Q71MR7 (FPRS7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl peptide receptor-related sequence 7

Gene names

Name:

Fpr-rs7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed exclusively in vomeronasal organ (Ref.4 and Ref.5). Expressed in 0.8 % of a subset of sensory neurons located in the apical layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed in heart, liver, lung, spleen smooth muscle and pancreas (Ref.1). Ref.1 Ref.4 Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Formyl peptide receptor-related sequence 7		PRO_0000382026
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 62	18	Cytoplasmic Potential
	Transmembrane	63 – 85	23	Helical; Name=2; Potential
	Topological domain	86 – 99	14	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 144	24	Cytoplasmic Potential
	Transmembrane	145 – 165	21	Helical; Name=4; Potential
	Topological domain	166 – 198	33	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Name=5; Potential
	Topological domain	220 – 241	22	Cytoplasmic Potential
	Transmembrane	242 – 262	21	Helical; Name=6; Potential
	Topological domain	263 – 280	18	Extracellular Potential
	Transmembrane	281 – 301	21	Helical; Name=7; Potential
	Topological domain	302 – 338	37	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 178		By similarity
Experimental info
	Sequence conflict	147	1	L → F in AAN63621. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q71MR7 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 4C995F285CCE2577	FASTA	338	38,141
	10 20 30 40 50 60 MEANFSIPQN GSEVVFYDST TSRVICIFLV VVLSITFLLG VIGNGLVIYV AGFRMTHTVT 70 80 90 100 110 120 TICYLNLALS DFSYMTSLPF QITSIVMNGE WLFGWFLCKF VHMIINVNLF LSIFLITFIA 130 140 150 160 170 180 MDRCICVLHP VWAQNHRTVN LARKVILGSW ILVLMLIFPH FFFLTTVKDE SGKVHCICNF 190 200 210 220 230 240 ESWAATPEEQ VNMSMTVSLI SVTLSFIVGF SIPMIFIVIC YGLMAAKIGR RGLVNSSRPL 250 260 270 280 290 300 RVLTAVAFSF FVCWFPFQLI FLLGNIGNKE TQNNIDAWVN PASTLASFNS CLNPILYVFL 310 320 330 GQQFRERLIY SLSASLERAL REDSALNSDK IRNLSSQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice." Wang Z.-G., Ye R.D. Gene 299:57-63(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. Strain: 129S6/SvEvTac.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors." Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I. Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[5]	"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ." Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF437513 Genomic DNA. Translation: AAN63621.1. AC121539 Genomic DNA. No translation available. CH466644 Genomic DNA. Translation: EDL38007.1.
IPI	IPI00379511.
3D structure databases
ProteinModelPortal	Q71MR7.
SMR	Q71MR7. Positions 21-315.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q71MR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000095637; ENSMUSP00000093297; ENSMUSG00000071276.
Organism-specific databases
MGI	MGI:2448177. Fpr-rs7.
Phylogenomic databases
eggNOG	NOG150376.
GeneTree	ENSGT00630000089620.
HOGENOM	HOG000234122.
InParanoid	Q71MR7.
OMA	VILACHA.
OrthoDB	EOG42V8J4.
Gene expression databases
Genevestigator	Q71MR7.
Family and domain databases
InterPro	IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

FPRS7_MOUSE

Accession

Primary (citable) accession number: Q71MR7
Secondary accession number(s): G3X9N8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program