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Protein

ATP synthase F(0) complex subunit C3, mitochondrial

Gene

Atp5mc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei125Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP synthesis coupled proton transport Source: GO_Central
  • response to ethanol Source: RGD

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C3, mitochondrialCurated
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase membrane subunit c locus 3Imported
ATP synthase proteolipid P3
ATPase protein 9
ATPase subunit c
Gene namesi
Name:Atp5mc3Imported
Synonyms:Atp5g3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620052 Atp5mc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 67MitochondrionBy similarityAdd BLAST67
ChainiPRO_000000257068 – 142ATP synthase F(0) complex subunit C3, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiQ71S46
PRIDEiQ71S46

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

CORUMiQ71S46
STRINGi10116.ENSRNOP00000055032

Structurei

3D structure databases

ProteinModelPortaliQ71S46
SMRiQ71S46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025 Eukaryota
COG0636 LUCA
HOGENOMiHOG000235246
HOVERGENiHBG050605
InParanoidiQ71S46
KOiK02128
PhylomeDBiQ71S46

Family and domain databases

Gene3Di1.20.20.10, 1 hit
HAMAPiMF_01396 ATP_synth_c_bact, 1 hit
InterProiView protein in InterPro
IPR000454 ATP_synth_F0_csu
IPR020537 ATP_synth_F0_csu_DDCD_BS
IPR038662 ATP_synth_F0_csu_sf
IPR002379 ATPase_proteolipid_c-like_dom
IPR035921 F/V-ATP_Csub_sf
PANTHERiPTHR10031 PTHR10031, 1 hit
PfamiView protein in Pfam
PF00137 ATP-synt_C, 1 hit
PRINTSiPR00124 ATPASEC
SUPFAMiSSF81333 SSF81333, 1 hit
PROSITEiView protein in PROSITE
PS00605 ATPASE_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q71S46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFACAKLACT PSLIRAGSRV AYRPISASVL SRPEASRTGE GSTVFNGAQN
60 70 80 90 100
GVSQLIQREF QTSAISRDID TAAKFIGAGA ATVGVAGSGA GIGTVFGSLI
110 120 130 140
IGYARNPSLK QQLFSYAILG FALSEAMGLF CLMVAFLILF AM
Length:142
Mass (Da):14,693
Last modified:July 5, 2004 - v1
Checksum:i19EC0D1710A0AA3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315374 mRNA Translation: AAG60677.1
RefSeqiNP_446208.1, NM_053756.1
UniGeneiRn.2180

Genome annotation databases

GeneIDi114630
KEGGirno:114630
UCSCiRGD:620052 rat

Similar proteinsi

Entry informationi

Entry nameiAT5G3_RAT
AccessioniPrimary (citable) accession number: Q71S46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health