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Q71S95

- Q71S95_MOUSE

UniProt

Q71S95 - Q71S95_MOUSE

Protein
Submitted name:

Frizzled-10 like protein

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. Wnt-activated receptor activity Source: RefGenome
    3. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. brain development Source: RefGenome
    2. canonical Wnt signaling pathway Source: RefGenome
    3. gonad development Source: RefGenome
    4. negative regulation of Rho GTPase activity Source: Ensembl
    5. non-canonical Wnt signaling pathway via JNK cascade Source: Ensembl
    6. positive regulation of JUN kinase activity Source: Ensembl
    7. positive regulation of Rac GTPase activity Source: Ensembl
    8. regulation of actin cytoskeleton organization Source: Ensembl
    9. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    10. vasculature development Source: RefGenome
    11. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation, ReceptorSAAS annotation

    Keywords - Biological processi

    Wnt signaling pathwaySAAS annotation

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Frizzled-10 like proteinImported
    Gene namesi
    Name:Fzd10Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2136761. Fzd10.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cell surface Source: Ensembl
    3. cytoplasm Source: RefGenome
    4. integral component of membrane Source: UniProtKB-KW
    5. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiQ71S95.

    Expressioni

    Gene expression databases

    ArrayExpressiQ71S95.
    BgeeiQ71S95.
    GenevestigatoriQ71S95.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71S95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiQ71S95.
    PhylomeDBiQ71S95.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q71S95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMRGGPSRG AERGQQQQPV PGSGGPERRW DIAGATMQHP GPRLWLVLQV    50
    MIGSCTAISS MDLERPGDGK CQPVEIPMCK DIGYNTTRMP NLMGHENQRE 100
    AAIQLHEFAP LVEYGCHSHL RFFLCSLYAP MCTEQVSTPI PACRVMCEQA 150
    RLKCSPIMEQ FKFRWPDSLD CSKLPNKNDP NYLCMEAPNN GSDEPSRGSG 200
    MFPPLFRPQR PHSAQEHPLK DGGPGRAGCD NPGKFHHVEK SESCAPLCTP 250
    GVDVYWSRDD KRFAVVWLAI WSVLCFFSSA FTVLTFLIDP SRFRYPERPI 300
    IFLSMCYCVY SVGYIIRLFA GAESIACDRD SGQLYVIQEG LESTGCTLVF 350
    LVLYYFGMAS SLWWVVLTLT WFLAAGKKWG HEAIEANSSY FHLAAWAIPA 400
    VKTILILVMR RVAGDELTGV CYVGSMDVNA LTGFVLVPLA CYLVIGTSFI 450
    LSGFVALFHI RRVMKTGGEN TDKLEKLMVR IGVFSLLYTV PATCVIACYF 500
    YERLNMDYWK MLATQHKCKM NNQTKTPDCL MTTSIPAVEV FMVKVSMLLV 550
    VGITSGVWVW TSKTLQSWQH VCSRGLKRKS RRKPASVVTS AGIYKKAQHP 600
    QKPHLGKYEL PAQPSACV 618
    Length:618
    Mass (Da):69,036
    Last modified:July 5, 2004 - v1
    Checksum:iA1B2F98C1C0D3738
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF310970 mRNA. Translation: AAQ14553.1.
    UniGeneiMm.197628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF310970 mRNA. Translation: AAQ14553.1 .
    UniGenei Mm.197628.

    3D structure databases

    ProteinModelPortali Q71S95.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I93.001.

    Proteomic databases

    PRIDEi Q71S95.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2136761. Fzd10.

    Phylogenomic databases

    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi Q71S95.
    PhylomeDBi Q71S95.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q71S95.
    Bgeei Q71S95.
    Genevestigatori Q71S95.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026549. FZD10.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF86. PTHR11309:SF86. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a mouse homolog of Frizzled-10."
      Yoshikawa Y., Shiraga H., Kawakami Y., Nohno T., Takada S.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ71S95_MOUSE
    AccessioniPrimary (citable) accession number: Q71S95
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)