Reviewed, UniProtKB/Swiss-Prot Q71WW9 (TPIS1_LISMF)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase 1
      Short name=TIM 1
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase 1

Gene names

Name:	tpiA1
Ordered Locus Names:	LMOf2365_2430

Organism

Listeria monocytogenes serotype 4b (strain F2365) [Complete proteome] [HAMAP]

Taxonomic identifier

265669 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147
Subunit structure	Homodimer By similarity. HAMAP MF_00147
Subcellular location	Cytoplasm Probable HAMAP MF_00147.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Triosephosphate isomerase 1 HAMAP MF_00147		PRO_0000090240
Sites
	Active site	95	1	Electrophile By similarity
	Active site	167	1	Proton acceptor By similarity
	Binding site	9	1	Substrate By similarity
	Binding site	11	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q71WW9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6E9D1F2A0DEAF0DF	FASTA	251	26,861
	10 20 30 40 50 60 MRKPIIAGNW KMNKTAAKAG QFAEDVKNNV PSSDAVESVV AAPALFLQEL VRLTEGTNLR 70 80 90 100 110 120 VAAQNCYFED EGAFTGEISP FALADLGVSY VIIGHSERRE YFHETDEDIN KKAHAIFKHG 130 140 150 160 170 180 MTPIICCGET LDQREAGQTD TWVRGQIRAA LAGLTEEQVI KSVIAYEPIW AIGTGKSSTS 190 200 210 220 230 240 ADANETCAVI RAEVADAVSQ KAADAVRIQY GGSVKPENIA DYLAESDIDG ALVGGASLEP 250 ASFLALLEAV K

References

[1]

"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species." Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J. , Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M. Nucleic Acids Res. 32:2386-2395(2004) [PubMed: 15115801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017262 Genomic DNA. Translation: AAT05196.1.
RefSeq	YP_015019.1.
3D structure databases
SMR	Q71WW9. Positions 2-249.
ModBase	Search...
Protein-protein interaction databases
STRING	Q71WW9.
Genome annotation databases
GeneID	2799556.
GenomeReviews	Gene locus LMOf2365_2430 in contig AE017262_GR.
KEGG	lmf:LMOf2365_2430.
TIGR	LMOf2365_2430.
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HBG708281.
OMA	DIRSVQT.
Enzyme and pathway databases
BioCyc	LMON265669:LMOF2365_2430-MONOMER.
Family and domain databases
HAMAP	MF_00147_B. TIM_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS1_LISMF

Accession

Primary (citable) accession number: Q71WW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)