Q71T02 (Q71T02_PLAFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
L-lactate dehydrogenase EMBL AAG14292.1
EC=1.1.1.27 EMBL ABA46354.1

Submitted name:
Lactate dehydrogenase EMBL ABY76169.1
EC=1.1.1.27 EMBL ABY76169.1

Gene names

Name:	LDH-P EMBL AAG14292.1
Synonyms:	LDH EMBL ABA46354.1, ldh EMBL AEP83559.1

Organism

Plasmodium falciparum EMBL AAG14292.1

Taxonomic identifier

5833 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the LDH/MDH superfamily. RuleBase RU003369

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU003369 EMBL ABA46354.1
Technical term	3D-structure PDB 2X8L PDB 4B7U
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q71T02 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D25EB863954B8FC1	FASTA	316	34,108
	10 20 30 40 50 60 MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH TNVMAYSNCK 70 80 90 100 110 120 VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP LNNKIMIEIG GHIKKNCPNA 130 140 150 160 170 180 FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL GGVLDTSRLK YYISQKLNVC PRDVNAHIVG 190 200 210 220 230 240 AHGNKMVLLK RYITVGGIPL QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA 250 260 270 280 290 300 AAIIEMAESY LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA 310 KFDEAIAETK RMKALA

References

[1]	"Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials." Turgut-Balik D., Shoemark D.K., Moreton K.M., Sessions R.B., Holbrook J.J. Biotechnol. Lett. 23:917-921(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[2]	"Determination of the DNA and aminoacid sequences of lactate dehydrogenase gene from Plasmodium falciparum strains K1 and PF FCBR: A route to the design of new antimalarials." Turgut-Balik D., Holbrook J.J. Turk. J. Biol. 25:241-250(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[3]	"Cloning and sequence analysis of LDH gene of Plasmodium falciparum isolate FCC1/HN." Shan Z.X., Yu X.B., Ma C.L., Chen S.Y., Bian G.W. Zhongguo Re Dai Yi Xue 1:196-198(2001) Cited for: NUCLEOTIDE SEQUENCE.
[4]	Turgut-Balik D., Moreton K., Holbrook J.J. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: FCBR EMBL ABA46355.1 and K1 EMBL ABA46354.1.
[5]	"Plasmodium falciparum: enhanced soluble expression, purification and biochemical characterization of lactate dehydrogenase." Berwal R., Gopalan N., Chandel K., Prasad G.B., Prakash S. Exp. Parasitol. 120:135-141(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Jind EMBL ABY76169.1.
[6]	"The Apo Crystal Structure of Plasmodium Falciparum Lactate Dehydrogenase." Birkinshaw R.W., Brady R.L. Submitted (MAR-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
[7]	"Genetic polymorphism analysis of pLDH from Indian isolates of P. falciparum and P. vivax." Keluskar P., Gupta P., Singh V., Ingle S. Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mzr-1 EMBL AEP83560.1 and Ori-1 EMBL AEP83559.1.
[8]	"The Crystal Structure of Plasmodium Falciparum L- Lactate Dehydrogenase in Complex with a Novel Bicine Ligand." Birkinshaw R.W., Brady R.L. Submitted (AUG-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF251291 Genomic DNA. Translation: AAG14292.1.
DQ198261 Genomic DNA. Translation: ABA46354.1.
DQ198262 Genomic DNA. Translation: ABA46355.1.
EU330208 Genomic DNA. Translation: ABY76169.1.
JN547218 Genomic DNA. Translation: AEP83559.1.
JN547219 Genomic DNA. Translation: AEP83560.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2X8L	X-ray	1.60	A	1-316	[»]
4B7U	X-ray	1.88	A/B/C/D	1-316	[»]

SMR

Q71T02. Positions 2-316.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.40.50.720. 1 hit.
3.90.110.10. 1 hit.

InterPro

IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

PANTHER

PTHR11540. PTHR11540. 1 hit.

Pfam

PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000102. Lac_mal_DH. 1 hit.

PRINTS

PR00086. LLDHDRGNASE.

SUPFAM

SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q71T02.

Entry information

Entry name

Q71T02_PLAFA

Accession

Primary (citable) accession number: Q71T02

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)