Q71UM5 (RS27L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S27-like

Gene names

Name:

RPS27L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit Potential.
Sequence similarities	Belongs to the ribosomal protein S27e family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from mutant phenotype PubMed 18056458. Source: UniProtKB intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Inferred from direct assay PubMed 17057733. Source: UniProtKB mitotic G1 DNA damage checkpoint Inferred from mutant phenotype PubMed 18056458. Source: UniProtKB translation Inferred from direct assay PubMed 18056458. Source: UniProtKB
Cellular_component	nucleus Inferred from direct assay PubMed 18056458. Source: UniProtKB ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process Inferred from direct assay PubMed 17057733. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro translation activator activity Inferred from direct assay PubMed 18056458. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDM2	Q00987	6	EBI-355126,EBI-389668

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P24051
	Chain	2 – 84	83	40S ribosomal protein S27-like		PRO_0000149054
Regions
	Zinc finger	38 – 60	23	C4-type Potential
Experimental info
	Sequence conflict	22	1	K → E Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q71UM5 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 271CCACFBB269E38	FASTA	84	9,477
	10 20 30 40 50 60 MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS 70 80 TVLCQPTGGK ARLTEGCSFR RKQH

References

[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF070668 mRNA. Translation: AAD20974.1. BC003667 mRNA. Translation: AAH03667.1.
IPI	IPI00746004.
RefSeq	NP_057004.1. NM_015920.3.
UniGene	Hs.108957.
3D structure databases
ProteinModelPortal	Q71UM5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q71UM5. 9 interactions.
MINT	MINT-1158751.
STRING	9606.ENSP00000331019.
PTM databases
PhosphoSite	Q71UM5.
Polymorphism databases
DMDM	51316258.
Proteomic databases
PaxDb	Q71UM5.
PRIDE	Q71UM5.
Protocols and materials databases
DNASU	51065.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330964; ENSP00000331019; ENSG00000185088.
GeneID	51065.
KEGG	hsa:51065.
UCSC	uc002aly.3. human.
Organism-specific databases
CTD	51065.
GeneCards	GC15M063445.
HGNC	HGNC:18476. RPS27L.
MIM	612055. gene.
neXtProt	NX_Q71UM5.
PharmGKB	PA38546.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2051.
HOVERGEN	HBG000252.
KO	K02978.
OMA	AQTVVVC.
OrthoDB	EOG4H19XB.
Gene expression databases
ArrayExpress	Q71UM5.
Bgee	Q71UM5.
CleanEx	HS_RPS27L.
Genevestigator	Q71UM5.
GermOnline	ENSG00000185088. Homo sapiens.
Family and domain databases
Gene3D	2.20.25.100. 1 hit.
HAMAP	MF_00371. Ribosomal_S27e.
InterPro	IPR000592. Ribosomal_S27e. IPR023407. Ribosomal_S27e_Zn-bd_dom. IPR011332. Ribosomal_zn-bd_dom. [Graphical view]
PANTHER	PTHR11594. PTHR11594. 1 hit.
Pfam	PF01667. Ribosomal_S27e. 1 hit. [Graphical view]
ProDom	PD004466. Ribosomal_S27e. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF57829. Ribosomal_zn-bd. 1 hit.
PROSITE	PS01168. RIBOSOMAL_S27E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS27L. human.
GenomeRNAi	51065.
NextBio	53659.
SOURCE	Search...

Entry information

Entry name

RS27L_HUMAN

Accession

Primary (citable) accession number: Q71UM5
Secondary accession number(s): Q9BTJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.