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Protein

Transmembrane and ubiquitin-like domain-containing protein 2

Gene

TMUB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and ubiquitin-like domain-containing protein 2
Gene namesi
Name:TMUB2
ORF Names:FP2653, UNQ1897/PRO4343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28459. TMUB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168591.
PharmGKBiPA145147917.

Polymorphism and mutation databases

BioMutaiTMUB2.
DMDMi110287995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002453121 – 321Transmembrane and ubiquitin-like domain-containing protein 2Add BLAST321

Proteomic databases

EPDiQ71RG4.
MaxQBiQ71RG4.
PaxDbiQ71RG4.
PeptideAtlasiQ71RG4.
PRIDEiQ71RG4.

PTM databases

iPTMnetiQ71RG4.
PhosphoSitePlusiQ71RG4.

Expressioni

Gene expression databases

BgeeiENSG00000168591.
CleanExiHS_TMUB2.
ExpressionAtlasiQ71RG4. baseline and differential.
GenevisibleiQ71RG4. HS.

Organism-specific databases

HPAiHPA043137.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-2820477,EBI-747430
SGTAO437653EBI-2820477,EBI-347996
UBQLN1Q9UMX0-23EBI-2820477,EBI-10173939

Protein-protein interaction databases

BioGridi122537. 11 interactors.
DIPiDIP-60896N.
IntActiQ71RG4. 4 interactors.
MINTiMINT-4722595.
STRINGi9606.ENSP00000444565.

Structurei

3D structure databases

ProteinModelPortaliQ71RG4.
SMRiQ71RG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 247Ubiquitin-likePROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG1T. Eukaryota.
ENOG4111WH7. LUCA.
GeneTreeiENSGT00390000014069.
HOGENOMiHOG000232067.
HOVERGENiHBG050920.
InParanoidiQ71RG4.
OMAiPVSSQAM.
OrthoDBiEOG091G0NYR.
PhylomeDBiQ71RG4.
TreeFamiTF329265.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q71RG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV
60 70 80 90 100
LAWLSTYVAD SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP
110 120 130 140 150
HPSEGNDEKA EEAGEGRGDS TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA
160 170 180 190 200
GSSSPEAPLR SEDSTCLPPS PGLITVRLKF LNDTEELAVA RPEDTVGALK
210 220 230 240 250
SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC HRSPPGSAVP
260 270 280 290 300
GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA
310 320
TVSLVGVTVF FSFLVFGMYG R
Length:321
Mass (Da):33,788
Last modified:July 11, 2006 - v2
Checksum:iC48656AD40A72454
GO
Isoform 2 (identifier: Q71RG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:301
Mass (Da):31,607
Checksum:i25469114D9C227BF
GO
Isoform 3 (identifier: Q71RG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     201-201: S → R
     202-321: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):18,542
Checksum:i5F40EF668D941650
GO
Isoform 4 (identifier: Q71RG4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     105-114: GNDEKAEEAG → ANTSLDKKAR
     115-321: Missing.

Note: No experimental confirmation available.
Show »
Length:94
Mass (Da):9,709
Checksum:iC9FF0962A4DF1FE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265S → R in CAD38755 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052695228R → H.Corresponds to variant rs9895154dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197001 – 20Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsAdd BLAST20
Alternative sequenceiVSP_019701105 – 114GNDEKAEEAG → ANTSLDKKAR in isoform 4. 1 Publication10
Alternative sequenceiVSP_019702115 – 321Missing in isoform 4. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_019703201S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_019704202 – 321Missing in isoform 3. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370373 mRNA. Translation: AAQ15209.1.
AY358780 mRNA. Translation: AAQ89140.1.
AK021759 mRNA. Translation: BAB13886.1.
AK096631 mRNA. Translation: BAG53343.1.
CR622157 mRNA. No translation available.
AL833899 mRNA. Translation: CAD38755.1.
BC001792 mRNA. Translation: AAH01792.1.
BC004306 mRNA. Translation: AAH04306.1.
BC063489 mRNA. Translation: AAH63489.1.
CCDSiCCDS11479.1. [Q71RG4-2]
CCDS54134.1. [Q71RG4-1]
RefSeqiNP_001070142.1. NM_001076674.1. [Q71RG4-1]
NP_001317164.1. NM_001330235.1.
NP_077012.2. NM_024107.2. [Q71RG4-2]
NP_803190.2. NM_177441.2. [Q71RG4-2]
XP_011523500.1. XM_011525198.2. [Q71RG4-1]
XP_011523503.1. XM_011525201.2. [Q71RG4-1]
XP_011523507.1. XM_011525205.2. [Q71RG4-2]
XP_011523508.1. XM_011525206.2. [Q71RG4-2]
XP_011523509.1. XM_011525207.2. [Q71RG4-2]
XP_011523510.1. XM_011525208.2. [Q71RG4-2]
XP_011523511.1. XM_011525209.2. [Q71RG4-2]
XP_016880537.1. XM_017025048.1. [Q71RG4-2]
XP_016880538.1. XM_017025049.1. [Q71RG4-2]
XP_016880539.1. XM_017025050.1. [Q71RG4-2]
XP_016880540.1. XM_017025051.1. [Q71RG4-2]
UniGeneiHs.181391.

Genome annotation databases

EnsembliENST00000319511; ENSP00000313214; ENSG00000168591. [Q71RG4-2]
ENST00000357984; ENSP00000350672; ENSG00000168591. [Q71RG4-2]
ENST00000538716; ENSP00000444565; ENSG00000168591. [Q71RG4-1]
ENST00000587172; ENSP00000465153; ENSG00000168591. [Q71RG4-4]
ENST00000587989; ENSP00000466971; ENSG00000168591. [Q71RG4-1]
ENST00000589785; ENSP00000467364; ENSG00000168591. [Q71RG4-2]
ENST00000589856; ENSP00000467960; ENSG00000168591. [Q71RG4-3]
ENST00000590235; ENSP00000465015; ENSG00000168591. [Q71RG4-4]
ENST00000592825; ENSP00000466189; ENSG00000168591. [Q71RG4-4]
GeneIDi79089.
KEGGihsa:79089.
UCSCiuc002ifo.4. human. [Q71RG4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370373 mRNA. Translation: AAQ15209.1.
AY358780 mRNA. Translation: AAQ89140.1.
AK021759 mRNA. Translation: BAB13886.1.
AK096631 mRNA. Translation: BAG53343.1.
CR622157 mRNA. No translation available.
AL833899 mRNA. Translation: CAD38755.1.
BC001792 mRNA. Translation: AAH01792.1.
BC004306 mRNA. Translation: AAH04306.1.
BC063489 mRNA. Translation: AAH63489.1.
CCDSiCCDS11479.1. [Q71RG4-2]
CCDS54134.1. [Q71RG4-1]
RefSeqiNP_001070142.1. NM_001076674.1. [Q71RG4-1]
NP_001317164.1. NM_001330235.1.
NP_077012.2. NM_024107.2. [Q71RG4-2]
NP_803190.2. NM_177441.2. [Q71RG4-2]
XP_011523500.1. XM_011525198.2. [Q71RG4-1]
XP_011523503.1. XM_011525201.2. [Q71RG4-1]
XP_011523507.1. XM_011525205.2. [Q71RG4-2]
XP_011523508.1. XM_011525206.2. [Q71RG4-2]
XP_011523509.1. XM_011525207.2. [Q71RG4-2]
XP_011523510.1. XM_011525208.2. [Q71RG4-2]
XP_011523511.1. XM_011525209.2. [Q71RG4-2]
XP_016880537.1. XM_017025048.1. [Q71RG4-2]
XP_016880538.1. XM_017025049.1. [Q71RG4-2]
XP_016880539.1. XM_017025050.1. [Q71RG4-2]
XP_016880540.1. XM_017025051.1. [Q71RG4-2]
UniGeneiHs.181391.

3D structure databases

ProteinModelPortaliQ71RG4.
SMRiQ71RG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122537. 11 interactors.
DIPiDIP-60896N.
IntActiQ71RG4. 4 interactors.
MINTiMINT-4722595.
STRINGi9606.ENSP00000444565.

PTM databases

iPTMnetiQ71RG4.
PhosphoSitePlusiQ71RG4.

Polymorphism and mutation databases

BioMutaiTMUB2.
DMDMi110287995.

Proteomic databases

EPDiQ71RG4.
MaxQBiQ71RG4.
PaxDbiQ71RG4.
PeptideAtlasiQ71RG4.
PRIDEiQ71RG4.

Protocols and materials databases

DNASUi79089.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319511; ENSP00000313214; ENSG00000168591. [Q71RG4-2]
ENST00000357984; ENSP00000350672; ENSG00000168591. [Q71RG4-2]
ENST00000538716; ENSP00000444565; ENSG00000168591. [Q71RG4-1]
ENST00000587172; ENSP00000465153; ENSG00000168591. [Q71RG4-4]
ENST00000587989; ENSP00000466971; ENSG00000168591. [Q71RG4-1]
ENST00000589785; ENSP00000467364; ENSG00000168591. [Q71RG4-2]
ENST00000589856; ENSP00000467960; ENSG00000168591. [Q71RG4-3]
ENST00000590235; ENSP00000465015; ENSG00000168591. [Q71RG4-4]
ENST00000592825; ENSP00000466189; ENSG00000168591. [Q71RG4-4]
GeneIDi79089.
KEGGihsa:79089.
UCSCiuc002ifo.4. human. [Q71RG4-1]

Organism-specific databases

CTDi79089.
GeneCardsiTMUB2.
H-InvDBHIX0013877.
HGNCiHGNC:28459. TMUB2.
HPAiHPA043137.
neXtProtiNX_Q71RG4.
OpenTargetsiENSG00000168591.
PharmGKBiPA145147917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG1T. Eukaryota.
ENOG4111WH7. LUCA.
GeneTreeiENSGT00390000014069.
HOGENOMiHOG000232067.
HOVERGENiHBG050920.
InParanoidiQ71RG4.
OMAiPVSSQAM.
OrthoDBiEOG091G0NYR.
PhylomeDBiQ71RG4.
TreeFamiTF329265.

Miscellaneous databases

ChiTaRSiTMUB2. human.
GeneWikiiTMUB2.
GenomeRNAii79089.
PROiQ71RG4.

Gene expression databases

BgeeiENSG00000168591.
CleanExiHS_TMUB2.
ExpressionAtlasiQ71RG4. baseline and differential.
GenevisibleiQ71RG4. HS.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMUB2_HUMAN
AccessioniPrimary (citable) accession number: Q71RG4
Secondary accession number(s): B3KU81
, Q8NDI2, Q9BPZ5, Q9HAG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.