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Protein
Submitted name:

Frizzled-10 like protein

Gene

Fzd10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GO_Central
  2. Wnt-activated receptor activity Source: GO_Central
  3. Wnt-protein binding Source: MGI

GO - Biological processi

  1. canonical Wnt signaling pathway Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GOC
  3. multicellular organismal development Source: UniProtKB-KW
  4. negative regulation of Rho GTPase activity Source: MGI
  5. non-canonical Wnt signaling pathway Source: GO_Central
  6. non-canonical Wnt signaling pathway via JNK cascade Source: MGI
  7. positive regulation of JUN kinase activity Source: MGI
  8. positive regulation of Rac GTPase activity Source: MGI
  9. regulation of actin cytoskeleton organization Source: MGI
  10. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Submitted name:
Frizzled-10 like proteinImported
Gene namesi
Name:Fzd10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2136761. Fzd10.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ71S95.

Expressioni

Gene expression databases

BgeeiQ71S95.
ExpressionAtlasiQ71S95. baseline and differential.
GenevestigatoriQ71S95.

Structurei

3D structure databases

ProteinModelPortaliQ71S95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000233236.
HOVERGENiHBG006977.
PhylomeDBiQ71S95.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71S95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGMRGGPSRG AERGQQQQPV PGSGGPERRW DIAGATMQHP GPRLWLVLQV
60 70 80 90 100
MIGSCTAISS MDLERPGDGK CQPVEIPMCK DIGYNTTRMP NLMGHENQRE
110 120 130 140 150
AAIQLHEFAP LVEYGCHSHL RFFLCSLYAP MCTEQVSTPI PACRVMCEQA
160 170 180 190 200
RLKCSPIMEQ FKFRWPDSLD CSKLPNKNDP NYLCMEAPNN GSDEPSRGSG
210 220 230 240 250
MFPPLFRPQR PHSAQEHPLK DGGPGRAGCD NPGKFHHVEK SESCAPLCTP
260 270 280 290 300
GVDVYWSRDD KRFAVVWLAI WSVLCFFSSA FTVLTFLIDP SRFRYPERPI
310 320 330 340 350
IFLSMCYCVY SVGYIIRLFA GAESIACDRD SGQLYVIQEG LESTGCTLVF
360 370 380 390 400
LVLYYFGMAS SLWWVVLTLT WFLAAGKKWG HEAIEANSSY FHLAAWAIPA
410 420 430 440 450
VKTILILVMR RVAGDELTGV CYVGSMDVNA LTGFVLVPLA CYLVIGTSFI
460 470 480 490 500
LSGFVALFHI RRVMKTGGEN TDKLEKLMVR IGVFSLLYTV PATCVIACYF
510 520 530 540 550
YERLNMDYWK MLATQHKCKM NNQTKTPDCL MTTSIPAVEV FMVKVSMLLV
560 570 580 590 600
VGITSGVWVW TSKTLQSWQH VCSRGLKRKS RRKPASVVTS AGIYKKAQHP
610
QKPHLGKYEL PAQPSACV
Length:618
Mass (Da):69,036
Last modified:July 5, 2004 - v1
Checksum:iA1B2F98C1C0D3738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310970 mRNA. Translation: AAQ14553.1.
UniGeneiMm.197628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF310970 mRNA. Translation: AAQ14553.1.
UniGeneiMm.197628.

3D structure databases

ProteinModelPortaliQ71S95.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI93.001.

Proteomic databases

PRIDEiQ71S95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2136761. Fzd10.

Phylogenomic databases

HOGENOMiHOG000233236.
HOVERGENiHBG006977.
PhylomeDBiQ71S95.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ71S95.
ExpressionAtlasiQ71S95. baseline and differential.
GenevestigatoriQ71S95.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026549. FZD10.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF86. PTHR11309:SF86. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a mouse homolog of Frizzled-10."
    Yoshikawa Y., Shiraga H., Kawakami Y., Nohno T., Takada S.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ71S95_MOUSE
AccessioniPrimary (citable) accession number: Q71S95
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.