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Q71MR7

- FPRS7_MOUSE

UniProt

Q71MR7 - FPRS7_MOUSE

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Protein

Formyl peptide receptor-related sequence 7

Gene

Fpr-rs7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 7
Gene namesi
Name:Fpr-rs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2448177. Fpr-rs7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Formyl peptide receptor-related sequence 7PRO_0000382026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal organ (PubMed:19387439, PubMed:19497865). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in heart, liver, lung, spleen smooth muscle and pancreas (PubMed:12459252).3 Publications

Gene expression databases

GenevestigatoriQ71MR7.

Structurei

3D structure databases

ProteinModelPortaliQ71MR7.
SMRiQ71MR7. Positions 24-305.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Topological domaini45 – 6218CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini86 – 9914ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 14424CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini166 – 19833ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 24122CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
BLAST
Topological domaini302 – 33837CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei63 – 8523Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiQ71MR7.
OMAiSANARCY.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71MR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV
60 70 80 90 100
AGFRMTHTVT TICYLNLALS DFSYMTSLPF QITSIVMNGE WLFGWFLCKF
110 120 130 140 150
VHMIINVNLF LSIFLITFIA MDRCICVLHP VWAQNHRTVN LARKVILGSW
160 170 180 190 200
ILVLMLIFPH FFFLTTVKDE SGKVHCICNF ESWAATPEEQ VNMSMTVSLI
210 220 230 240 250
SVTLSFIVGF SIPMIFIVIC YGLMAAKIGR RGLVNSSRPL RVLTAVAFSF
260 270 280 290 300
FVCWFPFQLI FLLGNIGNKE TQNNIDAWVN PASTLASFNS CLNPILYVFL
310 320 330
GQQFRERLIY SLSASLERAL REDSALNSDK IRNLSSQT
Length:338
Mass (Da):38,141
Last modified:October 3, 2012 - v2
Checksum:i4C995F285CCE2577
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471L → F in AAN63621. (PubMed:12459252)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF437513 Genomic DNA. Translation: AAN63621.1.
AC121539 Genomic DNA. No translation available.
CH466644 Genomic DNA. Translation: EDL38007.1.

Genome annotation databases

EnsembliENSMUST00000095637; ENSMUSP00000093297; ENSMUSG00000071276.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF437513 Genomic DNA. Translation: AAN63621.1 .
AC121539 Genomic DNA. No translation available.
CH466644 Genomic DNA. Translation: EDL38007.1 .

3D structure databases

ProteinModelPortali Q71MR7.
SMRi Q71MR7. Positions 24-305.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095637 ; ENSMUSP00000093297 ; ENSMUSG00000071276 .

Organism-specific databases

MGIi MGI:2448177. Fpr-rs7.

Phylogenomic databases

eggNOGi NOG150376.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
InParanoidi Q71MR7.
OMAi SANARCY.
OrthoDBi EOG7PGDQQ.
TreeFami TF330976.

Miscellaneous databases

PROi Q71MR7.
SOURCEi Search...

Gene expression databases

Genevestigatori Q71MR7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice."
    Wang Z.-G., Ye R.D.
    Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: 129S6/SvEvTac.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS7_MOUSE
AccessioniPrimary (citable) accession number: Q71MR7
Secondary accession number(s): G3X9N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3