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Protein

Solute carrier organic anion transporter family member 4C1

Gene

Slco4c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.By similarity1 Publication

Kineticsi

  1. KM=8.0 µM for digoxin1 Publication
  2. KM=1.9 µM for thyroxine1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Ion transport, Spermatogenesis, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 4C1
    Alternative name(s):
    Solute carrier family 21 member 20
    Gene namesi
    Name:Slco4c1Imported
    Synonyms:Oatp4c11 Publication, Slc21a20By similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    Proteomesi
    • UP000002494 Componenti: Unplaced

    Organism-specific databases

    RGDi1303048. Slco4c1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 101CytoplasmicSequence analysisAdd BLAST101
    Transmembranei102 – 122Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini123 – 141ExtracellularSequence analysisAdd BLAST19
    Transmembranei142 – 162Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini163 – 168CytoplasmicSequence analysis6
    Transmembranei169 – 193Helical; Name=3Sequence analysisAdd BLAST25
    Topological domaini194 – 218ExtracellularSequence analysisAdd BLAST25
    Transmembranei219 – 249Helical; Name=4Sequence analysisAdd BLAST31
    Topological domaini250 – 269CytoplasmicSequence analysisAdd BLAST20
    Transmembranei270 – 290Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini291 – 306ExtracellularSequence analysisAdd BLAST16
    Transmembranei307 – 331Helical; Name=6Sequence analysisAdd BLAST25
    Topological domaini332 – 376CytoplasmicSequence analysisAdd BLAST45
    Transmembranei377 – 398Helical; Name=7Sequence analysisAdd BLAST22
    Topological domaini399 – 418ExtracellularSequence analysisAdd BLAST20
    Transmembranei419 – 442Helical; Name=8Sequence analysisAdd BLAST24
    Topological domaini443 – 446CytoplasmicSequence analysis4
    Transmembranei447 – 470Helical; Name=9Sequence analysisAdd BLAST24
    Topological domaini471 – 580ExtracellularSequence analysisAdd BLAST110
    Transmembranei581 – 603Helical; Name=10Sequence analysisAdd BLAST23
    Topological domaini604 – 612CytoplasmicSequence analysis9
    Transmembranei613 – 638Helical; Name=11Sequence analysisAdd BLAST26
    Topological domaini639 – 672ExtracellularSequence analysisAdd BLAST34
    Transmembranei673 – 690Helical; Name=12Sequence analysisAdd BLAST18
    Topological domaini691 – 724CytoplasmicSequence analysisAdd BLAST34

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Chemistry databases

    ChEMBLiCHEMBL2073710.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003371541 – 724Solute carrier organic anion transporter family member 4C1Add BLAST724

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei15PhosphoserineCombined sources1
    Modified residuei16PhosphoserineCombined sources1
    Modified residuei19PhosphothreonineBy similarity1
    Modified residuei24PhosphoserineBy similarity1
    Modified residuei26PhosphoserineBy similarity1
    Modified residuei28PhosphoserineBy similarity1
    Disulfide bondi500 ↔ 526PROSITE-ProRule annotation
    Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
    Disulfide bondi506 ↔ 530PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ71MB6.
    PRIDEiQ71MB6.

    PTM databases

    iPTMnetiQ71MB6.
    PhosphoSitePlusiQ71MB6.

    Expressioni

    Tissue specificityi

    Predominantly expressed in kidney and lung but also weakly expressed in brain.1 Publication

    Inductioni

    Expression is significantly decreased in renal failure.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000037089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71MB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini494 – 549Kazal-likePROSITE-ProRule annotationAdd BLAST56

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi692 – 695Poly-ProSequence analysis4

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3626. Eukaryota.
    ENOG410XRSF. LUCA.
    HOGENOMiHOG000231270.
    HOVERGENiHBG100565.
    InParanoidiQ71MB6.
    KOiK14355.
    PhylomeDBiQ71MB6.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q71MB6-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MQGSKGVENP AFVPSSPDTP RRASASPSQV EVSAVASRNQ NGGSQPRESE
    60 70 80 90 100
    DPQKSTEPSP PSSTLPASDE PPGSQLSELE EGPCGWRNFH PQCLQRCNNP
    110 120 130 140 150
    KGFLLHYCLL ALTQGIVVNG LVNISISTIE KRYEMKSSLT GLISSSYDIS
    160 170 180 190 200
    FCVLSLFVSF FGERGHKPRW LAFASFMIGL GALVFSLPHF FSGRYELGTI
    210 220 230 240 250
    FEDTCLTRNS TRCASSTSLL SNYFYVFVLG QLLLGTGGTP LYTLGTAFID
    260 270 280 290 300
    DSVPTHKSSL YIGIGYSMSI LGPAIGYVLG GQLLTMYIDV AMGQSSDLTE
    310 320 330 340 350
    DDPRWLGAWW IGFLLAWLFA WSLIMPFSCF PKHLPGTAKI QAGKTSQTHQ
    360 370 380 390 400
    NNSTSFQHMD ENFGKSIKDF PTAVKNLMRN TVFICLVLST TSEALVTTGF
    410 420 430 440 450
    ATFLPKFIEN QFGLTSSFAA TLGGAVLIPG AALGQILGGV LVSKFKMKCK
    460 470 480 490 500
    NTMKFALCTS GVALMLSFVF IYAKCENGPF AGVSESYNGT GEMGNLTAPC
    510 520 530 540 550
    NANCNCLRSY YYPLCGSDGV QYFSPCFAGC LNSVSNRKPK AYYNCSCIER
    560 570 580 590 600
    KVDITSTAXS PDFEARAGKC KTQCSNLPIF LGIFFITVIF TFMAGTPITV
    610 620 630 640 650
    SILRCVNHRQ RSLALGVQFM LLRLLGTIPG PIIFGVTIDS TCVLWDINEC
    660 670 680 690 700
    GTKGACWIYD NIRMAHMLVA ISVTCKVITI FFNGLAIVLY KPPPPGTEVS
    710 720
    FQSQNVVVST ITVEEDLNKI ENEG
    Length:724
    Mass (Da):78,648
    Last modified:July 5, 2004 - v1
    Checksum:i656E3A02D95A931F
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF454761 mRNA. Translation: AAQ04697.1.
    RefSeqiNP_001002024.1. NM_001002024.1.
    UniGeneiRn.123431.

    Genome annotation databases

    GeneIDi432363.
    KEGGirno:432363.
    UCSCiRGD:1303048. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF454761 mRNA. Translation: AAQ04697.1.
    RefSeqiNP_001002024.1. NM_001002024.1.
    UniGeneiRn.123431.

    3D structure databases

    ProteinModelPortaliQ71MB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000037089.

    Chemistry databases

    ChEMBLiCHEMBL2073710.

    PTM databases

    iPTMnetiQ71MB6.
    PhosphoSitePlusiQ71MB6.

    Proteomic databases

    PaxDbiQ71MB6.
    PRIDEiQ71MB6.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    GeneIDi432363.
    KEGGirno:432363.
    UCSCiRGD:1303048. rat.

    Organism-specific databases

    CTDi353189.
    RGDi1303048. Slco4c1.

    Phylogenomic databases

    eggNOGiKOG3626. Eukaryota.
    ENOG410XRSF. LUCA.
    HOGENOMiHOG000231270.
    HOVERGENiHBG100565.
    InParanoidiQ71MB6.
    KOiK14355.
    PhylomeDBiQ71MB6.

    Miscellaneous databases

    PROiQ71MB6.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 4 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiSO4C1_RAT
    AccessioniPrimary (citable) accession number: Q71MB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 5, 2004
    Last modified: November 2, 2016
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.