Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q71UM5

- RS27L_HUMAN

UniProt

Q71UM5 - RS27L_HUMAN

Protein

40S ribosomal protein S27-like

Gene

RPS27L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. structural constituent of ribosome Source: InterPro
    6. translation activator activity Source: UniProtKB

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. DNA repair Source: UniProtKB
    4. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
    5. mitotic G1 DNA damage checkpoint Source: UniProtKB
    6. positive regulation of translation Source: GOC
    7. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S27-like
    Gene namesi
    Name:RPS27LImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18476. RPS27L.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. ribosome Source: UniProtKB-KW

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 848340S ribosomal protein S27-likePRO_0000149054Add
    BLAST

    Proteomic databases

    MaxQBiQ71UM5.
    PaxDbiQ71UM5.
    PRIDEiQ71UM5.

    PTM databases

    PhosphoSiteiQ71UM5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ71UM5.
    BgeeiQ71UM5.
    CleanExiHS_RPS27L.
    GenevestigatoriQ71UM5.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDM2Q009876EBI-355126,EBI-389668

    Protein-protein interaction databases

    BioGridi119256. 63 interactions.
    IntActiQ71UM5. 13 interactions.
    MINTiMINT-1158751.
    STRINGi9606.ENSP00000331019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71UM5.
    SMRiQ71UM5. Positions 1-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S27e family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri38 – 6023C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2051.
    HOVERGENiHBG000252.
    KOiK02978.
    OrthoDBiEOG78SQM9.
    PhylomeDBiQ71UM5.
    TreeFamiTF300265.

    Family and domain databases

    Gene3Di2.20.25.100. 1 hit.
    HAMAPiMF_00371. Ribosomal_S27e.
    InterProiIPR000592. Ribosomal_S27e.
    IPR023407. Ribosomal_S27e_Zn-bd_dom.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR11594. PTHR11594. 1 hit.
    PfamiPF01667. Ribosomal_S27e. 1 hit.
    [Graphical view]
    ProDomiPD004466. Ribosomal_S27e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01168. RIBOSOMAL_S27E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q71UM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA   50
    QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH 84
    Length:84
    Mass (Da):9,477
    Last modified:January 23, 2007 - v3
    Checksum:i271CCACFBB269E38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221K → E(PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070668 mRNA. Translation: AAD20974.1.
    BC003667 mRNA. Translation: AAH03667.1.
    CCDSiCCDS42048.1.
    RefSeqiNP_057004.1. NM_015920.3.
    UniGeneiHs.108957.

    Genome annotation databases

    EnsembliENST00000330964; ENSP00000331019; ENSG00000185088.
    GeneIDi51065.
    KEGGihsa:51065.
    UCSCiuc002aly.3. human.

    Polymorphism databases

    DMDMi51316258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070668 mRNA. Translation: AAD20974.1 .
    BC003667 mRNA. Translation: AAH03667.1 .
    CCDSi CCDS42048.1.
    RefSeqi NP_057004.1. NM_015920.3.
    UniGenei Hs.108957.

    3D structure databases

    ProteinModelPortali Q71UM5.
    SMRi Q71UM5. Positions 1-84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119256. 63 interactions.
    IntActi Q71UM5. 13 interactions.
    MINTi MINT-1158751.
    STRINGi 9606.ENSP00000331019.

    PTM databases

    PhosphoSitei Q71UM5.

    Polymorphism databases

    DMDMi 51316258.

    Proteomic databases

    MaxQBi Q71UM5.
    PaxDbi Q71UM5.
    PRIDEi Q71UM5.

    Protocols and materials databases

    DNASUi 51065.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330964 ; ENSP00000331019 ; ENSG00000185088 .
    GeneIDi 51065.
    KEGGi hsa:51065.
    UCSCi uc002aly.3. human.

    Organism-specific databases

    CTDi 51065.
    GeneCardsi GC15M063445.
    HGNCi HGNC:18476. RPS27L.
    MIMi 612055. gene.
    neXtProti NX_Q71UM5.
    PharmGKBi PA38546.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2051.
    HOVERGENi HBG000252.
    KOi K02978.
    OrthoDBi EOG78SQM9.
    PhylomeDBi Q71UM5.
    TreeFami TF300265.

    Miscellaneous databases

    ChiTaRSi RPS27L. human.
    GenomeRNAii 51065.
    NextBioi 53659.
    PROi Q71UM5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q71UM5.
    Bgeei Q71UM5.
    CleanExi HS_RPS27L.
    Genevestigatori Q71UM5.

    Family and domain databases

    Gene3Di 2.20.25.100. 1 hit.
    HAMAPi MF_00371. Ribosomal_S27e.
    InterProi IPR000592. Ribosomal_S27e.
    IPR023407. Ribosomal_S27e_Zn-bd_dom.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR11594. PTHR11594. 1 hit.
    Pfami PF01667. Ribosomal_S27e. 1 hit.
    [Graphical view ]
    ProDomi PD004466. Ribosomal_S27e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01168. RIBOSOMAL_S27E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood1 Publication.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRS27L_HUMAN
    AccessioniPrimary (citable) accession number: Q71UM5
    Secondary accession number(s): Q9BTJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3