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Q71SP6

- Q71SP6_HUMAN

UniProt

Q71SP6 - Q71SP6_HUMAN

Protein
Submitted name:

GTPase KRAS

Gene

KRAS

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. GDP binding Source: Ensembl
    2. GMP binding Source: Ensembl
    3. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. actin cytoskeleton organization Source: Ensembl
    2. cell aging Source: Ensembl
    3. cell proliferation Source: Ensembl
    4. cytokine-mediated signaling pathway Source: Ensembl
    5. endocytosis Source: Ensembl
    6. GTP catabolic process Source: InterPro
    7. intrinsic apoptotic signaling pathway Source: Ensembl
    8. negative regulation of neuron apoptotic process Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of DNA replication Source: Ensembl
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. positive regulation of gene expression Source: Ensembl
    13. positive regulation of MAP kinase activity Source: Ensembl
    14. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    15. positive regulation of nitric-oxide synthase activity Source: Ensembl
    16. positive regulation of Rac protein signal transduction Source: Ensembl
    17. protein heterooligomerization Source: Ensembl
    18. Ras protein signal transduction Source: Ensembl
    19. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    20. regulation of synaptic transmission, GABAergic Source: Ensembl
    21. response to glucocorticoid Source: Ensembl
    22. response to mineralocorticoid Source: Ensembl
    23. social behavior Source: Ensembl
    24. striated muscle cell differentiation Source: Ensembl
    25. visual learning Source: Ensembl

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    GTPase KRASImported
    Submitted name:
    K-ras p21 proteinImported
    Submitted name:
    K-ras proteinImported
    Gene namesi
    Name:KRASImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. membrane raft Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ71SP6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ71SP6.
    BgeeiQ71SP6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71SP6.
    SMRiQ71SP6. Positions 1-37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q71SP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE                 37
    Length:37
    Mass (Da):4,037
    Last modified:July 5, 2004 - v1
    Checksum:iAAA5B411D73D686A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei37 – 371Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285779 Genomic DNA. Translation: AAF91482.1.
    EF685661 Genomic DNA. Translation: ABS10683.1.
    EF685662 Genomic DNA. Translation: ABS10684.1.
    JQ248012 Genomic DNA. Translation: AFF18187.1.
    UniGeneiHs.37003.
    Hs.486502.
    Hs.505033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285779 Genomic DNA. Translation: AAF91482.1 .
    EF685661 Genomic DNA. Translation: ABS10683.1 .
    EF685662 Genomic DNA. Translation: ABS10684.1 .
    JQ248012 Genomic DNA. Translation: AFF18187.1 .
    UniGenei Hs.37003.
    Hs.486502.
    Hs.505033.

    3D structure databases

    ProteinModelPortali Q71SP6.
    SMRi Q71SP6. Positions 1-37.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q71SP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi KRAS. human.

    Gene expression databases

    ArrayExpressi Q71SP6.
    Bgeei Q71SP6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR."
      McKinzie P.B., Parsons B.L.
      Mutat. Res. 517:209-220(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Analysis of k-ras codon 12 mutations in pancreatic cancer."
      Iwasaki J.R., Arias-Stella J.L., Concha R., Arias Stella J.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Pancreatic tumorImported.
    3. Iwasaki J.R., Arevalo F.A., Li Ning E., Arias-Stella J.L., Yance T.C., Reinoso N.I., Arias Stella J.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Gallbladder tumorImported.
    4. "p53 and cyclin D1 expression in adenomas of gallbladder."
      Arevalo F.A., Monge E., Leon R., Arias-Stella J.L.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Gallbladder tumorImported.
    5. "Detection of KRAS Mutations in Colorectal Cancer by High Resolution Melting Analysis."
      Iwasaki J., Galvez-Philpott F., Arias Stella J.Jr.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Colorectal cancerImported.

    Entry informationi

    Entry nameiQ71SP6_HUMAN
    AccessioniPrimary (citable) accession number: Q71SP6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.