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Protein

Mediator of RNA polymerase II transcription subunit 25

Gene

MED25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.3 Publications

GO - Molecular functioni

  • retinoic acid receptor binding Source: UniProtKB
  • retinoid X receptor binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • negative regulation of fibroblast proliferation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of cell cycle arrest Source: UniProtKB
  • positive regulation of chromatin binding Source: UniProtKB
  • positive regulation of mediator complex assembly Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 25
Alternative name(s):
Activator interaction domain-containing protein 1
Activator-recruited cofactor 92 kDa component
Short name:
ARC92
Mediator complex subunit 25
p78
Gene namesi
Name:MED25
Synonyms:ACID1, ARC92, PTOV2
ORF Names:TCBAP0758
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28845. MED25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Charcot-Marie-Tooth disease 2B2 (CMT2B2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA recessive axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
See also OMIM:605589
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063521335A → V in CMT2B2. 1 PublicationCorresponds to variant rs145770066dbSNPEnsembl.1
Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by eye, brain, cardiac and palatal abnormalities as well as growth retardation, microcephaly and severe intellectual disability.
See also OMIM:616449
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07394939Y → C in BVSYS; the mutation impairs interaction with the Mediator complex. 1 PublicationCorresponds to variant rs794729668dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi646L → A: Abrogates interaction with RARA. 1 Publication1
Mutagenesisi649 – 650LL → AA: Abrogates interaction with RARA. 1 Publication2

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Mental retardation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi81857.
MalaCardsiMED25.
MIMi605589. phenotype.
616449. phenotype.
OpenTargetsiENSG00000104973.
Orphaneti101101. Charcot-Marie-Tooth disease type 2B2.
PharmGKBiPA134984839.

Polymorphism and mutation databases

BioMutaiMED25.
DMDMi158706143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049521 – 747Mediator of RNA polymerase II transcription subunit 25Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei725Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ71SY5.
PaxDbiQ71SY5.
PeptideAtlasiQ71SY5.
PRIDEiQ71SY5.

PTM databases

iPTMnetiQ71SY5.
PhosphoSitePlusiQ71SY5.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen.2 Publications

Gene expression databases

BgeeiENSG00000104973.
CleanExiHS_MED25.
ExpressionAtlasiQ71SY5. baseline and differential.
GenevisibleiQ71SY5. HS.

Organism-specific databases

HPAiHPA068802.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CREBBP. Interacts with ESR1, GR, RARA, RXRA and THRB in a ligand-dependent fashion. Binds the Herpes simplex virus activator VP16.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MED15Q96RN52EBI-394558,EBI-394506
MED16Q9Y2X02EBI-394558,EBI-394541
RARAP1027610EBI-394558,EBI-413374
RXRAP197934EBI-394558,EBI-78598
RxraP287003EBI-394558,EBI-346715From a different organism.

GO - Molecular functioni

  • retinoic acid receptor binding Source: UniProtKB
  • retinoid X receptor binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123607. 46 interactors.
DIPiDIP-31454N.
IntActiQ71SY5. 31 interactors.
MINTiMINT-5209896.
STRINGi9606.ENSP00000326767.

Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi396 – 409Combined sources14
Beta strandi414 – 417Combined sources4
Beta strandi424 – 434Combined sources11
Helixi441 – 443Combined sources3
Beta strandi446 – 454Combined sources9
Helixi455 – 461Combined sources7
Helixi462 – 465Combined sources4
Beta strandi466 – 475Combined sources10
Beta strandi476 – 478Combined sources3
Helixi480 – 493Combined sources14
Beta strandi494 – 499Combined sources6
Beta strandi502 – 504Combined sources3
Beta strandi510 – 515Combined sources6
Turni517 – 519Combined sources3
Beta strandi521 – 529Combined sources9
Helixi530 – 545Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KY6NMR-A391-553[»]
2L23NMR-A391-548[»]
2L6UNMR-A391-543[»]
2XNFNMR-A394-543[»]
ProteinModelPortaliQ71SY5.
SMRiQ71SY5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ71SY5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 226Interaction with the Mediator complexAdd BLAST226
Regioni389 – 543Interaction with VP16Add BLAST155
Regioni395 – 545Interaction with CREBBP1 PublicationAdd BLAST151
Regioni564 – 653Interaction with RARA1 PublicationAdd BLAST90
Regioni640 – 707Interaction with RARA1 PublicationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi646 – 650LXXLL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 381Pro-richAdd BLAST182
Compositional biasi565 – 735Pro-richAdd BLAST171

Sequence similaritiesi

Belongs to the Mediator complex subunit 25 family.Curated

Phylogenomic databases

eggNOGiENOG410IHD9. Eukaryota.
ENOG410Z0HI. LUCA.
GeneTreeiENSGT00520000055653.
HOVERGENiHBG108127.
InParanoidiQ71SY5.
KOiK15168.
OMAiQQIGERG.
OrthoDBiEOG091G04LS.
PhylomeDBiQ71SY5.
TreeFamiTF329598.

Family and domain databases

InterProiIPR021394. Mediator_Med25.
IPR021406. Mediator_Med25_NR-box.
IPR021397. Mediator_Med25_SD1.
IPR021419. Mediator_Med25_VWA.
IPR002035. VWF_A.
[Graphical view]
PfamiPF11232. Med25. 1 hit.
PF11244. Med25_NR-box. 1 hit.
PF11235. Med25_SD1. 1 hit.
PF11265. Med25_VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q71SY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPGSEGPAR AGSVVADVVF VIEGTANLGP YFEGLRKHYL LPAIEYFNGG
60 70 80 90 100
PPAETDFGGD YGGTQYSLVV FNTVDCAPES YVQCHAPTSS AYEFVTWLDG
110 120 130 140 150
IKFMGGGGES CSLIAEGLST ALQLFDDFKK MREQIGQTHR VCLLICNSPP
160 170 180 190 200
YLLPAVESTT YSGCTTENLV QQIGERGIHF SIVSPRKLPA LRLLFEKAAP
210 220 230 240 250
PALLEPLQPP TDVSQDPRHM VLVRGLVLPV GGGSAPGPLQ SKQPVPLPPA
260 270 280 290 300
APSGATLSAA PQQPLPPVPP QYQVPGNLSA AQVAAQNAVE AAKNQKAGLG
310 320 330 340 350
PRFSPITPLQ QAAPGVGPPF SQAPAPQLPP GPPGAPKPPP ASQPSLVSTV
360 370 380 390 400
APGSGLAPTA QPGAPSMAGT VAPGGVSGPS PAQLGAPALG GQQSVSNKLL
410 420 430 440 450
AWSGVLEWQE KPKPASVDAN TKLTRSLPCQ VYVNHGENLK TEQWPQKLIM
460 470 480 490 500
QLIPQQLLTT LGPLFRNSRM VQFHFTNKDL ESLKGLYRIM GNGFAGCVHF
510 520 530 540 550
PHTAPCEVRV LMLLYSSKKK IFMGLIPYDQ SGFVNGIRQV ITNHKQVQQQ
560 570 580 590 600
KLEQQQRGMG GQQAPPGLGP ILEDQARPSQ NLLQLRPPQP QPQGTVGASG
610 620 630 640 650
ATGQPQPQGT AQPPPGAPQG PPGAASGPPP PGPILRPQNP GANPQLRSLL
660 670 680 690 700
LNPPPPQTGV PPPQASLHHL QPPGAPALLP PPHQGLGQPQ LGPPLLHPPP
710 720 730 740
AQSWPAQLPP RAPLPGQMLL SGGPRGPVPQ PGLQPSVMED DILMDLI
Length:747
Mass (Da):78,171
Last modified:October 2, 2007 - v2
Checksum:i6FE13FB45786402D
GO
Isoform 2 (identifier: Q71SY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     671-747: QPPGAPALLP...MEDDILMDLI → PSPGPHNFPL...ESPTPNKVPF

Show »
Length:754
Mass (Da):78,882
Checksum:i0E8022B21685A1EE
GO
Isoform 3 (identifier: Q71SY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-747: AQSWPAQLPP...MEDDILMDLI → PATRGSCAAA...VERIQPETPL

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):82,972
Checksum:i930FD1BDBEED7BA1
GO
Isoform 4 (identifier: Q71SY5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-747: GQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI → AAKRKREGEG...IRARPIWPDP

Note: No experimental confirmation available.
Show »
Length:793
Mass (Da):84,389
Checksum:i4F9597470EB0E517
GO
Isoform 5 (identifier: Q71SY5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-319: Missing.

Note: No experimental confirmation available.
Show »
Length:730
Mass (Da):76,512
Checksum:i70D41D4F28B8A709
GO
Isoform 6 (identifier: Q71SY5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-273: Missing.

Show »
Length:534
Mass (Da):55,456
Checksum:iD49EA118755469AC
GO

Sequence cautioni

The sequence AAG15589 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66680 differs from that shown. Reason: Frameshift at position 567.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20F → S in AAM20739 (PubMed:12163014).Curated1
Sequence conflicti236P → L in CAE84581 (PubMed:14657022).Curated1
Sequence conflicti236P → L in CAB66680 (Ref. 4) Curated1
Sequence conflicti268V → I in AAM20739 (PubMed:12163014).Curated1
Sequence conflicti514L → M in AAS45401 (PubMed:14983011).Curated1
Sequence conflicti536G → D in AAS45401 (PubMed:14983011).Curated1
Sequence conflicti703S → F in AAM20739 (PubMed:12163014).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07394939Y → C in BVSYS; the mutation impairs interaction with the Mediator complex. 1 PublicationCorresponds to variant rs794729668dbSNPEnsembl.1
Natural variantiVAR_073950140R → W Found in a patient with syndromic intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant rs781140315dbSNPEnsembl.1
Natural variantiVAR_063521335A → V in CMT2B2. 1 PublicationCorresponds to variant rs145770066dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04757061 – 273Missing in isoform 6. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_028143303 – 319Missing in isoform 5. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_028144671 – 747QPPGA…LMDLI → PSPGPHNFPLGLHCQVRGPG GGQRSGLSVPAAPGLEHQDQ VLLGSKDIGSKNEGSPSRAC SPASWRTTSSWISSESPTPN KVPF in isoform 2. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_028145701 – 747AQSWP…LMDLI → PATRGSCAAASAAPGPGAAP VGAPTPASTTCPVLARTTSP SGSTASGKTKERRRGPCVSR KMGASLFLCGSEEHAYVFNM QTNRVCVERIQPETPL in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_028146716 – 747GQMLL…LMDLI → AAKRKREGEGRVFREKWERA YFFVEVKSMPMCLICKQIVS VLKEYNLKRHYESKHSKSYD QYTEQTRRIRARPIWPDP in isoform 4. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261072 mRNA. Translation: AAM20739.1.
AJ617479 mRNA. Translation: CAE84581.1.
AY533507 mRNA. Translation: AAS45401.1.
AL136746 mRNA. Translation: CAB66680.1. Frameshift.
EU392500 mRNA. Translation: ACB88862.1.
AK289460 mRNA. Translation: BAF82149.1.
AC006942 Genomic DNA. Translation: AAD15565.1.
AC018766 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52546.1.
BC024312 mRNA. Translation: AAH24312.2.
BC065297 mRNA. Translation: AAH65297.1.
AF283769 mRNA. Translation: AAG15589.1. Different initiation.
CCDSiCCDS33075.1. [Q71SY5-1]
RefSeqiNP_112235.2. NM_030973.3. [Q71SY5-1]
UniGeneiHs.656639.
Hs.745568.

Genome annotation databases

EnsembliENST00000312865; ENSP00000326767; ENSG00000104973. [Q71SY5-1]
ENST00000538643; ENSP00000437496; ENSG00000104973. [Q71SY5-6]
GeneIDi81857.
KEGGihsa:81857.
UCSCiuc002ppw.3. human. [Q71SY5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261072 mRNA. Translation: AAM20739.1.
AJ617479 mRNA. Translation: CAE84581.1.
AY533507 mRNA. Translation: AAS45401.1.
AL136746 mRNA. Translation: CAB66680.1. Frameshift.
EU392500 mRNA. Translation: ACB88862.1.
AK289460 mRNA. Translation: BAF82149.1.
AC006942 Genomic DNA. Translation: AAD15565.1.
AC018766 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52546.1.
BC024312 mRNA. Translation: AAH24312.2.
BC065297 mRNA. Translation: AAH65297.1.
AF283769 mRNA. Translation: AAG15589.1. Different initiation.
CCDSiCCDS33075.1. [Q71SY5-1]
RefSeqiNP_112235.2. NM_030973.3. [Q71SY5-1]
UniGeneiHs.656639.
Hs.745568.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KY6NMR-A391-553[»]
2L23NMR-A391-548[»]
2L6UNMR-A391-543[»]
2XNFNMR-A394-543[»]
ProteinModelPortaliQ71SY5.
SMRiQ71SY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123607. 46 interactors.
DIPiDIP-31454N.
IntActiQ71SY5. 31 interactors.
MINTiMINT-5209896.
STRINGi9606.ENSP00000326767.

PTM databases

iPTMnetiQ71SY5.
PhosphoSitePlusiQ71SY5.

Polymorphism and mutation databases

BioMutaiMED25.
DMDMi158706143.

Proteomic databases

MaxQBiQ71SY5.
PaxDbiQ71SY5.
PeptideAtlasiQ71SY5.
PRIDEiQ71SY5.

Protocols and materials databases

DNASUi81857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312865; ENSP00000326767; ENSG00000104973. [Q71SY5-1]
ENST00000538643; ENSP00000437496; ENSG00000104973. [Q71SY5-6]
GeneIDi81857.
KEGGihsa:81857.
UCSCiuc002ppw.3. human. [Q71SY5-1]

Organism-specific databases

CTDi81857.
DisGeNETi81857.
GeneCardsiMED25.
GeneReviewsiMED25.
H-InvDBHIX0015345.
HGNCiHGNC:28845. MED25.
HPAiHPA068802.
MalaCardsiMED25.
MIMi605589. phenotype.
610197. gene.
616449. phenotype.
neXtProtiNX_Q71SY5.
OpenTargetsiENSG00000104973.
Orphaneti101101. Charcot-Marie-Tooth disease type 2B2.
PharmGKBiPA134984839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHD9. Eukaryota.
ENOG410Z0HI. LUCA.
GeneTreeiENSGT00520000055653.
HOVERGENiHBG108127.
InParanoidiQ71SY5.
KOiK15168.
OMAiQQIGERG.
OrthoDBiEOG091G04LS.
PhylomeDBiQ71SY5.
TreeFamiTF329598.

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

ChiTaRSiMED25. human.
EvolutionaryTraceiQ71SY5.
GeneWikiiMED25.
GenomeRNAii81857.
PROiQ71SY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104973.
CleanExiHS_MED25.
ExpressionAtlasiQ71SY5. baseline and differential.
GenevisibleiQ71SY5. HS.

Family and domain databases

InterProiIPR021394. Mediator_Med25.
IPR021406. Mediator_Med25_NR-box.
IPR021397. Mediator_Med25_SD1.
IPR021419. Mediator_Med25_VWA.
IPR002035. VWF_A.
[Graphical view]
PfamiPF11232. Med25. 1 hit.
PF11244. Med25_NR-box. 1 hit.
PF11235. Med25_SD1. 1 hit.
PF11265. Med25_VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMED25_HUMAN
AccessioniPrimary (citable) accession number: Q71SY5
Secondary accession number(s): A8K095
, B9TX30, O95783, Q6P143, Q6QMH5, Q707U4, Q8TB55, Q9H0L5, Q9HB34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.