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Q71SP6

- Q71SP6_HUMAN

UniProt

Q71SP6 - Q71SP6_HUMAN

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Protein
Submitted name: GTPase KRAS
Gene
KRAS
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. GDP binding Source: Ensembl
  2. GMP binding Source: Ensembl
  3. GTP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. Ras protein signal transduction Source: Ensembl
  3. actin cytoskeleton organization Source: Ensembl
  4. cell aging Source: Ensembl
  5. cell proliferation Source: Ensembl
  6. cytokine-mediated signaling pathway Source: Ensembl
  7. endocytosis Source: Ensembl
  8. intrinsic apoptotic signaling pathway Source: Ensembl
  9. negative regulation of neuron apoptotic process Source: Ensembl
  10. positive regulation of DNA replication Source: Ensembl
  11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  12. positive regulation of MAP kinase activity Source: Ensembl
  13. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  14. positive regulation of Rac protein signal transduction Source: Ensembl
  15. positive regulation of cell proliferation Source: Ensembl
  16. positive regulation of gene expression Source: Ensembl
  17. positive regulation of nitric-oxide synthase activity Source: Ensembl
  18. protein heterooligomerization Source: Ensembl
  19. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  20. regulation of synaptic transmission, GABAergic Source: Ensembl
  21. response to glucocorticoid Source: Ensembl
  22. response to mineralocorticoid Source: Ensembl
  23. social behavior Source: Ensembl
  24. striated muscle cell differentiation Source: Ensembl
  25. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRASImported
Submitted name:
K-ras p21 proteinImported
Submitted name:
K-ras proteinImported
Gene namesi
Name:KRASImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane raft Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ71SP6.

Expressioni

Gene expression databases

ArrayExpressiQ71SP6.
BgeeiQ71SP6.

Structurei

3D structure databases

ProteinModelPortaliQ71SP6.
SMRiQ71SP6. Positions 1-37.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q71SP6-1 [UniParc]FASTAAdd to Basket

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MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE                 37
Length:37
Mass (Da):4,037
Last modified:July 5, 2004 - v1
Checksum:iAAA5B411D73D686A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1.
EF685661 Genomic DNA. Translation: ABS10683.1.
EF685662 Genomic DNA. Translation: ABS10684.1.
JQ248012 Genomic DNA. Translation: AFF18187.1.
UniGeneiHs.37003.
Hs.486502.
Hs.505033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1 .
EF685661 Genomic DNA. Translation: ABS10683.1 .
EF685662 Genomic DNA. Translation: ABS10684.1 .
JQ248012 Genomic DNA. Translation: AFF18187.1 .
UniGenei Hs.37003.
Hs.486502.
Hs.505033.

3D structure databases

ProteinModelPortali Q71SP6.
SMRi Q71SP6. Positions 1-37.
ModBasei Search...

Proteomic databases

PRIDEi Q71SP6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi KRAS. human.

Gene expression databases

ArrayExpressi Q71SP6.
Bgeei Q71SP6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR."
    McKinzie P.B., Parsons B.L.
    Mutat. Res. 517:209-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of k-ras codon 12 mutations in pancreatic cancer."
    Iwasaki J.R., Arias-Stella J.L., Concha R., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Pancreatic tumorImported.
  3. Iwasaki J.R., Arevalo F.A., Li Ning E., Arias-Stella J.L., Yance T.C., Reinoso N.I., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  4. "p53 and cyclin D1 expression in adenomas of gallbladder."
    Arevalo F.A., Monge E., Leon R., Arias-Stella J.L.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  5. "Detection of KRAS Mutations in Colorectal Cancer by High Resolution Melting Analysis."
    Iwasaki J., Galvez-Philpott F., Arias Stella J.Jr.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Colorectal cancerImported.

Entry informationi

Entry nameiQ71SP6_HUMAN
AccessioniPrimary (citable) accession number: Q71SP6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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