##gff-version 3 Q71SY5 UniProtKB Chain 1 747 . . . ID=PRO_0000304952;Note=Mediator of RNA polymerase II transcription subunit 25 Q71SY5 UniProtKB Region 1 226 . . . Note=Interaction with the Mediator complex Q71SY5 UniProtKB Region 233 274 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Region 299 390 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Region 389 543 . . . Note=Interaction with VP16 Q71SY5 UniProtKB Region 395 545 . . . Note=Interaction with CREBBP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17641689;Dbxref=PMID:17641689 Q71SY5 UniProtKB Region 548 747 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Region 564 653 . . . Note=Interaction with RARA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17641689;Dbxref=PMID:17641689 Q71SY5 UniProtKB Region 640 707 . . . Note=Interaction with RARA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17641689;Dbxref=PMID:17641689 Q71SY5 UniProtKB Motif 646 650 . . . Note=LXXLL motif Q71SY5 UniProtKB Compositional bias 319 345 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Compositional bias 577 607 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Compositional bias 608 638 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Compositional bias 649 712 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q71SY5 UniProtKB Modified residue 725 725 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VCB2 Q71SY5 UniProtKB Alternative sequence 61 273 . . . ID=VSP_047570;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 Q71SY5 UniProtKB Alternative sequence 303 319 . . . ID=VSP_028143;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q71SY5 UniProtKB Alternative sequence 716 747 . . . ID=VSP_028146;Note=In isoform 4. GQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI->AAKRKREGEGRVFREKWERAYFFVEVKSMPMCLICKQIVSVLKEYNLKRHYESKHSKSYDQYTEQTRRIRARPIWPDP;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.10 Q71SY5 UniProtKB Natural variant 39 39 . . . ID=VAR_073949;Note=In BVSYS%3B the mutation impairs interaction with the Mediator complex. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25792360;Dbxref=dbSNP:rs794729668,PMID:25792360 Q71SY5 UniProtKB Natural variant 140 140 . . . ID=VAR_073950;Note=Found in a patient with syndromic intellectual disability%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25527630;Dbxref=dbSNP:rs781140315,PMID:25527630 Q71SY5 UniProtKB Natural variant 335 335 . . . ID=VAR_063521;Note=In CMT2B2. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19290556;Dbxref=dbSNP:rs145770066,PMID:19290556 Q71SY5 UniProtKB Mutagenesis 646 646 . . . Note=Abrogates interaction with RARA. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17641689;Dbxref=PMID:17641689 Q71SY5 UniProtKB Mutagenesis 649 650 . . . Note=Abrogates interaction with RARA. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17641689;Dbxref=PMID:17641689 Q71SY5 UniProtKB Sequence conflict 20 20 . . . Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Sequence conflict 236 236 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Sequence conflict 268 268 . . . Note=V->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Sequence conflict 514 514 . . . Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Sequence conflict 536 536 . . . Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Sequence conflict 703 703 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q71SY5 UniProtKB Beta strand 16 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Turn 27 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 32 38 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 40 47 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 48 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 61 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 65 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 91 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 114 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 134 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 139 145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 159 161 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 166 174 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 175 177 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 179 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Helix 189 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 215 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 220 226 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EMF Q71SY5 UniProtKB Beta strand 396 409 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 414 417 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 424 434 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Helix 441 443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 446 454 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Helix 455 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Helix 462 465 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 466 475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 476 478 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L6U Q71SY5 UniProtKB Helix 480 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 494 499 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 502 504 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2L23 Q71SY5 UniProtKB Beta strand 510 515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Turn 517 519 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Beta strand 521 529 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6 Q71SY5 UniProtKB Helix 530 545 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KY6