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Protein

Voltage-dependent calcium channel gamma-2 subunit

Gene

Cacng2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.5 Publications

GO - Molecular functioni

  • calcium channel regulator activity Source: RGD
  • channel regulator activity Source: GO_Central
  • ionotropic glutamate receptor binding Source: RGD
  • voltage-gated calcium channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-RNO-399719. Trafficking of AMPA receptors.
R-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-2 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-2 subunit
Stargazin1 Publication
Transmembrane AMPAR regulatory protein gamma-2
Short name:
TARP gamma-21 Publication
Gene namesi
Name:Cacng2Imported
Synonyms:StgCurated
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi71095. Cacng2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004089731 – 323Voltage-dependent calcium channel gamma-2 subunitAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Modified residuei253PhosphoserineCombined sources1
Modified residuei271PhosphotyrosineBy similarity1
Modified residuei321Phosphothreonine; by PKABy similarity1

Post-translational modificationi

Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ71RJ2.
PRIDEiQ71RJ2.

PTM databases

iPTMnetiQ71RJ2.
PhosphoSitePlusiQ71RJ2.
SwissPalmiQ71RJ2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006226.
GenevisibleiQ71RJ2. RN.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97 (PubMed:27756895). May interact with GOPC (By similarity). Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1 and GRIA2 (PubMed:27756895). Interacts with MPP2 (PubMed:27756895).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD

Protein-protein interaction databases

DIPiDIP-41720N.
IntActiQ71RJ2. 3 interactors.
MINTiMINT-1784279.
STRINGi10116.ENSRNOP00000008414.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KK2electron microscopy7.30E/F/G/H1-323[»]
ProteinModelPortaliQ71RJ2.
SMRiQ71RJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNQ. Eukaryota.
ENOG4110ISU. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ71RJ2.
OMAiNARATDY.
OrthoDBiEOG091G0D2Z.
PhylomeDBiQ71RJ2.
TreeFamiTF327980.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR005422. VDCC_g2su.
IPR008368. VDCC_gsu.
PANTHERiPTHR12107:SF17. PTHR12107:SF17. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01602. VDCCGAMMA2.

Sequencei

Sequence statusi: Complete.

Q71RJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFDRGVQM LLTTVGAFAA FSLMTIAVGT DYWLYSRGVC KTKSVSENET
60 70 80 90 100
SKKNEEVMTH SGLWRTCCLE GNFKGLCKQI DHFPEDADYE ADTAEYFLRA
110 120 130 140 150
VRASSIFPIL SVILLFMGGL CIAASEFYKT RHNIILSAGI FFVSAGLSNI
160 170 180 190 200
IGIIVYISAN AGDPSKSDSK KNSYSYGWSF YFGALSFIIA EMVGVLAVHM
210 220 230 240 250
FIDRHKQLRA TARATDYLQA SAITRIPSYR YRYQRRSRSS SRSTEPSHSR
260 270 280 290 300
DASPVGVKGF NTLPSTEISM YTLSRDPLKA ATTPTATYNS DRDNSFLQVH
310 320
NCIQKDSKDS LHANTANRRT TPV
Length:323
Mass (Da):35,895
Last modified:July 5, 2004 - v1
Checksum:iAA9D475606A0FBA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361339 mRNA. Translation: AAL50034.1.
CH473950 Genomic DNA. Translation: EDM15892.1.
UniGeneiRn.72939.

Genome annotation databases

EnsembliENSRNOT00000008414; ENSRNOP00000008414; ENSRNOG00000006226.
UCSCiRGD:71095. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361339 mRNA. Translation: AAL50034.1.
CH473950 Genomic DNA. Translation: EDM15892.1.
UniGeneiRn.72939.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KK2electron microscopy7.30E/F/G/H1-323[»]
ProteinModelPortaliQ71RJ2.
SMRiQ71RJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-41720N.
IntActiQ71RJ2. 3 interactors.
MINTiMINT-1784279.
STRINGi10116.ENSRNOP00000008414.

PTM databases

iPTMnetiQ71RJ2.
PhosphoSitePlusiQ71RJ2.
SwissPalmiQ71RJ2.

Proteomic databases

PaxDbiQ71RJ2.
PRIDEiQ71RJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008414; ENSRNOP00000008414; ENSRNOG00000006226.
UCSCiRGD:71095. rat.

Organism-specific databases

RGDi71095. Cacng2.

Phylogenomic databases

eggNOGiENOG410IFNQ. Eukaryota.
ENOG4110ISU. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233440.
HOVERGENiHBG003682.
InParanoidiQ71RJ2.
OMAiNARATDY.
OrthoDBiEOG091G0D2Z.
PhylomeDBiQ71RJ2.
TreeFamiTF327980.

Enzyme and pathway databases

ReactomeiR-RNO-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-RNO-399719. Trafficking of AMPA receptors.
R-RNO-5576892. Phase 0 - rapid depolarisation.
R-RNO-5576893. Phase 2 - plateau phase.
R-RNO-5682910. LGI-ADAM interactions.

Miscellaneous databases

PROiPR:Q71RJ2.

Gene expression databases

BgeeiENSRNOG00000006226.
GenevisibleiQ71RJ2. RN.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR005422. VDCC_g2su.
IPR008368. VDCC_gsu.
PANTHERiPTHR12107:SF17. PTHR12107:SF17. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01602. VDCCGAMMA2.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG2_RAT
AccessioniPrimary (citable) accession number: Q71RJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.