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Protein
Submitted name:

Interleukin 10

Gene

IL10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • immune response Source: InterPro
  • negative regulation of chemokine (C-C motif) ligand 5 production Source: AgBase
  • negative regulation of interleukin-12 production Source: AgBase
  • negative regulation of interleukin-18 production Source: AgBase
  • negative regulation of interleukin-1 production Source: AgBase
  • negative regulation of interleukin-6 production Source: AgBase
  • negative regulation of interleukin-8 production Source: AgBase
  • negative regulation of tumor necrosis factor production Source: AgBase

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 10Imported
Gene namesi
Name:IL10Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ71UZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 134Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
HOVERGENiHBG004110.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
PfamiView protein in Pfam
PF00726. IL10. 1 hit.
PRINTSiPR01294. INTRLEUKIN10.
SMARTiView protein in SMART
SM00188. IL10. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00520. INTERLEUKIN_10. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q71UZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE
60 70 80 90 100
SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT
110 120 130 140 150
LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI
160
EAYMTMKIRN
Length:160
Mass (Da):18,647
Last modified:July 5, 2004 - v1
Checksum:i7ACF95AF4302E5A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043333 mRNA. Translation: AAC03534.1.
UniGeneiHs.193717.

Similar proteinsi

Entry informationi

Entry nameiQ71UZ1_HUMAN
AccessioniPrimary (citable) accession number: Q71UZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 31, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.