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Q71QF9 (PRIC1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Prickle-like protein 1
Alternative name(s):
REST/NRSF-interacting LIM domain protein 1
Gene names
Name:Prickle1
Synonyms:Rilp
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure By similarity. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor By similarity.

Subunit structure

Interacts with REST By similarity.

Subcellular location

Nucleus membrane By similarity. Cytoplasm › cytosol By similarity. Note: A smaller amount is detected in the cytosol By similarity.

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

Sequence caution

The sequence AAQ03034.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 828828Prickle-like protein 1
PRO_0000075890
Propeptide829 – 8313Removed in mature form By similarity
PRO_0000396714

Regions

Domain14 – 122109PET
Domain124 – 18966LIM zinc-binding 1
Domain189 – 24961LIM zinc-binding 2
Domain249 – 31365LIM zinc-binding 3
Compositional bias757 – 7604Poly-Asp
Compositional bias816 – 8216Poly-Lys

Amino acid modifications

Modified residue6811Phosphoserine By similarity
Modified residue8281Cysteine methyl ester By similarity
Lipidation8281S-farnesyl cysteine By similarity

Experimental info

Sequence conflict1151K → I in AW434734. Ref.1
Sequence conflict1211M → T Ref.2
Sequence conflict1251V → L in AW434734. Ref.1
Sequence conflict1331M → I Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q71QF9 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 25B999F11055FBD1

FASTA83194,170
        10         20         30         40         50         60 
MPLEMEPKMS KLAFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 

        70         80         90        100        110        120 
NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 

       130        140        150        160        170        180 
MMHAVCEQCG LQMNGGEVAV FASRAGPGVC WRPSCFVCFT CNELLVDLIY FYQDGKIHCG 

       190        200        210        220        230        240 
RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 

       250        260        270        280        290        300 
GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 

       310        320        330        340        350        360 
YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF 

       370        380        390        400        410        420 
PGLSGSADDT LSRKLDDVSL SGQGAGFAHE EFWKARVDQE ASEDPEEWAE HEDYMTQLLL 

       430        440        450        460        470        480 
KFGDKNLFQQ PPSEVDMRAS EHWIPDNMVT NKPEAKQNHQ SLASKKYQSD MYWAQSQDGL 

       490        500        510        520        530        540 
GDSAYGSHPG PASSRRLQEL DLDHGAAGYN HDQTQWYEDS LECLSDLKPE QSVRDSMDSL 

       550        560        570        580        590        600 
ALSNITGASV DGESKPRPSL YSLQNFEEIE AEDCEKMSNM GTLNSSMLHR SAESLKSLNS 

       610        620        630        640        650        660 
ELCPEKIIPE EKPVHLPVLR RSKSQSRPQQ VKFSDDVIDN GSYDIEIRQP PMSERTRRRV 

       670        680        690        700        710        720 
YHFEERGSRP HHHRHRRSRK SRSDNALNLV TERKYSAKDR LRLYTPDNYE KFIQSKGARE 

       730        740        750        760        770        780 
LQAYMQNANL YGQYAHTTSD YALQNPGMTR FLGLYGDDDD SWCSSSTSSS DSEEEGYFLG 

       790        800        810        820        830 
QPIPQPRPQR FTYYTDDLSS PASALPTPQF NQRTTKSKKK KGHRGKNCII S

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References

[1]Program for rat gene discovery and mapping
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-135.
[2]"REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor."
Shimojo M., Hersh L.B.
Mol. Cell. Biol. 23:9025-9031(2003) [PubMed: 14645515] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 86-831.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AW434734 mRNA. No translation available.
AF399843 mRNA. Translation: AAQ03034.1. Different initiation.
IPIIPI00361687.
UniGeneRn.141040.

3D structure databases

ProteinModelPortalQ71QF9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ71QF9.

PTM databases

PhosphoSiteQ71QF9.

Proteomic databases

PRIDEQ71QF9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD735090. Prickle1.

Phylogenomic databases

eggNOGroNOG13089.
GeneTreeENSGT00550000074438.
HOVERGENHBG053679.
InParanoidQ71QF9.
OrthoDBEOG4FBHS8.

Gene expression databases

ArrayExpressQ71QF9.
GenevestigatorQ71QF9.
GermOnlineENSRNOG00000022772. Rattus norvegicus.

Family and domain databases

InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
Gene3DG3DSA:2.10.110.10. Znf_LIM. 3 hits.
PfamPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRIC1_RAT
AccessionPrimary (citable) accession number: Q71QF9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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