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Protein

Xin actin-binding repeat-containing protein 2

Gene

Xirp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protects actin filaments from depolymerization.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xin actin-binding repeat-containing protein 2
Alternative name(s):
Beta-xin
Cardiomyopathy-associated protein 3
L-NAME-induced actin cytoskeletal protein
Gene namesi
Name:Xirp2
Synonyms:Cmya3, Xin2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302980. Xirp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 33023302Xin actin-binding repeat-containing protein 2PRO_0000316989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei565 – 5651PhosphoserineCombined sources
Modified residuei633 – 6331PhosphoserineCombined sources
Modified residuei813 – 8131PhosphoserineBy similarity
Modified residuei1210 – 12101PhosphoserineCombined sources
Modified residuei1573 – 15731PhosphoserineCombined sources
Modified residuei1930 – 19301PhosphothreonineCombined sources
Modified residuei1935 – 19351PhosphoserineCombined sources
Modified residuei2158 – 21581PhosphoserineBy similarity
Modified residuei2198 – 21981PhosphoserineCombined sources
Modified residuei2211 – 22111PhosphoserineCombined sources
Modified residuei2252 – 22521PhosphoserineCombined sources
Modified residuei2987 – 29871PhosphoserineBy similarity
Modified residuei3225 – 32251PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ71LX6.
PRIDEiQ71LX6.

PTM databases

iPTMnetiQ71LX6.
PhosphoSiteiQ71LX6.

Interactioni

Subunit structurei

Interacts with ACTN2. Interacts with F-actin (By similarity).By similarity

Protein-protein interaction databases

BioGridi259825. 1 interaction.
STRINGi10116.ENSRNOP00000048045.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati306 – 32116Xin 1Add
BLAST
Repeati341 – 35616Xin 2Add
BLAST
Repeati381 – 39616Xin 3Add
BLAST
Repeati418 – 43316Xin 4Add
BLAST
Repeati456 – 47116Xin 5Add
BLAST
Repeati496 – 51116Xin 6Add
BLAST
Repeati534 – 54916Xin 7Add
BLAST
Repeati572 – 58716Xin 8Add
BLAST
Repeati606 – 62116Xin 9Add
BLAST
Repeati640 – 65516Xin 10Add
BLAST
Repeati677 – 69216Xin 11Add
BLAST
Repeati713 – 72816Xin 12Add
BLAST
Repeati744 – 75916Xin 13Add
BLAST
Repeati782 – 79716Xin 14Add
BLAST
Repeati820 – 83516Xin 15Add
BLAST
Repeati859 – 87416Xin 16Add
BLAST
Repeati892 – 90716Xin 17Add
BLAST
Repeati930 – 94516Xin 18Add
BLAST
Repeati965 – 98016Xin 19Add
BLAST
Repeati1004 – 101916Xin 20Add
BLAST
Repeati1040 – 105516Xin 21Add
BLAST
Repeati1077 – 109216Xin 22Add
BLAST
Repeati1115 – 113016Xin 23Add
BLAST
Repeati1152 – 116716Xin 24Add
BLAST
Repeati1186 – 120116Xin 25Add
BLAST
Repeati1217 – 123216Xin 26Add
BLAST
Repeati1254 – 126916Xin 27Add
BLAST
Repeati1289 – 130416Xin 28Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2303 – 232826Sequence analysisAdd
BLAST
Coiled coili2696 – 272429Sequence analysisAdd
BLAST
Coiled coili2751 – 277727Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi222 – 2265Poly-Pro
Compositional biasi2052 – 213786Pro-richAdd
BLAST

Domaini

Xin repeats bind F-actin.

Sequence similaritiesi

Belongs to the Xin family.PROSITE-ProRule annotation
Contains 28 Xin repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IF8Z. Eukaryota.
ENOG410ZM11. LUCA.
HOGENOMiHOG000154872.
HOVERGENiHBG108682.
InParanoidiQ71LX6.
PhylomeDBiQ71LX6.

Family and domain databases

InterProiIPR012510. Actin-binding_Xin_repeat.
IPR030072. XIRP1/XIRP2.
IPR030107. XIRP2.
[Graphical view]
PANTHERiPTHR22591. PTHR22591. 1 hit.
PTHR22591:SF1. PTHR22591:SF1. 1 hit.
PfamiPF08043. Xin. 19 hits.
[Graphical view]
PROSITEiPS51389. XIN. 28 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71LX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYQAAVSR GDTRSFSANV MEESDLCTVP GGLAKMKRQF EKDEMTSTCN
60 70 80 90 100
AFSEYQYQHE SRSEQEAIHN RQEIRRNEEE VSKGHRTDVF KAEMMSHLEK
110 120 130 140 150
HTEETNQASQ FRQYVQETVI DTPEDEEIPK VSTKILKEQF EKTAQENFLY
160 170 180 190 200
SDKETTTPAK CIKIENDSEE TLKPSSAMGT SSYTSARQSK ETSTSSYSNH
210 220 230 240 250
SLTSTILAQE KGTPSGKMEE FPPPPPDVFQ TPMDVTAFSQ SPEFPSPPRR
260 270 280 290 300
LPMPRDVYSK QRNLYELNRL YRHIHPELRK NLEKDYISEV SEIVSSHINS
310 320 330 340 350
GNSISAGVQQ ARYVFENTND SSQKDLSSER ENLEWDEILK GEVQSIRWIF
360 370 380 390 400
ENQPLDSINQ GFTDEAYTSK GIADQELIAG GDVKYTTWMF ETQPIDALGV
410 420 430 440 450
PSAGTEENTE KIPELAKGDV CTARWMFETR PLDSMNKMHE WEDETASTFI
460 470 480 490 500
KDITGGDVKT VRYMFETQQL DQLGQLHSVD EMNLLQLRSE LKEIKGNVKR
510 520 530 540 550
SIKCFETQPL YVIRDGSGQM LEIKTVQRED IEKGDVRTAR WMFETQPLDT
560 570 580 590 600
IKQDITEIKV VRGISMEENV KGEVGRARWL FETQPLEKIK EESGEAVLKT
610 620 630 640 650
EAVVGIDVSK KCWMFETQPL DTLKQSPDTE SVSPEERIGG DVKTTKHLLE
660 670 680 690 700
TLPIEALKDS PDVGKLQKIT ASEEEKGDVK HQKWVFETQR LEDIREDKKE
710 720 730 740 750
YTQTVKLEAV DRGHVKNYTH IFESNNLIKV DASHQIEVEG VTRGTVELNK
760 770 780 790 800
SLFETTPLYA IQDHLGKYHQ VKTVQQEEIV RGDVRSCRWL FETRPIDQFD
810 820 830 840 850
ESLHKFQIIR GISAQEIQAG NVKSARWLFE TQPLDSIKYF SNVEETDSKT
860 870 880 890 900
EQSTDIVKGD VKTCKWLFET QPMESLYEKA SLMTNSEDIH KGDVRTCMWL
910 920 930 940 950
FETQPLDAIK NDSEATVKLQ TVKQEEIQGG DVRTACLLFE TENLDNIQGG
960 970 980 990 1000
EGKETKPVEM DIESGDVSGM KYKFENQSLD SISCSSENVL NKIKTLKIED
1010 1020 1030 1040 1050
IQKGNVLNCR WLFENQPIDM IKENQEGDGL VKTVTDIQGG DVRKGCFIFE
1060 1070 1080 1090 1100
TFSLDEIKDE SDVISTRQTN TEEVIKGDVK SYKMLFETQP LYAIQDQEGF
1110 1120 1130 1140 1150
YHEVTTVKKE ETIHGDVRGT RWLFETKPLD SINASEDVYI IKSVTQEDIQ
1160 1170 1180 1190 1200
KGDVSSVRYR FETQPLDMIS DKSHNIMPTI DHIQGGNVQM NKQLFESEGG
1210 1220 1230 1240 1250
DKKNYVRTVS INEIQKGNVK TSTWLFETHS IDELGEVSTY ENIKTVTQED
1260 1270 1280 1290 1300
VQKGDVKQAV WLFENQTLDS IKELDESDTK ITKEEIPPSD VKTTTWLFET
1310 1320 1330 1340 1350
TPIHEFNETR IEKEEIIGKS IKETLEDLYS QRVVEAPGII IEADEVGDVR
1360 1370 1380 1390 1400
MAKYKLMNQR TPEIQKEEVI RADLGNIMMN LLSQRDCTKK EIFISEEEKG
1410 1420 1430 1440 1450
NVNFTKTQLL NRSMEFHAEK EEIVRGDVKQ AIQKLFSEER CAKRGILIQE
1460 1470 1480 1490 1500
DEKGDVNMTI YCLLHENAGD KTKREDILGG DVRRTIHNLL SSASNDKISE
1510 1520 1530 1540 1550
RTKIDASERG NVQFFTTCIE TGALDYLKQL QTGSNETLTA RKQEGEEEII
1560 1570 1580 1590 1600
GGDVEGTKFL LKKRQSSIER TVSETDIIPG DVRNTVKVFM TEPQSASFKT
1610 1620 1630 1640 1650
AKEEIVKGDL KSTLNSLNQA MNQKVVAKTE DIMKDDKAAI LKSLKESGGR
1660 1670 1680 1690 1700
QKEHKQSASI SSDIGQAIEC LEKATNTRTE ILKKELILDD LKTSLRSLKE
1710 1720 1730 1740 1750
EQYSFKEVGK QGMVKDVLGF SERQELGIHP AAVQREKKSL LQPVPGPCEP
1760 1770 1780 1790 1800
AIRQQAGPGP LDEATQKSCH RSLTEERTEA NLPKAPKGTV KIVIDREQNN
1810 1820 1830 1840 1850
DALEKSLRKM SNSEHRAMKN VLDMGDRRGV WTESKECLCS DDHMSKYVSA
1860 1870 1880 1890 1900
SMSRKKSLKT KESENVRESK DDVSSTQSVD KTFRKQQTQN CELGKDHQKS
1910 1920 1930 1940 1950
QFQDSYAKNQ KNTQNISMSA ETQSYRPDPT QHPVSNPAGE TLEMTRDFQK
1960 1970 1980 1990 2000
QALIRQEKQN SNKDMRKNDM GLQPLPVGKD AHSAPGVTVS GKNHKRTQAP
2010 2020 2030 2040 2050
DKKQRIDVCL ESQDFLMKTN TSKELKMAME RSFNPVNLYP DCGVKENEDA
2060 2070 2080 2090 2100
LPPPSPPPPP PSNASSEIEF PLPPPPPIML LPEKNEFPPS SPTEKSRAEL
2110 2120 2130 2140 2150
ESLPTLPLPP PPGDEKSDQE CLPTSLPPPP PTAPSQPAHL LSSSVLEHHS
2160 2170 2180 2190 2200
EAFLQQYSRK ETLDSHQLHS QAKILTGKSP PPTLPKPKLP ERIKAKMSQD
2210 2220 2230 2240 2250
SPSGELERSL SDVEIKTTLS KDQKSSLVAE SREHTEAKQE VFRKSLGRKQ
2260 2270 2280 2290 2300
LSISSANSLS QTVPEIPAPK EKQTAPLVKS HSFPSGSEQQ SPKPYMRKFK
2310 2320 2330 2340 2350
TPLMIAEEKY RQQREELEKQ RRESSCHSII KTETQHRSLS EKEKETELQK
2360 2370 2380 2390 2400
AAEAMSTPRK DSDFTRAQPN LEPKSKAVIA SECSESQLST ASALTVATER
2410 2420 2430 2440 2450
LQHVLAASDD KLTLRREGTQ NSSDTLQSKT ACEINQSHKE CRTEQTFEQH
2460 2470 2480 2490 2500
VEKLPFPQTK PISPSFKVKT IRLPALDHTL TETDLSSERR VKQSEIDVQT
2510 2520 2530 2540 2550
STKEMNKEIK KTEVSTQCDN KQSVAEKYFQ LPKTEKRVTV QMPKDYAAKS
2560 2570 2580 2590 2600
HQSKLQTVPK KHGGLGEFDR GNVLGREGKN QDSSMSSTKE SRVIVERKQE
2610 2620 2630 2640 2650
HLQDQSVPRL VQQKIIGESL DSRVQNFQQT QTQTSRIEHK ELSQPYSEKK
2660 2670 2680 2690 2700
CLRDKDKQQK QVSSNTDDSK QEITQKQSSF SSVRESQQDG EKCAINILEF
2710 2720 2730 2740 2750
LRKREELQQI LSRVKQFEAD SNKSGLKTFQ TLLNIAPVWL ISEEKREYGV
2760 2770 2780 2790 2800
RVAMENNLEK VKEEIIHIKT QAEEMLVHCE HVIRTAMMAS QTGKQKDKPT
2810 2820 2830 2840 2850
NLNEMPLKVS NVNLSSHKGT EQKESKIVEE KLASRQVATH SEAATHNPAK
2860 2870 2880 2890 2900
TYQEAKGDDS KMAPPSLKTR PPSPTFITIE STARRAETST KSELSQSPKN
2910 2920 2930 2940 2950
NSCVEPLPRR PMEHTSRLPR TSTSPSPPRS RSEQLVRLKD TTARLAKGTI
2960 2970 2980 2990 3000
PCSPGTPVPV VEKRSEVVMS PATLRRQIKI ESRGGDSPPT ITIPVSVNHH
3010 3020 3030 3040 3050
VVSGSFRESV DAQEAVKKTE KTETYVHKDK KNSVSSAMPE TESYDAVEII
3060 3070 3080 3090 3100
RKVEGPHLSE HRERFEATNQ TVQMAEHFLN GHENEVNRWF REFENGPVFG
3110 3120 3130 3140 3150
AKTERRAYAN GEINHNMKQE SHTFCKEEFG LESSETANFT GFSYRHPREH
3160 3170 3180 3190 3200
RAKAPATQPR VHSEARALNE HFLSVDAFDS QIVESQVATS SSRSSEAGRS
3210 3220 3230 3240 3250
GFDFKHAPPT YEDVIAGHIL DIADSPTNLR RNFQKTWQES ERVFKSVGYE
3260 3270 3280 3290 3300
TSDAHATEMS RAFQEELAFL SETVGPRQGN LHNLSKDGLS NGVPRSRPAE

FS
Length:3,302
Mass (Da):373,982
Last modified:July 5, 2004 - v1
Checksum:i65EFEFEED1778ECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466694 mRNA. Translation: AAQ05020.1.
RefSeqiNP_973718.1. NM_201989.1.
UniGeneiRn.145414.

Genome annotation databases

GeneIDi311098.
KEGGirno:311098.
UCSCiRGD:1302980. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466694 mRNA. Translation: AAQ05020.1.
RefSeqiNP_973718.1. NM_201989.1.
UniGeneiRn.145414.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi259825. 1 interaction.
STRINGi10116.ENSRNOP00000048045.

PTM databases

iPTMnetiQ71LX6.
PhosphoSiteiQ71LX6.

Proteomic databases

PaxDbiQ71LX6.
PRIDEiQ71LX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi311098.
KEGGirno:311098.
UCSCiRGD:1302980. rat.

Organism-specific databases

CTDi129446.
RGDi1302980. Xirp2.

Phylogenomic databases

eggNOGiENOG410IF8Z. Eukaryota.
ENOG410ZM11. LUCA.
HOGENOMiHOG000154872.
HOVERGENiHBG108682.
InParanoidiQ71LX6.
PhylomeDBiQ71LX6.

Miscellaneous databases

PROiQ71LX6.

Family and domain databases

InterProiIPR012510. Actin-binding_Xin_repeat.
IPR030072. XIRP1/XIRP2.
IPR030107. XIRP2.
[Graphical view]
PANTHERiPTHR22591. PTHR22591. 1 hit.
PTHR22591:SF1. PTHR22591:SF1. 1 hit.
PfamiPF08043. Xin. 19 hits.
[Graphical view]
PROSITEiPS51389. XIN. 28 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene involved in the pathogenesis of cardiac hypertrophy in rats."
    Inoue S., Egashira K., Koike G., Takeshita A.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar Kyoto.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1930 AND SER-1935, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565; SER-633; SER-1210; SER-1573; SER-2198; SER-2211; SER-2252 AND SER-3225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXIRP2_RAT
AccessioniPrimary (citable) accession number: Q71LX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.