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Protein

Formyl peptide receptor-related sequence 7

Gene

Fpr-rs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 7
Gene namesi
Name:Fpr-rs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2448177. Fpr-rs7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 62CytoplasmicSequence analysisAdd BLAST18
Transmembranei63 – 85Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini86 – 99ExtracellularSequence analysisAdd BLAST14
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 144CytoplasmicSequence analysisAdd BLAST24
Transmembranei145 – 165Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini166 – 198ExtracellularSequence analysisAdd BLAST33
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 241CytoplasmicSequence analysisAdd BLAST22
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 301Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini302 – 338CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003820261 – 338Formyl peptide receptor-related sequence 7Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ71MR7.
PRIDEiQ71MR7.

PTM databases

iPTMnetiQ71MR7.
PhosphoSitePlusiQ71MR7.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal organ (PubMed:19387439, PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in heart, liver, lung, spleen smooth muscle and pancreas (PubMed:12459252).3 Publications

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093297.

Structurei

3D structure databases

ProteinModelPortaliQ71MR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiQ71MR7.
OMAiFANANSC.
OrthoDBiEOG091G0HK2.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71MR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV
60 70 80 90 100
AGFRMTHTVT TICYLNLALS DFSYMTSLPF QITSIVMNGE WLFGWFLCKF
110 120 130 140 150
VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN LARKVILGSW
160 170 180 190 200
ILVLMLIFPH FFFLTTVKDE SGKVHCICNF ESWAATPEEQ VNMSMTVSLI
210 220 230 240 250
SVTLSFIVGF SIPMIFIVIC YGLMAAKIGR RGLVNSSRPL RVLTAVAFSF
260 270 280 290 300
FVCWFPFQLI FLLGNIGNKE TQNNIDAWVN PASTLASFNS CLNPILYVFL
310 320 330
GQQFRERLIY SLSASLERAL REDSALNSDK IRNLSSQT
Length:338
Mass (Da):38,141
Last modified:October 3, 2012 - v2
Checksum:i4C995F285CCE2577
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147L → F in AAN63621 (PubMed:12459252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437513 Genomic DNA. Translation: AAN63621.1.
AC121539 Genomic DNA. No translation available.
CH466644 Genomic DNA. Translation: EDL38007.1.

Genome annotation databases

EnsembliENSMUST00000095637; ENSMUSP00000093297; ENSMUSG00000071276.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF437513 Genomic DNA. Translation: AAN63621.1.
AC121539 Genomic DNA. No translation available.
CH466644 Genomic DNA. Translation: EDL38007.1.

3D structure databases

ProteinModelPortaliQ71MR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093297.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ71MR7.
PhosphoSitePlusiQ71MR7.

Proteomic databases

PaxDbiQ71MR7.
PRIDEiQ71MR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095637; ENSMUSP00000093297; ENSMUSG00000071276.

Organism-specific databases

MGIiMGI:2448177. Fpr-rs7.

Phylogenomic databases

GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiQ71MR7.
OMAiFANANSC.
OrthoDBiEOG091G0HK2.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ71MR7.
SOURCEiSearch...

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRS7_MOUSE
AccessioniPrimary (citable) accession number: Q71MR7
Secondary accession number(s): G3X9N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.