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Q71XF4 (HEMH_LISMF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:LMOf2365_2244
OrganismListeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]
Taxonomic identifier265669 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Ferrochelatase HAMAP MF_00323
PRO_0000175160

Sites

Metal binding1821Iron By similarity
Metal binding2631Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q71XF4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1AE5CC6331A45B85

FASTA30935,405
        10         20         30         40         50         60 
MTKKVGLLVM AYGTPYKDED IERYYTDIRH GHKPSEEMIA DLRGRYHAIG GLSPLAKITE 

        70         80         90        100        110        120 
AQAYGLEKAL NESQDEVEFK AYIGLKHIEP FIEDAVEAMH KDGIEEAISI VLAPHYSSFS 

       130        140        150        160        170        180 
VEAYNKRAKD AADKLGGLRI KAINDWYKQP KFIQMWADRI NETAKQIPAD ELLDTVLIVS 

       190        200        210        220        230        240 
AHSLPEKIKQ HNDPYPDQLQ ETADFIFEKV VVPHYALGWQ SEGKTGEPWL GPDVQDLTRE 

       250        260        270        280        290        300 
LYGREKYKHF IYTPVGFVAE HLEVLYDNDY ECKVVTDEVG ATYHRPPMPN SDPEFLEVLR 


TVVWEKYSN

« Hide

References

[1]"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species."
Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. expand/collapse author list , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M.
Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: F2365.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017262 Genomic DNA. Translation: AAT05011.1.
RefSeqYP_014834.1. NC_002973.6.

3D structure databases

ProteinModelPortalQ71XF4.
SMRQ71XF4. Positions 3-306.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ71XF4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2799564.
GenomeReviewsGene locus LMOf2365_2244 in contig AE017262_GR.
KEGGlmf:LMOf2365_2244.
PATRIC20325811. VBILisMon105049_2259.
TIGRLMOf2365_2244.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMASWYDEPK.
PhylomeDBQ71XF4.
ProtClustDBPRK12435.

Enzyme and pathway databases

BioCycLMON265669:LMOF2365_2244-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LISMF
AccessionPrimary (citable) accession number: Q71XF4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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