Sequence		Length	Mass (Da)
	Q71YH8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9873FA6E02168957	FASTA	303	34,183
	10 20 30 40 50 60 MKNLLSMEAL TVHEIEHLLE QAAQFKRGKK ATFNEQTFAV NMFFEPSTRT HTSFEVAEKK 70 80 90 100 110 120 LGVEVVSFDA ASSSMTKGET LYDTLLTMQA VGVNVAVIRH SEENYYAGLE KLDIAIVNGG 130 140 150 160 170 180 DGCGEHPSQS LLDLFTIKEQ FGTFQGLKVA IAGDIRHSRV ANSNMKVLKR LGAELFFSGP 190 200 210 220 230 240 REWFDESYLA YGTYLSVDEI VEKVDVLMLL RVQHERHSGT DEFTKESYHE KFGLTENRAK 250 260 270 280 290 300 QLKEDAIIMH PSPVNRDVEI ADSLVESEKS RIVTQMTNGV FIRMAILEAI LKEQEMRAKL CTY

References

[1]

"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species." Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M. Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: F2365.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017262 Genomic DNA. Translation: AAT04636.1.
RefSeq	YP_014459.1. NC_002973.6.
3D structure databases
ProteinModelPortal	Q71YH8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q71YH8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2797280.
GenomeReviews	Gene locus LMOf2365_1866 in contig AE017262_GR.
KEGG	lmf:LMOf2365_1866.
PATRIC	20325025. VBILisMon105049_1872.
TIGR	LMOf2365_1866.
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	VGIPIIN.
PhylomeDB	Q71YH8.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	LMON265669:LMOF2365_1866-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_LISMF

Accession

Primary (citable) accession number: Q71YH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program