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Q71LX4

- TLN2_MOUSE

UniProt

Q71LX4 - TLN2_MOUSE

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Protein
Talin-2
Gene
Tln2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity By similarity.

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. cytoskeletal anchoring at plasma membrane Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Talin-2
Gene namesi
Name:Tln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1917799. Tln2.

Subcellular locationi

Cell junctionfocal adhesion By similarity. Cell junctionsynapse By similarity. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity
Note: Focal adhesion plaques and synapses By similarity.

GO - Cellular componenti

  1. actin cytoskeleton Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. fascia adherens Source: MGI
  4. focal adhesion Source: UniProtKB-SubCell
  5. plasma membrane Source: UniProtKB-SubCell
  6. ruffle Source: InterPro
  7. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23752375Talin-2
PRO_0000219432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1666 – 16661Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ71LX4.
PaxDbiQ71LX4.
PRIDEiQ71LX4.

Expressioni

Gene expression databases

CleanExiMM_TLN2.
GenevestigatoriQ71LX4.

Interactioni

Subunit structurei

Interacts directly with PIP5K1C By similarity.

Protein-protein interaction databases

DIPiDIP-53098N.
IntActiQ71LX4. 1 interaction.
MINTiMINT-4997511.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi211 – 22616
Helixi234 – 24916
Turni254 – 2563
Helixi264 – 2663
Helixi270 – 2723
Helixi278 – 28811
Turni289 – 2913
Helixi294 – 30714
Turni309 – 3124
Beta strandi314 – 3218
Beta strandi328 – 3358
Beta strandi337 – 3437
Turni345 – 3473
Beta strandi350 – 3556
Helixi356 – 3583
Beta strandi361 – 3655
Beta strandi368 – 3725
Helixi374 – 3763
Beta strandi381 – 3844
Helixi388 – 40720

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3G9WX-ray2.16A/B198-408[»]
ProteinModelPortaliQ71LX4.
SMRiQ71LX4. Positions 1-408, 489-915, 917-1047, 1209-1360, 1362-1794, 1887-2203, 2208-2375.

Miscellaneous databases

EvolutionaryTraceiQ71LX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 406319FERM
Add
BLAST
Domaini2205 – 2375171I/LWEQ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 40695Interaction with PIP5K1C By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi862 – 94382Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 1 FERM domain.
Contains 1 I/LWEQ domain.

Phylogenomic databases

eggNOGiNOG324465.
HOGENOMiHOG000006734.
HOVERGENiHBG023870.
KOiK06271.

Family and domain databases

Gene3Di1.20.1410.10. 4 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR002404. Insln_rcpt_S1.
IPR011993. PH_like_dom.
IPR015711. Talin-2.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR19981:SF15. PTHR19981:SF15. 1 hit.
PfamiPF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 1 hit.
PF02174. IRS. 1 hit.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 2 hits.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00295. B41. 1 hit.
[Graphical view]
SUPFAMiSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 5 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 4 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71LX4-1 [UniParc]FASTAAdd to Basket

« Hide

MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG     50
LFLSDEDPRK GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK 100
TVMVDDSKTV GELLVTICSR IGITNYEEYS LIQETIEEKK EEGTGTLKKD 150
RTLLRDERKM EKLKAKLHTD DDLNWLDHSR TFREQGVDEN ETLLLRRKFF 200
YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF GGFQAQIQFG 250
PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK 300
YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV 350
LQEWPLTTVK RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID 400
IILKKKQSKD RFGLEGDEES TMLEESVSPK KRSTILQQQF NRTGKAEHGS 450
VALPAVMRSG SSGPETFNVG SMPSPQQQVM VGQMHRGHMP PLTSAQQALM 500
GTINTSMHAV QQAQDDLSEL DSLPPLGQDM ASRVWVQNKV DESKHEIHSQ 550
VDAITAGTAS VVNLTAGDPA DTDYTAVGCA ITTISSNLTE MSKGVKLLAA 600
LMDDDVGSGE DLLRAARTLA GAVSDLLKAV QPTSGEPRQT VLTAAGSIGQ 650
ASGDLLRQIG ENETDERFQD VLMSLAKAVA NAAAMLVLKA KNVAQVAEDT 700
VLQNRVIAAA TQCALSTSQL VACAKVVSPT ISSPVCQEQL IEAGKLVDRS 750
VENCVRACQA ATSDSELLKQ VSAAASVVSQ ALHDLLQHVR QFASRGEPIG 800
RYDQATDTIM CVTESIFSSM GDAGEMVRQA RVLAQATSDL VNAMRSDAEA 850
EIDMENSKKL LAAAKLLADS TARMVEAAKG AAANPENEDQ QQRLREAAEG 900
LRVATNAAAQ NAIKKKIVNR LEVAAKQAAA AATQTIAASQ NAAISNKNPS 950
AQQQLVQSCK AVADHIPQLV QGVRGSQAQA EDLSAQLALI ISSQNFLQPG 1000
SKMVSSAKAA VPTVSDQAAA MQLSQCAKNL ATSLAELRTA SQKAHEACGP 1050
MEIDSALNTV QTLKNELQDA KMAAAESQLK PLPGETLEKC AQDLGSTSKG 1100
VGSSMAQLLT CAAQGNEHYT GVAARETAQA LKTLAQAARG VAASTNDPEA 1150
AHAMLDSARD VMEGSAMLIQ EAKQALIAPG DTESQQRLAQ VAKAVSHSLN 1200
NCVNCLPGQK DVDVALKSIG EASKKLLVDS LPPSTKPFQE AQSELNQAAA 1250
DLNQSAGEVV HATRGQSGEL AAASGKFSDD FDEFLDAGIE MAGQAQTKED 1300
QMQVIGNLKN ISMASSKLLL AAKSLSVDPG APNAKNLLAA AARAVTESIN 1350
QLIMLCTQQA PGQKECDNAL RELETVKGML ENPNEPVSDL SYFDCIESVM 1400
ENSKVLGESM AGISQNAKTG DLPAFGECVG IASKALCGLT EAAAQAAYLV 1450
GISDPNSQAG HQGLVDPIQF ARANQAIQMA CQNLVDPGSS PSQVLSAATI 1500
VAKHTSALCN ACRIASSKTA NPVAKRHFVQ SAKEVANSTA NLVKTIKALD 1550
GDFSEDNRNK CRIATTPLIE AVENLTAFAS NPEFASIPAQ ISSEGSQAQE 1600
PILVSAKTML ESSSYLIRTA RSLAINPKDP PTWSVLAGHS HTVSDSIKSL 1650
ITSIRDKAPG QRECDYSIDG INRCIRDIEQ ASLAAVSQSL ATRDDISVEA 1700
LQEQLTSVVQ EIGHLIDPIA TAARGEAAQL GHKVTQLASY FEPLILAAVG 1750
VASKMLDHQQ QMTVLDQTKT LAESALQMLY AAKEGGGNPK AVHTAPEPKG 1800
TFVDYQTTVV KYSKAIAVTA QEMIGFQIRT RVQDLGHGCI FLVQKAGALQ 1850
VCPTDSYTKR ELIECARSVT EKVSLVLSAL QAGNKGTQAC ITAATAVSGI 1900
IADLDTTIMF ATAGTLNAEN GETFADHREN ILKTAKALVE DTKLLVSGAA 1950
STPDKLAQAA QSSAATITQL AEVVKLGAAS LGSNDPETQV VLINAIKDVA 2000
KALSDLIGAT KGAASKPADD PSMYQLKGAA KVMVTNVTSL LKTVKAVEDE 2050
ATRGTRALEA TIEYIKQELT VFQSKDIPEK TSSPEESIRM TKGITMATAK 2100
AVAAGNSCRQ EDVIATANLS RKAVSDMLIA CKQASFYPDV SEEVRTRALR 2150
YGTECTLGYL DLLEHVLVIL QKPTPELKHQ LAAFSKRVAG AVTELIQAAE 2200
AMKGTEWVDP EDPTVIAETE LLGAAASIEA AAKKLEQLKP RAKPKQADET 2250
LDFEEQILEA AKSIAAATSA LVKSASAAQR ELVAQGKVGS IPANAADDGQ 2300
WSQGLISAAR MVAAATSSLC EAANASVQGH ASEEKLISSA KQVAASTAQL 2350
LVACKVKADQ DSEAMKRLQA AGNAV 2375
Length:2,375
Mass (Da):253,621
Last modified:July 27, 2011 - v3
Checksum:i2264EEEC374476FC
GO

Sequence cautioni

The sequence AAQ05019.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAC34927.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021V → K in BAC34927. 1 Publication
Sequence conflicti432 – 4321R → Q in AAQ05019. 1 Publication
Sequence conflicti447 – 4471E → K in AAQ05019. 1 Publication
Sequence conflicti1003 – 10031M → V in AAQ05019. 1 Publication
Sequence conflicti1030 – 10301L → P in AAQ05019. 1 Publication
Sequence conflicti1755 – 17551M → I in AAQ05019. 1 Publication
Sequence conflicti1775 – 17751A → V in AAQ05019. 1 Publication
Sequence conflicti1792 – 17921V → Q in AAQ05019. 1 Publication
Sequence conflicti1795 – 17951A → S in AAQ05019. 1 Publication
Sequence conflicti1816 – 18161I → V in AAQ05019. 1 Publication
Sequence conflicti2047 – 20471V → A in AAQ05019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107740 Genomic DNA. No translation available.
AC107755 Genomic DNA. No translation available.
AC173343 Genomic DNA. No translation available.
AF467081 mRNA. Translation: AAQ05019.1. Different initiation.
AK052301 mRNA. Translation: BAC34927.1. Different initiation.
RefSeqiNP_001074711.2. NM_001081242.2.
UniGeneiMm.33645.

Genome annotation databases

GeneIDi70549.
KEGGimmu:70549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107740 Genomic DNA. No translation available.
AC107755 Genomic DNA. No translation available.
AC173343 Genomic DNA. No translation available.
AF467081 mRNA. Translation: AAQ05019.1 . Different initiation.
AK052301 mRNA. Translation: BAC34927.1 . Different initiation.
RefSeqi NP_001074711.2. NM_001081242.2.
UniGenei Mm.33645.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3G9W X-ray 2.16 A/B 198-408 [» ]
ProteinModelPortali Q71LX4.
SMRi Q71LX4. Positions 1-408, 489-915, 917-1047, 1209-1360, 1362-1794, 1887-2203, 2208-2375.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-53098N.
IntActi Q71LX4. 1 interaction.
MINTi MINT-4997511.

Proteomic databases

MaxQBi Q71LX4.
PaxDbi Q71LX4.
PRIDEi Q71LX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 70549.
KEGGi mmu:70549.

Organism-specific databases

CTDi 83660.
MGIi MGI:1917799. Tln2.

Phylogenomic databases

eggNOGi NOG324465.
HOGENOMi HOG000006734.
HOVERGENi HBG023870.
KOi K06271.

Miscellaneous databases

EvolutionaryTracei Q71LX4.
NextBioi 331831.
PROi Q71LX4.
SOURCEi Search...

Gene expression databases

CleanExi MM_TLN2.
Genevestigatori Q71LX4.

Family and domain databases

Gene3Di 1.20.1410.10. 4 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR002404. Insln_rcpt_S1.
IPR011993. PH_like_dom.
IPR015711. Talin-2.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view ]
PANTHERi PTHR19981:SF15. PTHR19981:SF15. 1 hit.
Pfami PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 1 hit.
PF02174. IRS. 1 hit.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 2 hits.
[Graphical view ]
ProDomi PD011820. ILWEQ. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00295. B41. 1 hit.
[Graphical view ]
SUPFAMi SSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 5 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 4 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-135.
    Strain: C57BL/6J.
    Tissue: Embryonic heart.
  3. "Expression of the newly identified Mus musculus talin 2 gene."
    Dubois A., Albiges-Rizo C., Block M., Faessler R.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-2375.
    Tissue: Kidney.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1666, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiTLN2_MOUSE
AccessioniPrimary (citable) accession number: Q71LX4
Secondary accession number(s): E9QM49, Q8BWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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