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Q71T02

- Q71T02_PLAFA

UniProt

Q71T02 - Q71T02_PLAFA

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Protein
Submitted name:

L-lactate dehydrogenase

Gene

LDH-P

Organism
Plasmodium falciparum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
L-lactate dehydrogenaseImported (EC:1.1.1.27Imported)
Submitted name:
Lactate dehydrogenaseImported (EC:1.1.1.27Imported)
Gene namesi
Name:LDH-PImported
Synonyms:LDHImported, ldhImported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X8LX-ray1.60A1-316[»]
4B7UX-ray1.88A/B/C/D1-316[»]
4PLZX-ray1.05A1-316[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ71T02.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q71T02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH
60 70 80 90 100
TNVMAYSNCK VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP
110 120 130 140 150
LNNKIMIEIG GHIKKNCPNA FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL
160 170 180 190 200
GGVLDTSRLK YYISQKLNVC PRDVNAHIVG AHGNKMVLLK RYITVGGIPL
210 220 230 240 250
QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA AAIIEMAESY
260 270 280 290 300
LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA
310
KFDEAIAETK RMKALA
Length:316
Mass (Da):34,108
Last modified:July 5, 2004 - v1
Checksum:iD25EB863954B8FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251291 Genomic DNA. Translation: AAG14292.1.
DQ198261 Genomic DNA. Translation: ABA46354.1.
DQ198262 Genomic DNA. Translation: ABA46355.1.
EU330208 Genomic DNA. Translation: ABY76169.1.
JN547218 Genomic DNA. Translation: AEP83559.1.
JN547219 Genomic DNA. Translation: AEP83560.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251291 Genomic DNA. Translation: AAG14292.1 .
DQ198261 Genomic DNA. Translation: ABA46354.1 .
DQ198262 Genomic DNA. Translation: ABA46355.1 .
EU330208 Genomic DNA. Translation: ABY76169.1 .
JN547218 Genomic DNA. Translation: AEP83559.1 .
JN547219 Genomic DNA. Translation: AEP83560.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2X8L X-ray 1.60 A 1-316 [» ]
4B7U X-ray 1.88 A/B/C/D 1-316 [» ]
4PLZ X-ray 1.05 A 1-316 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q71T02.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials."
    Turgut-Balik D., Shoemark D.K., Moreton K.M., Sessions R.B., Holbrook J.J.
    Biotechnol. Lett. 23:917-921(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FCBRImported and K1Imported.
  2. "Determination of the DNA and aminoacid sequences of lactate dehydrogenase gene from Plasmodium falciparum strains K1 and PF FCBR: A route to the design of new antimalarials."
    Turgut-Balik D., Holbrook J.J.
    Turk. J. Biol. 25:241-250(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FCBRImported and K1Imported.
  3. "Cloning and sequence analysis of LDH gene of Plasmodium falciparum isolate FCC1/HN."
    Shan Z.X., Yu X.B., Ma C.L., Chen S.Y., Bian G.W.
    Zhongguo Re Dai Yi Xue 1:196-198(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Turgut-Balik D., Moreton K., Holbrook J.J.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FCBRImported and K1Imported.
  5. "Plasmodium falciparum: enhanced soluble expression, purification and biochemical characterization of lactate dehydrogenase."
    Berwal R., Gopalan N., Chandel K., Prasad G.B., Prakash S.
    Exp. Parasitol. 120:135-141(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JindImported.
  6. "The Apo Crystal Structure of Plasmodium Falciparum Lactate Dehydrogenase."
    Birkinshaw R.W., Brady R.L.
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  7. "The Crystal Structure of Plasmodium Falciparum L- Lactate Dehydrogenase in Complex with a Novel Bicine Ligand."
    Birkinshaw R.W., Brady R.L.
    Submitted (AUG-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).
  8. "Plasmodium falciparum and Plasmodium vivax specific lactate dehydrogenase: Genetic polymorphism study from Indian isolates."
    Keluskar P., Singh V., Gupta P., Ingle S.
    Infect. Genet. Evol. 26:313-322(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Mzr-1Imported and Ori-1Imported.
  9. "An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactatedehydrogenases."
    Boucher J.I., Jacobowitz J.R., Beckett B.C., Classen S., Theobald D.L.
    Submitted (MAY-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS).

Entry informationi

Entry nameiQ71T02_PLAFA
AccessioniPrimary (citable) accession number: Q71T02
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3