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Q71T02

- Q71T02_PLAFA

UniProt

Q71T02 - Q71T02_PLAFA

Protein
Submitted name:

L-lactate dehydrogenase

Gene

LDH-P

Organism
Plasmodium falciparum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    L-lactate dehydrogenaseImported (EC:1.1.1.27Imported)
    Submitted name:
    Lactate dehydrogenaseImported (EC:1.1.1.27Imported)
    Gene namesi
    Name:LDH-PImported
    Synonyms:LDHImported, ldhImported
    OrganismiPlasmodium falciparumImported
    Taxonomic identifieri5833 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2X8LX-ray1.60A1-316[»]
    4B7UX-ray1.88A/B/C/D1-316[»]
    4PLZX-ray1.05A1-316[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ71T02.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily.UniRule annotation

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q71T02-1 [UniParc]FASTAAdd to Basket

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    MAPKAKIVLV GSGMIGGVMA TLIVQKNLGD VVLFDIVKNM PHGKALDTSH    50
    TNVMAYSNCK VSGSNTYDDL AGADVVIVTA GFTKAPGKSD KEWNRDDLLP 100
    LNNKIMIEIG GHIKKNCPNA FIIVVTNPVD VMVQLLHQHS GVPKNKIIGL 150
    GGVLDTSRLK YYISQKLNVC PRDVNAHIVG AHGNKMVLLK RYITVGGIPL 200
    QEFINNKLIS DAELEAIFDR TVNTALEIVN LHASPYVAPA AAIIEMAESY 250
    LKDLKKVLIC STLLEGQYGH SDIFGGTPVV LGANGVEQVI ELQLNSEEKA 300
    KFDEAIAETK RMKALA 316
    Length:316
    Mass (Da):34,108
    Last modified:July 5, 2004 - v1
    Checksum:iD25EB863954B8FC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251291 Genomic DNA. Translation: AAG14292.1.
    DQ198261 Genomic DNA. Translation: ABA46354.1.
    DQ198262 Genomic DNA. Translation: ABA46355.1.
    EU330208 Genomic DNA. Translation: ABY76169.1.
    JN547218 Genomic DNA. Translation: AEP83559.1.
    JN547219 Genomic DNA. Translation: AEP83560.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251291 Genomic DNA. Translation: AAG14292.1 .
    DQ198261 Genomic DNA. Translation: ABA46354.1 .
    DQ198262 Genomic DNA. Translation: ABA46355.1 .
    EU330208 Genomic DNA. Translation: ABY76169.1 .
    JN547218 Genomic DNA. Translation: AEP83559.1 .
    JN547219 Genomic DNA. Translation: AEP83560.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2X8L X-ray 1.60 A 1-316 [» ]
    4B7U X-ray 1.88 A/B/C/D 1-316 [» ]
    4PLZ X-ray 1.05 A 1-316 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q71T02.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials."
      Turgut-Balik D., Shoemark D.K., Moreton K.M., Sessions R.B., Holbrook J.J.
      Biotechnol. Lett. 23:917-921(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FCBRImported and K1Imported.
    2. "Determination of the DNA and aminoacid sequences of lactate dehydrogenase gene from Plasmodium falciparum strains K1 and PF FCBR: A route to the design of new antimalarials."
      Turgut-Balik D., Holbrook J.J.
      Turk. J. Biol. 25:241-250(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FCBRImported and K1Imported.
    3. "Cloning and sequence analysis of LDH gene of Plasmodium falciparum isolate FCC1/HN."
      Shan Z.X., Yu X.B., Ma C.L., Chen S.Y., Bian G.W.
      Zhongguo Re Dai Yi Xue 1:196-198(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Turgut-Balik D., Moreton K., Holbrook J.J.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FCBRImported and K1Imported.
    5. "Plasmodium falciparum: enhanced soluble expression, purification and biochemical characterization of lactate dehydrogenase."
      Berwal R., Gopalan N., Chandel K., Prasad G.B., Prakash S.
      Exp. Parasitol. 120:135-141(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JindImported.
    6. "The Apo Crystal Structure of Plasmodium Falciparum Lactate Dehydrogenase."
      Birkinshaw R.W., Brady R.L.
      Submitted (MAR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
    7. "The Crystal Structure of Plasmodium Falciparum L- Lactate Dehydrogenase in Complex with a Novel Bicine Ligand."
      Birkinshaw R.W., Brady R.L.
      Submitted (AUG-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS).
    8. "Plasmodium falciparum and Plasmodium vivax specific lactate dehydrogenase: Genetic polymorphism study from Indian isolates."
      Keluskar P., Singh V., Gupta P., Ingle S.
      Infect. Genet. Evol. 26:313-322(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Mzr-1Imported and Ori-1Imported.
    9. "An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactatedehydrogenases."
      Boucher J.I., Jacobowitz J.R., Beckett B.C., Classen S., Theobald D.L.
      Submitted (MAY-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS).

    Entry informationi

    Entry nameiQ71T02_PLAFA
    AccessioniPrimary (citable) accession number: Q71T02
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3