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Protein

Transmembrane and ubiquitin-like domain-containing protein 2

Gene

TMUB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and ubiquitin-like domain-containing protein 2
Gene namesi
Name:TMUB2
ORF Names:FP2653, UNQ1897/PRO4343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28459. TMUB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147917.

Polymorphism and mutation databases

BioMutaiTMUB2.
DMDMi110287995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Transmembrane and ubiquitin-like domain-containing protein 2PRO_0000245312Add
BLAST

Proteomic databases

EPDiQ71RG4.
MaxQBiQ71RG4.
PaxDbiQ71RG4.
PRIDEiQ71RG4.

PTM databases

iPTMnetiQ71RG4.
PhosphoSiteiQ71RG4.

Expressioni

Gene expression databases

BgeeiQ71RG4.
CleanExiHS_TMUB2.
ExpressionAtlasiQ71RG4. baseline and differential.
GenevisibleiQ71RG4. HS.

Organism-specific databases

HPAiHPA043137.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-2820477,EBI-747430
SGTAO437653EBI-2820477,EBI-347996
UBQLN1Q9UMX0-23EBI-2820477,EBI-10173939

Protein-protein interaction databases

BioGridi122537. 11 interactions.
DIPiDIP-60896N.
IntActiQ71RG4. 4 interactions.
MINTiMINT-4722595.
STRINGi9606.ENSP00000444565.

Structurei

3D structure databases

ProteinModelPortaliQ71RG4.
SMRiQ71RG4. Positions 174-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 24774Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG1T. Eukaryota.
ENOG4111WH7. LUCA.
GeneTreeiENSGT00390000014069.
HOGENOMiHOG000232067.
HOVERGENiHBG050920.
InParanoidiQ71RG4.
OMAiPVSSQAM.
PhylomeDBiQ71RG4.
TreeFamiTF329265.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q71RG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISRHLQNNL MSVDPASSQA MELSDVTLIE GVGNEVMVVA GVVVLILALV
60 70 80 90 100
LAWLSTYVAD SGSNQLLGAI VSAGDTSVLH LGHVDHLVAG QGNPEPTELP
110 120 130 140 150
HPSEGNDEKA EEAGEGRGDS TGEAGAGGGV EPSLEHLLDI QGLPKRQAGA
160 170 180 190 200
GSSSPEAPLR SEDSTCLPPS PGLITVRLKF LNDTEELAVA RPEDTVGALK
210 220 230 240 250
SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC HRSPPGSAVP
260 270 280 290 300
GPSASLAPSA TEPPSLGVNV GSLMVPVFVV LLGVVWYFRI NYRQFFTAPA
310 320
TVSLVGVTVF FSFLVFGMYG R
Length:321
Mass (Da):33,788
Last modified:July 11, 2006 - v2
Checksum:iC48656AD40A72454
GO
Isoform 2 (identifier: Q71RG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:301
Mass (Da):31,607
Checksum:i25469114D9C227BF
GO
Isoform 3 (identifier: Q71RG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     201-201: S → R
     202-321: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):18,542
Checksum:i5F40EF668D941650
GO
Isoform 4 (identifier: Q71RG4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     105-114: GNDEKAEEAG → ANTSLDKKAR
     115-321: Missing.

Note: No experimental confirmation available.
Show »
Length:94
Mass (Da):9,709
Checksum:iC9FF0962A4DF1FE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651S → R in CAD38755 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281R → H.
Corresponds to variant rs9895154 [ dbSNP | Ensembl ].
VAR_052695

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_019700Add
BLAST
Alternative sequencei105 – 11410GNDEKAEEAG → ANTSLDKKAR in isoform 4. 1 PublicationVSP_019701
Alternative sequencei115 – 321207Missing in isoform 4. 1 PublicationVSP_019702Add
BLAST
Alternative sequencei201 – 2011S → R in isoform 3. 1 PublicationVSP_019703
Alternative sequencei202 – 321120Missing in isoform 3. 1 PublicationVSP_019704Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370373 mRNA. Translation: AAQ15209.1.
AY358780 mRNA. Translation: AAQ89140.1.
AK021759 mRNA. Translation: BAB13886.1.
AK096631 mRNA. Translation: BAG53343.1.
CR622157 mRNA. No translation available.
AL833899 mRNA. Translation: CAD38755.1.
BC001792 mRNA. Translation: AAH01792.1.
BC004306 mRNA. Translation: AAH04306.1.
BC063489 mRNA. Translation: AAH63489.1.
CCDSiCCDS11479.1. [Q71RG4-2]
CCDS54134.1. [Q71RG4-1]
RefSeqiNP_001070142.1. NM_001076674.1. [Q71RG4-1]
NP_077012.2. NM_024107.2. [Q71RG4-2]
NP_803190.2. NM_177441.2. [Q71RG4-2]
XP_011523500.1. XM_011525198.1. [Q71RG4-1]
XP_011523503.1. XM_011525201.1. [Q71RG4-1]
XP_011523507.1. XM_011525205.1. [Q71RG4-2]
XP_011523508.1. XM_011525206.1. [Q71RG4-2]
XP_011523509.1. XM_011525207.1. [Q71RG4-2]
XP_011523510.1. XM_011525208.1. [Q71RG4-2]
XP_011523511.1. XM_011525209.1. [Q71RG4-2]
UniGeneiHs.181391.

Genome annotation databases

EnsembliENST00000319511; ENSP00000313214; ENSG00000168591. [Q71RG4-2]
ENST00000357984; ENSP00000350672; ENSG00000168591. [Q71RG4-2]
ENST00000538716; ENSP00000444565; ENSG00000168591. [Q71RG4-1]
ENST00000587172; ENSP00000465153; ENSG00000168591. [Q71RG4-4]
ENST00000587989; ENSP00000466971; ENSG00000168591. [Q71RG4-1]
ENST00000589785; ENSP00000467364; ENSG00000168591. [Q71RG4-2]
ENST00000589856; ENSP00000467960; ENSG00000168591. [Q71RG4-3]
ENST00000590235; ENSP00000465015; ENSG00000168591. [Q71RG4-4]
ENST00000592825; ENSP00000466189; ENSG00000168591. [Q71RG4-4]
GeneIDi79089.
KEGGihsa:79089.
UCSCiuc002ifo.4. human. [Q71RG4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF370373 mRNA. Translation: AAQ15209.1.
AY358780 mRNA. Translation: AAQ89140.1.
AK021759 mRNA. Translation: BAB13886.1.
AK096631 mRNA. Translation: BAG53343.1.
CR622157 mRNA. No translation available.
AL833899 mRNA. Translation: CAD38755.1.
BC001792 mRNA. Translation: AAH01792.1.
BC004306 mRNA. Translation: AAH04306.1.
BC063489 mRNA. Translation: AAH63489.1.
CCDSiCCDS11479.1. [Q71RG4-2]
CCDS54134.1. [Q71RG4-1]
RefSeqiNP_001070142.1. NM_001076674.1. [Q71RG4-1]
NP_077012.2. NM_024107.2. [Q71RG4-2]
NP_803190.2. NM_177441.2. [Q71RG4-2]
XP_011523500.1. XM_011525198.1. [Q71RG4-1]
XP_011523503.1. XM_011525201.1. [Q71RG4-1]
XP_011523507.1. XM_011525205.1. [Q71RG4-2]
XP_011523508.1. XM_011525206.1. [Q71RG4-2]
XP_011523509.1. XM_011525207.1. [Q71RG4-2]
XP_011523510.1. XM_011525208.1. [Q71RG4-2]
XP_011523511.1. XM_011525209.1. [Q71RG4-2]
UniGeneiHs.181391.

3D structure databases

ProteinModelPortaliQ71RG4.
SMRiQ71RG4. Positions 174-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122537. 11 interactions.
DIPiDIP-60896N.
IntActiQ71RG4. 4 interactions.
MINTiMINT-4722595.
STRINGi9606.ENSP00000444565.

PTM databases

iPTMnetiQ71RG4.
PhosphoSiteiQ71RG4.

Polymorphism and mutation databases

BioMutaiTMUB2.
DMDMi110287995.

Proteomic databases

EPDiQ71RG4.
MaxQBiQ71RG4.
PaxDbiQ71RG4.
PRIDEiQ71RG4.

Protocols and materials databases

DNASUi79089.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319511; ENSP00000313214; ENSG00000168591. [Q71RG4-2]
ENST00000357984; ENSP00000350672; ENSG00000168591. [Q71RG4-2]
ENST00000538716; ENSP00000444565; ENSG00000168591. [Q71RG4-1]
ENST00000587172; ENSP00000465153; ENSG00000168591. [Q71RG4-4]
ENST00000587989; ENSP00000466971; ENSG00000168591. [Q71RG4-1]
ENST00000589785; ENSP00000467364; ENSG00000168591. [Q71RG4-2]
ENST00000589856; ENSP00000467960; ENSG00000168591. [Q71RG4-3]
ENST00000590235; ENSP00000465015; ENSG00000168591. [Q71RG4-4]
ENST00000592825; ENSP00000466189; ENSG00000168591. [Q71RG4-4]
GeneIDi79089.
KEGGihsa:79089.
UCSCiuc002ifo.4. human. [Q71RG4-1]

Organism-specific databases

CTDi79089.
GeneCardsiTMUB2.
H-InvDBHIX0013877.
HGNCiHGNC:28459. TMUB2.
HPAiHPA043137.
neXtProtiNX_Q71RG4.
PharmGKBiPA145147917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG1T. Eukaryota.
ENOG4111WH7. LUCA.
GeneTreeiENSGT00390000014069.
HOGENOMiHOG000232067.
HOVERGENiHBG050920.
InParanoidiQ71RG4.
OMAiPVSSQAM.
PhylomeDBiQ71RG4.
TreeFamiTF329265.

Miscellaneous databases

ChiTaRSiTMUB2. human.
GeneWikiiTMUB2.
GenomeRNAii79089.
PROiQ71RG4.

Gene expression databases

BgeeiQ71RG4.
CleanExiHS_TMUB2.
ExpressionAtlasiQ71RG4. baseline and differential.
GenevisibleiQ71RG4. HS.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain and Embryo.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain, Eye and Uterus.

Entry informationi

Entry nameiTMUB2_HUMAN
AccessioniPrimary (citable) accession number: Q71RG4
Secondary accession number(s): B3KU81
, Q8NDI2, Q9BPZ5, Q9HAG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.