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Q71UM5 (RS27L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S27-like
Gene names
Name:RPS27L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length84 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 1 zinc ion per subunit Potential.

Sequence similarities

Belongs to the ribosomal protein S27e family.

Ontologies

Keywords
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from mutant phenotype PubMed 18056458. Source: UniProtKB

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from direct assay PubMed 17057733. Source: GOC

cellular response to DNA damage stimulus

Inferred from direct assay PubMed 18056458. Source: UniProtKB

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from direct assay PubMed 17057733. Source: UniProtKB

mitotic G1 DNA damage checkpoint

Inferred from mutant phenotype PubMed 18056458. Source: UniProtKB

positive regulation of translation

Inferred from direct assay PubMed 18056458. Source: GOC

translation

Inferred from direct assay PubMed 18056458. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay PubMed 18056458. Source: UniProtKB

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process

Inferred from direct assay PubMed 17057733. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 21170087. Source: IntAct

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

translation activator activity

Inferred from direct assay PubMed 18056458. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDM2Q009876EBI-355126,EBI-389668

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 848340S ribosomal protein S27-like HAMAP-Rule MF_00371
PRO_0000149054

Regions

Zinc finger38 – 6023C4-type Potential

Experimental info

Sequence conflict221K → E Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q71UM5 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 271CCACFBB269E38

FASTA849,477
        10         20         30         40         50         60 
MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS 

        70         80 
TVLCQPTGGK ARLTEGCSFR RKQH 

« Hide

References

[1]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF070668 mRNA. Translation: AAD20974.1.
BC003667 mRNA. Translation: AAH03667.1.
CCDSCCDS42048.1.
RefSeqNP_057004.1. NM_015920.3.
UniGeneHs.108957.

3D structure databases

ProteinModelPortalQ71UM5.
SMRQ71UM5. Positions 1-84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119256. 79 interactions.
IntActQ71UM5. 13 interactions.
MINTMINT-1158751.
STRING9606.ENSP00000331019.

PTM databases

PhosphoSiteQ71UM5.

Polymorphism databases

DMDM51316258.

Proteomic databases

MaxQBQ71UM5.
PaxDbQ71UM5.
PRIDEQ71UM5.

Protocols and materials databases

DNASU51065.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330964; ENSP00000331019; ENSG00000185088.
GeneID51065.
KEGGhsa:51065.
UCSCuc002aly.3. human.

Organism-specific databases

CTD51065.
GeneCardsGC15M063445.
HGNCHGNC:18476. RPS27L.
MIM612055. gene.
neXtProtNX_Q71UM5.
PharmGKBPA38546.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2051.
HOVERGENHBG000252.
KOK02978.
OrthoDBEOG78SQM9.
PhylomeDBQ71UM5.
TreeFamTF300265.

Gene expression databases

ArrayExpressQ71UM5.
BgeeQ71UM5.
CleanExHS_RPS27L.
GenevestigatorQ71UM5.

Family and domain databases

Gene3D2.20.25.100. 1 hit.
HAMAPMF_00371. Ribosomal_S27e.
InterProIPR000592. Ribosomal_S27e.
IPR023407. Ribosomal_S27e_Zn-bd_dom.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERPTHR11594. PTHR11594. 1 hit.
PfamPF01667. Ribosomal_S27e. 1 hit.
[Graphical view]
ProDomPD004466. Ribosomal_S27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57829. SSF57829. 1 hit.
PROSITEPS01168. RIBOSOMAL_S27E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPS27L. human.
GenomeRNAi51065.
NextBio53659.
PROQ71UM5.
SOURCESearch...

Entry information

Entry nameRS27L_HUMAN
AccessionPrimary (citable) accession number: Q71UM5
Secondary accession number(s): Q9BTJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM