Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q71Y02

- DAPF_LISMF

UniProt

Q71Y02 - DAPF_LISMF

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141SubstrateUniRule annotation
    Binding sitei53 – 531SubstrateUniRule annotation
    Binding sitei73 – 731SubstrateUniRule annotation
    Active sitei82 – 821Proton donor/acceptorUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Sitei172 – 1721Important for catalytic activityUniRule annotation
    Binding sitei206 – 2061SubstrateUniRule annotation
    Sitei224 – 2241Important for catalytic activityUniRule annotation
    Active sitei233 – 2331Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:LMOf2365_2043
    OrganismiListeria monocytogenes serotype 4b (strain F2365)
    Taxonomic identifieri265669 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000563: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Diaminopimelate epimerasePRO_0000149850Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi82 ↔ 233

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi265669.LMOf2365_2043.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71Y02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 843Substrate bindingUniRule annotation
    Regioni224 – 2252Substrate bindingUniRule annotation
    Regioni234 – 2352Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiKDITVMV.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q71Y02-1 [UniParc]FASTAAdd to Basket

    « Hide

    METIHFTKVH GSQNDFFLVD EEENHITEWS DEKRANFAIK LCDRKHSLGG    50
    ADGILYVTKS SEVGPIGQMR VVNSDGSIAS MCGNGLRTVA RYLLEKHALT 100
    DAKVETMKAI LDVKKATSLG FDIPTYQVEI SPVKFAAETL PMHVGVEKLF 150
    NQVIPELDAE LAFSAVSVPN PHLITFVDQA VLDSNKQEKL ASYLNSENPY 200
    FPDGVNVSFV KRLSDDAIYV RTFERGVGFT NACGTAMSAC SLIKKMLDNN 250
    ILETPLNVYN DGGRVQVTAK KDAAGEISLQ LIGNATFVSK GSVRYENDIV 300
    TELTNEATAE QAQYQALVKE VKEFLKTTE 329
    Length:329
    Mass (Da):36,210
    Last modified:July 5, 2004 - v1
    Checksum:i3990545E54956E5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017262 Genomic DNA. Translation: AAT04813.1.
    RefSeqiYP_014636.1. NC_002973.6.

    Genome annotation databases

    EnsemblBacteriaiAAT04813; AAT04813; LMOf2365_2043.
    GeneIDi2797774.
    KEGGilmf:LMOf2365_2043.
    PATRICi20325381. VBILisMon105049_2050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017262 Genomic DNA. Translation: AAT04813.1 .
    RefSeqi YP_014636.1. NC_002973.6.

    3D structure databases

    ProteinModelPortali Q71Y02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 265669.LMOf2365_2043.

    Protocols and materials databases

    DNASUi 2797774.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT04813 ; AAT04813 ; LMOf2365_2043 .
    GeneIDi 2797774.
    KEGGi lmf:LMOf2365_2043.
    PATRICi 20325381. VBILisMon105049_2050.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi KDITVMV.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: F2365.

    Entry informationi

    Entry nameiDAPF_LISMF
    AccessioniPrimary (citable) accession number: Q71Y02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3