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Protein

Importin subunit alpha-1a

Gene

Os01g0253300

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-1a
Gene namesi
Ordered Locus Names:Os01g0253300, LOC_Os01g14950
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207401 – 526Importin subunit alpha-1aAdd BLAST526

Proteomic databases

PaxDbiQ71VM4.
PRIDEiQ71VM4.

Expressioni

Tissue specificityi

Highly expressed in callus, followed by root and etiolated leaf. Low expression in green leaf.2 Publications

Inductioni

In both etiolated and green leaves, down-regulated by light. In green leaf, increased by dark treatment.2 Publications

Gene expression databases

ExpressionAtlasiQ71VM4. baseline and differential.
GenevisibleiQ71VM4. OS.

Interactioni

Subunit structurei

Forms a complex with importin subunit beta-1. The whole complex, most stable and composed of importin alpha, importin beta and NLS substrate, is referred to as PTAC or pore targeting complex. Interacts with mungbean yellow mosaic virus capsid protein.2 Publications

Protein-protein interaction databases

IntActiQ71VM4. 2 interactors.
MINTiMINT-6948326.
STRINGi39947.LOC_Os01g14950.1.

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi74 – 82Combined sources9
Helixi86 – 100Combined sources15
Beta strandi103 – 105Combined sources3
Helixi108 – 113Combined sources6
Helixi117 – 123Combined sources7
Helixi130 – 144Combined sources15
Helixi148 – 156Combined sources9
Helixi159 – 166Combined sources8
Helixi172 – 186Combined sources15
Helixi190 – 198Combined sources9
Helixi202 – 207Combined sources6
Helixi215 – 229Combined sources15
Beta strandi231 – 233Combined sources3
Helixi237 – 240Combined sources4
Helixi243 – 250Combined sources8
Helixi256 – 269Combined sources14
Beta strandi271 – 273Combined sources3
Helixi274 – 282Combined sources9
Helixi286 – 292Combined sources7
Helixi298 – 311Combined sources14
Helixi316 – 323Combined sources8
Turni324 – 326Combined sources3
Helixi327 – 336Combined sources10
Helixi341 – 355Combined sources15
Helixi359 – 368Combined sources10
Helixi371 – 380Combined sources10
Helixi383 – 399Combined sources17
Helixi402 – 410Combined sources9
Helixi414 – 419Combined sources6
Helixi420 – 422Combined sources3
Helixi426 – 449Combined sources24
Helixi456 – 463Combined sources8
Helixi466 – 473Combined sources8
Helixi479 – 492Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YNSX-ray2.10A/B73-526[»]
4B8JX-ray2.00A1-526[»]
4B8OX-ray2.08A73-526[»]
4B8PX-ray2.30A/B73-526[»]
4BPLX-ray2.30A73-526[»]
4BQKX-ray2.00A/B73-526[»]
ProteinModelPortaliQ71VM4.
SMRiQ71VM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58IBBPROSITE-ProRule annotationAdd BLAST58
Repeati105 – 145ARM 1Add BLAST41
Repeati148 – 187ARM 2Add BLAST40
Repeati190 – 230ARM 3Add BLAST41
Repeati232 – 271ARM 4Add BLAST40
Repeati274 – 313ARM 5Add BLAST40
Repeati316 – 356ARM 6Add BLAST41
Repeati359 – 398ARM 7Add BLAST40
Repeati402 – 441ARM 8Add BLAST40

Sequence similaritiesi

Belongs to the importin alpha family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation
Contains 1 IBB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOGENOMiHOG000167616.
InParanoidiQ71VM4.
OMAiGTNQQQP.
OrthoDBiEOG09360724.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71VM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRPSERVE VRRNRYKVAV DAEEGRRRRE DNMVEIRKSR REESLLKKRR
60 70 80 90 100
EGLQAQAPVP ASAATGVDKK LESLPAMIGG VYSDDNNLQL EATTQFRKLL
110 120 130 140 150
SIERSPPIEE VIQSGVVPRF VQFLTREDFP QLQFEAAWAL TNIASGTSEN
160 170 180 190 200
TKVVIDHGAV PIFVKLLGSS SDDVREQAVW ALGNVAGDSP KCRDLVLANG
210 220 230 240 250
ALLPLLAQLN EHTKLSMLRN ATWTLSNFCR GKPQPSFEQT RPALPALARL
260 270 280 290 300
IHSNDEEVLT DACWALSYLS DGTNDKIQAV IEAGVCPRLV ELLLHPSPSV
310 320 330 340 350
LIPALRTVGN IVTGDDAQTQ CIIDHQALPC LLSLLTQNLK KSIKKEACWT
360 370 380 390 400
ISNITAGNKD QIQAVINAGI IGPLVNLLQT AEFDIKKEAA WAISNATSGG
410 420 430 440 450
SHDQIKYLVS EGCIKPLCDL LICPDIRIVT VCLEGLENIL KVGETDKTLA
460 470 480 490 500
AGDVNVFSQM IDEAEGLEKI ENLQSHDNNE IYEKAVKILE AYWMDEEDDT
510 520
MGATTVAAPQ GATFDFGQGG GAAQFK
Length:526
Mass (Da):57,571
Last modified:April 26, 2005 - v2
Checksum:i7A7DA264968FC983
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti473 – 474LQ → FE in AAQ13406 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004660 mRNA. Translation: BAA31165.1.
AF005265 mRNA. Translation: AAQ13406.1.
AB004814 Genomic DNA. Translation: BAA31166.1.
AP000816 Genomic DNA. Translation: BAA87855.1.
AP014957 Genomic DNA. Translation: BAS71366.1.
RefSeqiXP_015621115.1. XM_015765629.1.
UniGeneiOs.3405.

Genome annotation databases

EnsemblPlantsiOS01T0253300-01; OS01T0253300-01; OS01G0253300.
OS01T0253300-02; OS01T0253300-02; OS01G0253300.
GeneIDi4327117.
GrameneiOS01T0253300-01; OS01T0253300-01; OS01G0253300.
OS01T0253300-02; OS01T0253300-02; OS01G0253300.
KEGGiosa:4327117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004660 mRNA. Translation: BAA31165.1.
AF005265 mRNA. Translation: AAQ13406.1.
AB004814 Genomic DNA. Translation: BAA31166.1.
AP000816 Genomic DNA. Translation: BAA87855.1.
AP014957 Genomic DNA. Translation: BAS71366.1.
RefSeqiXP_015621115.1. XM_015765629.1.
UniGeneiOs.3405.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YNSX-ray2.10A/B73-526[»]
4B8JX-ray2.00A1-526[»]
4B8OX-ray2.08A73-526[»]
4B8PX-ray2.30A/B73-526[»]
4BPLX-ray2.30A73-526[»]
4BQKX-ray2.00A/B73-526[»]
ProteinModelPortaliQ71VM4.
SMRiQ71VM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ71VM4. 2 interactors.
MINTiMINT-6948326.
STRINGi39947.LOC_Os01g14950.1.

Proteomic databases

PaxDbiQ71VM4.
PRIDEiQ71VM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS01T0253300-01; OS01T0253300-01; OS01G0253300.
OS01T0253300-02; OS01T0253300-02; OS01G0253300.
GeneIDi4327117.
GrameneiOS01T0253300-01; OS01T0253300-01; OS01G0253300.
OS01T0253300-02; OS01T0253300-02; OS01G0253300.
KEGGiosa:4327117.

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
HOGENOMiHOG000167616.
InParanoidiQ71VM4.
OMAiGTNQQQP.
OrthoDBiEOG09360724.

Gene expression databases

ExpressionAtlasiQ71VM4. baseline and differential.
GenevisibleiQ71VM4. OS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMA1A_ORYSJ
AccessioniPrimary (citable) accession number: Q71VM4
Secondary accession number(s): O82783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.