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Q71UM5

- RS27L_HUMAN

UniProt

Q71UM5 - RS27L_HUMAN

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Protein

40S ribosomal protein S27-like

Gene

RPS27L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
  4. structural constituent of ribosome Source: InterPro
  5. translation activator activity Source: UniProtKB

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. DNA repair Source: UniProtKB
  4. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
  5. mitotic G1 DNA damage checkpoint Source: UniProtKB
  6. positive regulation of translation Source: GOC
  7. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S27-like
Gene namesi
Name:RPS27LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:18476. RPS27L.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 848340S ribosomal protein S27-likePRO_0000149054Add
BLAST

Proteomic databases

MaxQBiQ71UM5.
PaxDbiQ71UM5.
PRIDEiQ71UM5.

PTM databases

PhosphoSiteiQ71UM5.

Expressioni

Gene expression databases

BgeeiQ71UM5.
CleanExiHS_RPS27L.
ExpressionAtlasiQ71UM5. baseline and differential.
GenevestigatoriQ71UM5.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009876EBI-355126,EBI-389668

Protein-protein interaction databases

BioGridi119256. 63 interactions.
IntActiQ71UM5. 13 interactions.
MINTiMINT-1158751.
STRINGi9606.ENSP00000331019.

Structurei

3D structure databases

ProteinModelPortaliQ71UM5.
SMRiQ71UM5. Positions 2-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S27e family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG2051.
GeneTreeiENSGT00390000013514.
HOVERGENiHBG000252.
InParanoidiQ71UM5.
KOiK02978.
OrthoDBiEOG78SQM9.
PhylomeDBiQ71UM5.
TreeFamiTF300265.

Family and domain databases

Gene3Di2.20.25.100. 1 hit.
HAMAPiMF_00371. Ribosomal_S27e.
InterProiIPR000592. Ribosomal_S27e.
IPR023407. Ribosomal_S27e_Zn-bd_dom.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR11594. PTHR11594. 1 hit.
PfamiPF01667. Ribosomal_S27e. 1 hit.
[Graphical view]
ProDomiPD004466. Ribosomal_S27e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01168. RIBOSOMAL_S27E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q71UM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,477
Last modified:January 23, 2007 - v3
Checksum:i271CCACFBB269E38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221K → E(PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070668 mRNA. Translation: AAD20974.1.
BC003667 mRNA. Translation: AAH03667.1.
CCDSiCCDS42048.1.
RefSeqiNP_057004.1. NM_015920.3.
UniGeneiHs.108957.

Genome annotation databases

EnsembliENST00000330964; ENSP00000331019; ENSG00000185088.
GeneIDi51065.
KEGGihsa:51065.
UCSCiuc002aly.3. human.

Polymorphism databases

DMDMi51316258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF070668 mRNA. Translation: AAD20974.1 .
BC003667 mRNA. Translation: AAH03667.1 .
CCDSi CCDS42048.1.
RefSeqi NP_057004.1. NM_015920.3.
UniGenei Hs.108957.

3D structure databases

ProteinModelPortali Q71UM5.
SMRi Q71UM5. Positions 2-84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119256. 63 interactions.
IntActi Q71UM5. 13 interactions.
MINTi MINT-1158751.
STRINGi 9606.ENSP00000331019.

PTM databases

PhosphoSitei Q71UM5.

Polymorphism databases

DMDMi 51316258.

Proteomic databases

MaxQBi Q71UM5.
PaxDbi Q71UM5.
PRIDEi Q71UM5.

Protocols and materials databases

DNASUi 51065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330964 ; ENSP00000331019 ; ENSG00000185088 .
GeneIDi 51065.
KEGGi hsa:51065.
UCSCi uc002aly.3. human.

Organism-specific databases

CTDi 51065.
GeneCardsi GC15M063445.
HGNCi HGNC:18476. RPS27L.
MIMi 612055. gene.
neXtProti NX_Q71UM5.
PharmGKBi PA38546.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2051.
GeneTreei ENSGT00390000013514.
HOVERGENi HBG000252.
InParanoidi Q71UM5.
KOi K02978.
OrthoDBi EOG78SQM9.
PhylomeDBi Q71UM5.
TreeFami TF300265.

Miscellaneous databases

ChiTaRSi RPS27L. human.
GenomeRNAii 51065.
NextBioi 53659.
PROi Q71UM5.
SOURCEi Search...

Gene expression databases

Bgeei Q71UM5.
CleanExi HS_RPS27L.
ExpressionAtlasi Q71UM5. baseline and differential.
Genevestigatori Q71UM5.

Family and domain databases

Gene3Di 2.20.25.100. 1 hit.
HAMAPi MF_00371. Ribosomal_S27e.
InterProi IPR000592. Ribosomal_S27e.
IPR023407. Ribosomal_S27e_Zn-bd_dom.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
PANTHERi PTHR11594. PTHR11594. 1 hit.
Pfami PF01667. Ribosomal_S27e. 1 hit.
[Graphical view ]
ProDomi PD004466. Ribosomal_S27e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57829. SSF57829. 1 hit.
PROSITEi PS01168. RIBOSOMAL_S27E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood1 Publication.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRS27L_HUMAN
AccessioniPrimary (citable) accession number: Q71UM5
Secondary accession number(s): Q9BTJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3