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Protein
Submitted name:

GTPase KRAS

Gene

KRAS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRASImported
Submitted name:
K-ras p21 proteinImported
Submitted name:
K-ras proteinImported
Gene namesi
Name:KRASImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ71SP6.
PRIDEiQ71SP6.

Expressioni

Gene expression databases

BgeeiQ71SP6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256078.

Structurei

3D structure databases

ProteinModelPortaliQ71SP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q71SP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIE
Length:37
Mass (Da):4,037
Last modified:July 5, 2004 - v1
Checksum:iAAA5B411D73D686A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1.
EF685661 Genomic DNA. Translation: ABS10683.1.
EF685662 Genomic DNA. Translation: ABS10684.1.
JQ248012 Genomic DNA. Translation: AFF18187.1.
UniGeneiHs.37003.
Hs.486502.
Hs.505033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285779 Genomic DNA. Translation: AAF91482.1.
EF685661 Genomic DNA. Translation: ABS10683.1.
EF685662 Genomic DNA. Translation: ABS10684.1.
JQ248012 Genomic DNA. Translation: AFF18187.1.
UniGeneiHs.37003.
Hs.486502.
Hs.505033.

3D structure databases

ProteinModelPortaliQ71SP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256078.

Proteomic databases

PaxDbiQ71SP6.
PRIDEiQ71SP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.

Miscellaneous databases

ChiTaRSiKRAS. human.

Gene expression databases

BgeeiQ71SP6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR."
    McKinzie P.B., Parsons B.L.
    Mutat. Res. 517:209-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Analysis of k-ras codon 12 mutations in pancreatic cancer."
    Iwasaki J.R., Arias-Stella J.L., Concha R., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Pancreatic tumorImported.
  3. Iwasaki J.R., Arevalo F.A., Li Ning E., Arias-Stella J.L., Yance T.C., Reinoso N.I., Arias Stella J.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  4. "p53 and cyclin D1 expression in adenomas of gallbladder."
    Arevalo F.A., Monge E., Leon R., Arias-Stella J.L.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Gallbladder tumorImported.
  5. "Detection of KRAS Mutations in Colorectal Cancer by High Resolution Melting Analysis."
    Iwasaki J., Galvez-Philpott F., Arias Stella J.Jr.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Colorectal cancerImported.

Entry informationi

Entry nameiQ71SP6_HUMAN
AccessioniPrimary (citable) accession number: Q71SP6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.