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Q71Y02

- DAPF_LISMF

UniProt

Q71Y02 - DAPF_LISMF

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Listeria monocytogenes serotype 4b (strain F2365)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141SubstrateUniRule annotation
Binding sitei53 – 531SubstrateUniRule annotation
Binding sitei73 – 731SubstrateUniRule annotation
Active sitei82 – 821Proton donor/acceptorUniRule annotation
Binding sitei170 – 1701SubstrateUniRule annotation
Sitei172 – 1721Important for catalytic activityUniRule annotation
Binding sitei206 – 2061SubstrateUniRule annotation
Sitei224 – 2241Important for catalytic activityUniRule annotation
Active sitei233 – 2331Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:LMOf2365_2043
OrganismiListeria monocytogenes serotype 4b (strain F2365)
Taxonomic identifieri265669 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000563: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Diaminopimelate epimerasePRO_0000149850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 233

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi265669.LMOf2365_2043.

Structurei

3D structure databases

ProteinModelPortaliQ71Y02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Substrate bindingUniRule annotation
Regioni224 – 2252Substrate bindingUniRule annotation
Regioni234 – 2352Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKDITVMV.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71Y02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METIHFTKVH GSQNDFFLVD EEENHITEWS DEKRANFAIK LCDRKHSLGG
60 70 80 90 100
ADGILYVTKS SEVGPIGQMR VVNSDGSIAS MCGNGLRTVA RYLLEKHALT
110 120 130 140 150
DAKVETMKAI LDVKKATSLG FDIPTYQVEI SPVKFAAETL PMHVGVEKLF
160 170 180 190 200
NQVIPELDAE LAFSAVSVPN PHLITFVDQA VLDSNKQEKL ASYLNSENPY
210 220 230 240 250
FPDGVNVSFV KRLSDDAIYV RTFERGVGFT NACGTAMSAC SLIKKMLDNN
260 270 280 290 300
ILETPLNVYN DGGRVQVTAK KDAAGEISLQ LIGNATFVSK GSVRYENDIV
310 320
TELTNEATAE QAQYQALVKE VKEFLKTTE
Length:329
Mass (Da):36,210
Last modified:July 5, 2004 - v1
Checksum:i3990545E54956E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT04813.1.
RefSeqiYP_014636.1. NC_002973.6.

Genome annotation databases

EnsemblBacteriaiAAT04813; AAT04813; LMOf2365_2043.
GeneIDi2797774.
KEGGilmf:LMOf2365_2043.
PATRICi20325381. VBILisMon105049_2050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017262 Genomic DNA. Translation: AAT04813.1 .
RefSeqi YP_014636.1. NC_002973.6.

3D structure databases

ProteinModelPortali Q71Y02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 265669.LMOf2365_2043.

Protocols and materials databases

DNASUi 2797774.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT04813 ; AAT04813 ; LMOf2365_2043 .
GeneIDi 2797774.
KEGGi lmf:LMOf2365_2043.
PATRICi 20325381. VBILisMon105049_2050.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KDITVMV.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F2365.

Entry informationi

Entry nameiDAPF_LISMF
AccessioniPrimary (citable) accession number: Q71Y02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3