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Q71MR7

- FPRS7_MOUSE

UniProt

Q71MR7 - FPRS7_MOUSE

Protein

Formyl peptide receptor-related sequence 7

Gene

Fpr-rs7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

    GO - Molecular functioni

    1. N-formyl peptide receptor activity Source: MGI

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formyl peptide receptor-related sequence 7
    Gene namesi
    Name:Fpr-rs7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2448177. Fpr-rs7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Formyl peptide receptor-related sequence 7PRO_0000382026Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed exclusively in vomeronasal organ (PubMed:19387439, PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in heart, liver, lung, spleen smooth muscle and pancreas (PubMed:12459252).3 Publications

    Gene expression databases

    GenevestigatoriQ71MR7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71MR7.
    SMRiQ71MR7. Positions 24-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 6218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 24122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 33837CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8523Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000234122.
    InParanoidiQ71MR7.
    OMAiSANARCY.
    OrthoDBiEOG7PGDQQ.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q71MR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV    50
    AGFRMTHTVT TICYLNLALS DFSYMTSLPF QITSIVMNGE WLFGWFLCKF 100
    VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN LARKVILGSW 150
    ILVLMLIFPH FFFLTTVKDE SGKVHCICNF ESWAATPEEQ VNMSMTVSLI 200
    SVTLSFIVGF SIPMIFIVIC YGLMAAKIGR RGLVNSSRPL RVLTAVAFSF 250
    FVCWFPFQLI FLLGNIGNKE TQNNIDAWVN PASTLASFNS CLNPILYVFL 300
    GQQFRERLIY SLSASLERAL REDSALNSDK IRNLSSQT 338
    Length:338
    Mass (Da):38,141
    Last modified:October 3, 2012 - v2
    Checksum:i4C995F285CCE2577
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti147 – 1471L → F in AAN63621. (PubMed:12459252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF437513 Genomic DNA. Translation: AAN63621.1.
    AC121539 Genomic DNA. No translation available.
    CH466644 Genomic DNA. Translation: EDL38007.1.

    Genome annotation databases

    EnsembliENSMUST00000095637; ENSMUSP00000093297; ENSMUSG00000071276.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A sickly smell - Issue 114 of February 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF437513 Genomic DNA. Translation: AAN63621.1 .
    AC121539 Genomic DNA. No translation available.
    CH466644 Genomic DNA. Translation: EDL38007.1 .

    3D structure databases

    ProteinModelPortali Q71MR7.
    SMRi Q71MR7. Positions 24-305.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095637 ; ENSMUSP00000093297 ; ENSMUSG00000071276 .

    Organism-specific databases

    MGIi MGI:2448177. Fpr-rs7.

    Phylogenomic databases

    eggNOGi NOG150376.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000234122.
    InParanoidi Q71MR7.
    OMAi SANARCY.
    OrthoDBi EOG7PGDQQ.
    TreeFami TF330976.

    Miscellaneous databases

    PROi Q71MR7.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q71MR7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice."
      Wang Z.-G., Ye R.D.
      Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: 129S6/SvEvTac.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
      Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
      Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    5. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPRS7_MOUSE
    AccessioniPrimary (citable) accession number: Q71MR7
    Secondary accession number(s): G3X9N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3