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Protein
Submitted name:

GTPase KRAS

Gene

KRAS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRASImported
Submitted name:
K-ras p21 proteinImported
Submitted name:
K-ras proteinImported
Gene namesi
Name:KRASImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ71SP6.

Expressioni

Gene expression databases

BgeeiQ71SP6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256078.

Structurei

3D structure databases

ProteinModelPortaliQ71SP6.
SMRiQ71SP6. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q71SP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE
Length:37
Mass (Da):4,037
Last modified:July 5, 2004 - v1
Checksum:iAAA5B411D73D686A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1.
EF685661 Genomic DNA. Translation: ABS10683.1.
EF685662 Genomic DNA. Translation: ABS10684.1.
JQ248012 Genomic DNA. Translation: AFF18187.1.
UniGeneiHs.37003.
Hs.486502.
Hs.505033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1.
EF685661 Genomic DNA. Translation: ABS10683.1.
EF685662 Genomic DNA. Translation: ABS10684.1.
JQ248012 Genomic DNA. Translation: AFF18187.1.
UniGeneiHs.37003.
Hs.486502.
Hs.505033.

3D structure databases

ProteinModelPortaliQ71SP6.
SMRiQ71SP6. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256078.

Proteomic databases

PRIDEiQ71SP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiKRAS. human.

Gene expression databases

BgeeiQ71SP6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR."
    McKinzie P.B., Parsons B.L.
    Mutat. Res. 517:209-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of k-ras codon 12 mutations in pancreatic cancer."
    Iwasaki J.R., Arias-Stella J.L., Concha R., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Pancreatic tumorImported.
  3. Iwasaki J.R., Arevalo F.A., Li Ning E., Arias-Stella J.L., Yance T.C., Reinoso N.I., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  4. "p53 and cyclin D1 expression in adenomas of gallbladder."
    Arevalo F.A., Monge E., Leon R., Arias-Stella J.L.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  5. "Detection of KRAS Mutations in Colorectal Cancer by High Resolution Melting Analysis."
    Iwasaki J., Galvez-Philpott F., Arias Stella J.Jr.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Colorectal cancerImported.

Entry informationi

Entry nameiQ71SP6_HUMAN
AccessioniPrimary (citable) accession number: Q71SP6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.