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Q71VM4

- IMA1A_ORYSJ

UniProt

Q71VM4 - IMA1A_ORYSJ

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Protein
Importin subunit alpha-1a
Gene
Os01g0253300, LOC_Os01g14950
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.2 Publications

GO - Molecular functioni

  1. protein transporter activity Source: InterPro

GO - Biological processi

  1. defense response Source: EnsemblPlants/Gramene
  2. pollen sperm cell differentiation Source: EnsemblPlants/Gramene
  3. protein import into nucleus Source: InterPro
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-1a
Gene namesi
Ordered Locus Names:Os01g0253300, LOC_Os01g14950
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ71VM4.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication

GO - Cellular componenti

  1. cell wall Source: EnsemblPlants/Gramene
  2. cytosol Source: EnsemblPlants/Gramene
  3. nuclear envelope Source: EnsemblPlants/Gramene
  4. nucleolus Source: EnsemblPlants/Gramene
  5. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  6. plasmodesma Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Importin subunit alpha-1a
PRO_0000120740Add
BLAST

Proteomic databases

PRIDEiQ71VM4.

Expressioni

Tissue specificityi

Highly expressed in callus, followed by root and etiolated leaf. Low expression in green leaf.2 Publications

Inductioni

In both etiolated and green leaves, down-regulated by light. In green leaf, increased by dark treatment.2 Publications

Interactioni

Subunit structurei

Forms a complex with importin subunit beta-1. The whole complex, most stable and composed of importin alpha, importin beta and NLS substrate, is referred to as PTAC or pore targeting complex. Interacts with mungbean yellow mosaic virus capsid protein.2 Publications

Protein-protein interaction databases

IntActiQ71VM4. 2 interactions.
MINTiMINT-6948326.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi74 – 829
Helixi86 – 10015
Beta strandi103 – 1053
Helixi108 – 1136
Helixi117 – 1237
Helixi130 – 14415
Helixi148 – 1569
Helixi159 – 1668
Helixi172 – 18615
Helixi190 – 1989
Helixi202 – 2076
Helixi215 – 22915
Beta strandi231 – 2333
Helixi237 – 2404
Helixi243 – 2508
Helixi256 – 26914
Beta strandi271 – 2733
Helixi274 – 2829
Helixi286 – 2927
Helixi298 – 31114
Helixi316 – 3238
Turni324 – 3263
Helixi327 – 33610
Helixi341 – 35515
Helixi359 – 36810
Helixi371 – 38010
Helixi383 – 39917
Helixi402 – 4109
Helixi414 – 4196
Helixi420 – 4223
Helixi426 – 44924
Helixi456 – 4638
Helixi466 – 4738
Helixi479 – 49214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNSX-ray2.10A/B73-526[»]
4B8JX-ray2.00A1-526[»]
4B8OX-ray2.08A73-526[»]
4B8PX-ray2.30A/B73-526[»]
4BPLX-ray2.30A73-526[»]
4BQKX-ray2.00A/B73-526[»]
ProteinModelPortaliQ71VM4.
SMRiQ71VM4. Positions 77-496.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858IBB
Add
BLAST
Repeati105 – 14541ARM 1
Add
BLAST
Repeati148 – 18740ARM 2
Add
BLAST
Repeati190 – 23041ARM 3
Add
BLAST
Repeati232 – 27140ARM 4
Add
BLAST
Repeati274 – 31340ARM 5
Add
BLAST
Repeati316 – 35641ARM 6
Add
BLAST
Repeati359 – 39840ARM 7
Add
BLAST
Repeati402 – 44140ARM 8
Add
BLAST

Sequence similaritiesi

Belongs to the importin alpha family.
Contains 8 ARM repeats.
Contains 1 IBB domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5064.
HOGENOMiHOG000167616.
OMAiMEKIFEC.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71VM4-1 [UniParc]FASTAAdd to Basket

« Hide

MSLRPSERVE VRRNRYKVAV DAEEGRRRRE DNMVEIRKSR REESLLKKRR    50
EGLQAQAPVP ASAATGVDKK LESLPAMIGG VYSDDNNLQL EATTQFRKLL 100
SIERSPPIEE VIQSGVVPRF VQFLTREDFP QLQFEAAWAL TNIASGTSEN 150
TKVVIDHGAV PIFVKLLGSS SDDVREQAVW ALGNVAGDSP KCRDLVLANG 200
ALLPLLAQLN EHTKLSMLRN ATWTLSNFCR GKPQPSFEQT RPALPALARL 250
IHSNDEEVLT DACWALSYLS DGTNDKIQAV IEAGVCPRLV ELLLHPSPSV 300
LIPALRTVGN IVTGDDAQTQ CIIDHQALPC LLSLLTQNLK KSIKKEACWT 350
ISNITAGNKD QIQAVINAGI IGPLVNLLQT AEFDIKKEAA WAISNATSGG 400
SHDQIKYLVS EGCIKPLCDL LICPDIRIVT VCLEGLENIL KVGETDKTLA 450
AGDVNVFSQM IDEAEGLEKI ENLQSHDNNE IYEKAVKILE AYWMDEEDDT 500
MGATTVAAPQ GATFDFGQGG GAAQFK 526
Length:526
Mass (Da):57,571
Last modified:April 26, 2005 - v2
Checksum:i7A7DA264968FC983
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4742LQ → FE in AAQ13406. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004660 mRNA. Translation: BAA31165.1.
AF005265 mRNA. Translation: AAQ13406.1.
AB004814 Genomic DNA. Translation: BAA31166.1.
AP000816 Genomic DNA. Translation: BAA87855.1.
RefSeqiNP_001042611.1. NM_001049146.1.
UniGeneiOs.3405.

Genome annotation databases

EnsemblPlantsiOS01T0253300-01; OS01T0253300-01; OS01G0253300.
OS01T0253300-02; OS01T0253300-02; OS01G0253300.
GeneIDi4327117.
KEGGiosa:4327117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004660 mRNA. Translation: BAA31165.1 .
AF005265 mRNA. Translation: AAQ13406.1 .
AB004814 Genomic DNA. Translation: BAA31166.1 .
AP000816 Genomic DNA. Translation: BAA87855.1 .
RefSeqi NP_001042611.1. NM_001049146.1.
UniGenei Os.3405.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YNS X-ray 2.10 A/B 73-526 [» ]
4B8J X-ray 2.00 A 1-526 [» ]
4B8O X-ray 2.08 A 73-526 [» ]
4B8P X-ray 2.30 A/B 73-526 [» ]
4BPL X-ray 2.30 A 73-526 [» ]
4BQK X-ray 2.00 A/B 73-526 [» ]
ProteinModelPortali Q71VM4.
SMRi Q71VM4. Positions 77-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q71VM4. 2 interactions.
MINTi MINT-6948326.

Proteomic databases

PRIDEi Q71VM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0253300-01 ; OS01T0253300-01 ; OS01G0253300 .
OS01T0253300-02 ; OS01T0253300-02 ; OS01G0253300 .
GeneIDi 4327117.
KEGGi osa:4327117.

Organism-specific databases

Gramenei Q71VM4.

Phylogenomic databases

eggNOGi COG5064.
HOGENOMi HOG000167616.
OMAi MEKIFEC.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view ]
Pfami PF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view ]
PIRSFi PIRSF005673. Importin_alpha. 1 hit.
SMARTi SM00185. ARM. 8 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a cDNA encoding an importin-alpha and down-regulation of the gene by light in rice leaves."
    Shoji K., Iwasaki T., Matsuki R., Miyao M., Yamamoto N.
    Gene 212:279-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Nipponbare.
    Tissue: Callus and Leaf.
  2. "Importin alpha-3, a novel variant of the small importin subunit evolutionarily conserved from hydrozoa to man."
    Fischer R.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Functional characterization of a plant importin alpha homologue. Nuclear localization signal (NLS)-selective binding and mediation of nuclear import of nls proteins in vitro."
    Jiang C.-J., Imamoto N., Matsuki R., Yoneda Y., Yamamoto N.
    J. Biol. Chem. 273:24083-24087(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Molecular cloning of a novel importin alpha homologue from rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported."
    Jiang C.-J., Shoji K., Matsuki R., Baba A., Inagaki N., Ban H., Iwasaki T., Imamoto N., Yoneda Y., Deng X.-W., Yamamoto N.
    J. Biol. Chem. 276:9322-9329(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH IMPORTIN BETA-1.
  6. "Coat proteins of Rice tungro bacilliform virus and Mungbean yellow mosaic virus contain multiple nuclear-localization signals and interact with importin alpha."
    Guerra-Peraza O., Kirk D., Seltzer V., Veluthambi K., Schmit A.C., Hohn T., Herzog E.
    J. Gen. Virol. 86:1815-1826(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUNGBEAN YELLOW MOSAIC VIRUS CAPSID PROTEIN.

Entry informationi

Entry nameiIMA1A_ORYSJ
AccessioniPrimary (citable) accession number: Q71VM4
Secondary accession number(s): O82783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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