ID   RS27L_HUMAN             Reviewed;          84 AA.
AC   Q71UM5; Q9BTJ1;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   09-JAN-2013, entry version 81.
DE   RecName: Full=40S ribosomal protein S27-like;
GN   Name=RPS27L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Umbilical cord blood;
RX   MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for
RT   300 previously undefined genes expressed in CD34+ hematopoietic
RT   stem/progenitor cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (Potential).
CC   -!- INTERACTION:
CC       Q00987:MDM2; NbExp=6; IntAct=EBI-355126, EBI-389668;
CC   -!- SIMILARITY: Belongs to the ribosomal protein S27e family.
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DR   EMBL; AF070668; AAD20974.1; -; mRNA.
DR   EMBL; BC003667; AAH03667.1; -; mRNA.
DR   IPI; IPI00746004; -.
DR   RefSeq; NP_057004.1; NM_015920.3.
DR   UniGene; Hs.108957; -.
DR   ProteinModelPortal; Q71UM5; -.
DR   SMR; Q71UM5; 3-82.
DR   IntAct; Q71UM5; 9.
DR   MINT; MINT-1158751; -.
DR   STRING; Q71UM5; -.
DR   PhosphoSite; Q71UM5; -.
DR   DMDM; 51316258; -.
DR   PaxDb; Q71UM5; -.
DR   PRIDE; Q71UM5; -.
DR   DNASU; 51065; -.
DR   Ensembl; ENST00000330964; ENSP00000331019; ENSG00000185088.
DR   GeneID; 51065; -.
DR   KEGG; hsa:51065; -.
DR   UCSC; uc002aly.3; human.
DR   CTD; 51065; -.
DR   GeneCards; GC15M063445; -.
DR   HGNC; HGNC:18476; RPS27L.
DR   MIM; 612055; gene.
DR   neXtProt; NX_Q71UM5; -.
DR   PharmGKB; PA38546; -.
DR   eggNOG; COG2051; -.
DR   HOVERGEN; HBG000252; -.
DR   KO; K02978; -.
DR   OMA; AQTVVVC; -.
DR   OrthoDB; EOG4H19XB; -.
DR   GenomeRNAi; 51065; -.
DR   NextBio; 53659; -.
DR   ArrayExpress; Q71UM5; -.
DR   Bgee; Q71UM5; -.
DR   CleanEx; HS_RPS27L; -.
DR   Genevestigator; Q71UM5; -.
DR   GermOnline; ENSG00000185088; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IDA:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IDA:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IMP:UniProtKB.
DR   GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:UniProtKB.
DR   GO; GO:0031571; P:mitotic cell cycle G1/S transition DNA damage checkpoint; IMP:UniProtKB.
DR   GO; GO:0006412; P:translation; IDA:UniProtKB.
DR   Gene3D; 2.20.25.100; G3DSA:2.20.25.100; 1.
DR   InterPro; IPR000592; Ribosomal_S27e.
DR   InterPro; IPR023407; Ribosomal_S27e_Zn-bd_dom.
DR   InterPro; IPR011332; Ribosomal_zn-bd_dom.
DR   PANTHER; PTHR11594; PTHR11594; 1.
DR   Pfam; PF01667; Ribosomal_S27e; 1.
DR   ProDom; PD004466; Ribosomal_S27e; 1.
DR   SUPFAM; SSF57829; Ribosomal_zn-bd; 1.
DR   PROSITE; PS01168; RIBOSOMAL_S27E; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Metal-binding; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; Zinc; Zinc-finger.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2     84       40S ribosomal protein S27-like.
FT                                /FTId=PRO_0000149054.
FT   ZN_FING      38     60       C4-type.
FT   MOD_RES      27     27       Phosphoserine.
FT   CONFLICT     22     22       K -> E (in Ref. 2).
SQ   SEQUENCE   84 AA;  9477 MW;  271CCACFBB269E38 CRC64;
     MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS
     TVLCQPTGGK ARLTEGCSFR RKQH
//