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Q71T02 (Q71T02_PLAFA) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=1.1.1.27 EMBL ABA46354.1

Lactate dehydrogenase EMBL ABY76169.1
EC=1.1.1.27 EMBL ABY76169.1
Gene names
Name:LDH-P EMBL AAG14292.1
Synonyms:LDH EMBL ABA46354.1, ldh EMBL AEP83559.1
OrganismPlasmodium falciparum EMBL AAG14292.1
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the LDH/MDH superfamily. RuleBase RU003369

Ontologies

Keywords
   Molecular functionOxidoreductase RuleBase RU003369 EMBL ABA46354.1
   Technical term3D-structure PDB 2X8L PDB 4B7U
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q71T02 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D25EB863954B8FC1

FASTA31634,108
        10         20         30         40         50         60 
MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH TNVMAYSNCK 

        70         80         90        100        110        120 
VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP LNNKIMIEIG GHIKKNCPNA 

       130        140        150        160        170        180 
FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL GGVLDTSRLK YYISQKLNVC PRDVNAHIVG 

       190        200        210        220        230        240 
AHGNKMVLLK RYITVGGIPL QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA 

       250        260        270        280        290        300 
AAIIEMAESY LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA 

       310 
KFDEAIAETK RMKALA 

« Hide

References

[1]"Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials."
Turgut-Balik D., Shoemark D.K., Moreton K.M., Sessions R.B., Holbrook J.J.
Biotechnol. Lett. 23:917-921(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[2]"Determination of the DNA and aminoacid sequences of lactate dehydrogenase gene from Plasmodium falciparum strains K1 and PF FCBR: A route to the design of new antimalarials."
Turgut-Balik D., Holbrook J.J.
Turk. J. Biol. 25:241-250(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[3]"Cloning and sequence analysis of LDH gene of Plasmodium falciparum isolate FCC1/HN."
Shan Z.X., Yu X.B., Ma C.L., Chen S.Y., Bian G.W.
Zhongguo Re Dai Yi Xue 1:196-198(2001)
Cited for: NUCLEOTIDE SEQUENCE.
[4]Turgut-Balik D., Moreton K., Holbrook J.J.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[5]"Plasmodium falciparum: enhanced soluble expression, purification and biochemical characterization of lactate dehydrogenase."
Berwal R., Gopalan N., Chandel K., Prasad G.B., Prakash S.
Exp. Parasitol. 120:135-141(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Jind EMBL ABY76169.1.
[6]"The Apo Crystal Structure of Plasmodium Falciparum Lactate Dehydrogenase."
Birkinshaw R.W., Brady R.L.
Submitted (MAR-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
[7]"Genetic polymorphism analysis of pLDH from Indian isolates of P. falciparum and P. vivax."
Keluskar P., Gupta P., Singh V., Ingle S.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mzr-1 EMBL AEP83560.1 and Ori-1 EMBL AEP83559.1.
[8]"The Crystal Structure of Plasmodium Falciparum L- Lactate Dehydrogenase in Complex with a Novel Bicine Ligand."
Birkinshaw R.W., Brady R.L.
Submitted (AUG-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF251291 Genomic DNA. Translation: AAG14292.1.
DQ198261 Genomic DNA. Translation: ABA46354.1.
DQ198262 Genomic DNA. Translation: ABA46355.1.
EU330208 Genomic DNA. Translation: ABY76169.1.
JN547218 Genomic DNA. Translation: AEP83559.1.
JN547219 Genomic DNA. Translation: AEP83560.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2X8LX-ray1.60A1-316[»]
4B7UX-ray1.88A/B/C/D1-316[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ71T02.

Entry information

Entry nameQ71T02_PLAFA
AccessionPrimary (citable) accession number: Q71T02
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)