ID   Q71QC9_HUMAN            Unreviewed;        64 AA.
AC   Q71QC9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=KRAB zinc finger protein {ECO:0000313|EMBL:AAQ03245.1};
DE   SubName: Full=Zinc finger protein 331 {ECO:0000313|Ensembl:ENSP00000424929.1};
DE   Flags: Fragment;
GN   Name=ZNF331 {ECO:0000313|EMBL:AAQ03245.1,
GN   ECO:0000313|Ensembl:ENSP00000424929.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAQ03245.1};
RN   [1] {ECO:0000313|EMBL:AAQ03245.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:AAQ03245.1};
RX   PubMed=10502321;
RX   DOI=10.1002/(SICI)1098-2264(199911)26:3<229::AID-GCC7>3.3.CO;2-A;
RA   Rippe V., Belge G., Meiboom M., Kazmierczak B., Fusco A., Bullerdiek J.;
RT   "A KRAB zinc finger protein gene is the potential target of 19q13
RT   translocation in benign thyroid tumors.";
RL   Genes Chromosomes Cancer 26:229-236(1999).
RN   [2] {ECO:0000313|EMBL:AAQ03245.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:AAQ03245.1};
RA   Meiboom M., Gehrken I., Rippe V., Murua Escobar H., Belge G.,
RA   Bullerdiek J.;
RT   "Further molecular characterization of ZNF331 supports its possible role in
RT   the development of thyroid follicular adenomas.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000424929.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4] {ECO:0000313|Ensembl:ENSP00000424929.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC011487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF412398; AAQ03245.1; -; mRNA.
DR   Antibodypedia; 32728; 128 antibodies from 19 providers.
DR   Ensembl; ENST00000505426.1; ENSP00000424929.1; ENSG00000130844.19.
DR   UCSC; uc061ckr.1; human.
DR   HGNC; HGNC:15489; ZNF331.
DR   VEuPathDB; HostDB:ENSG00000130844; -.
DR   GeneTree; ENSGT00940000161267; -.
DR   OMA; LDWMCEG; -.
DR   ChiTaRS; ZNF331; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000130844; Expressed in lower lobe of lung and 207 other cell types or tissues.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR   PANTHER; PTHR23232:SF140; ZINC FINGER PROTEIN 726; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          6..64
FT                   /note="KRAB"
FT                   /evidence="ECO:0000259|PROSITE:PS50805"
FT   NON_TER         64
FT                   /evidence="ECO:0000313|EMBL:AAQ03245.1"
SQ   SEQUENCE   64 AA;  7357 MW;  97D55F245684509E CRC64;
     MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA YENKSLPTEK
     NIHE
//