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Protein

Talin-2

Gene

Tln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Talin-2
Gene namesi
Name:Tln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917799. Tln2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell junctionfocal adhesion By similarity
  • Cell junctionsynapse By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Focal adhesion plaques and synapses.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • cytoskeleton Source: UniProtKB-SubCell
  • fascia adherens Source: MGI
  • focal adhesion Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • ruffle Source: InterPro
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194321 – 2375Talin-2Add BLAST2375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei428PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei1024PhosphoserineBy similarity1
Modified residuei1666PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ71LX4.
MaxQBiQ71LX4.
PaxDbiQ71LX4.
PeptideAtlasiQ71LX4.
PRIDEiQ71LX4.

PTM databases

iPTMnetiQ71LX4.
PhosphoSitePlusiQ71LX4.
SwissPalmiQ71LX4.

Expressioni

Gene expression databases

CleanExiMM_TLN2.

Interactioni

Subunit structurei

Interacts directly with PIP5K1C.By similarity

Protein-protein interaction databases

DIPiDIP-53098N.
IntActiQ71LX4. 1 interactor.
MINTiMINT-4997511.
STRINGi10090.ENSMUSP00000035272.

Structurei

Secondary structure

12375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi211 – 226Combined sources16
Helixi234 – 249Combined sources16
Turni254 – 256Combined sources3
Helixi264 – 266Combined sources3
Helixi270 – 272Combined sources3
Helixi278 – 288Combined sources11
Turni289 – 291Combined sources3
Helixi294 – 307Combined sources14
Turni309 – 312Combined sources4
Beta strandi314 – 321Combined sources8
Beta strandi328 – 335Combined sources8
Beta strandi337 – 343Combined sources7
Turni345 – 347Combined sources3
Beta strandi350 – 355Combined sources6
Helixi356 – 358Combined sources3
Beta strandi361 – 365Combined sources5
Beta strandi368 – 372Combined sources5
Helixi374 – 376Combined sources3
Beta strandi381 – 384Combined sources4
Helixi388 – 407Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9WX-ray2.16A/B198-408[»]
ProteinModelPortaliQ71LX4.
SMRiQ71LX4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ71LX4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 406FERMPROSITE-ProRule annotationAdd BLAST319
Domaini2205 – 2375I/LWEQPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 406Interaction with PIP5K1CBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi862 – 943Ala-richAdd BLAST82

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 I/LWEQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4261. Eukaryota.
ENOG410XQ0V. LUCA.
HOGENOMiHOG000006734.
HOVERGENiHBG023870.
InParanoidiQ71LX4.
KOiK06271.

Family and domain databases

Gene3Di1.20.1410.10. 4 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR032425. FERM_f0.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR011993. PH_dom-like.
IPR015711. Talin-2.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR19981:SF15. PTHR19981:SF15. 1 hit.
PfamiPF16511. FERM_f0. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 2 hits.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 2 hits.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00295. B41. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 5 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 4 hits.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71LX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG
60 70 80 90 100
LFLSDEDPRK GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK
110 120 130 140 150
TVMVDDSKTV GELLVTICSR IGITNYEEYS LIQETIEEKK EEGTGTLKKD
160 170 180 190 200
RTLLRDERKM EKLKAKLHTD DDLNWLDHSR TFREQGVDEN ETLLLRRKFF
210 220 230 240 250
YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF GGFQAQIQFG
260 270 280 290 300
PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMSEIEAKVK
310 320 330 340 350
YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV
360 370 380 390 400
LQEWPLTTVK RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID
410 420 430 440 450
IILKKKQSKD RFGLEGDEES TMLEESVSPK KRSTILQQQF NRTGKAEHGS
460 470 480 490 500
VALPAVMRSG SSGPETFNVG SMPSPQQQVM VGQMHRGHMP PLTSAQQALM
510 520 530 540 550
GTINTSMHAV QQAQDDLSEL DSLPPLGQDM ASRVWVQNKV DESKHEIHSQ
560 570 580 590 600
VDAITAGTAS VVNLTAGDPA DTDYTAVGCA ITTISSNLTE MSKGVKLLAA
610 620 630 640 650
LMDDDVGSGE DLLRAARTLA GAVSDLLKAV QPTSGEPRQT VLTAAGSIGQ
660 670 680 690 700
ASGDLLRQIG ENETDERFQD VLMSLAKAVA NAAAMLVLKA KNVAQVAEDT
710 720 730 740 750
VLQNRVIAAA TQCALSTSQL VACAKVVSPT ISSPVCQEQL IEAGKLVDRS
760 770 780 790 800
VENCVRACQA ATSDSELLKQ VSAAASVVSQ ALHDLLQHVR QFASRGEPIG
810 820 830 840 850
RYDQATDTIM CVTESIFSSM GDAGEMVRQA RVLAQATSDL VNAMRSDAEA
860 870 880 890 900
EIDMENSKKL LAAAKLLADS TARMVEAAKG AAANPENEDQ QQRLREAAEG
910 920 930 940 950
LRVATNAAAQ NAIKKKIVNR LEVAAKQAAA AATQTIAASQ NAAISNKNPS
960 970 980 990 1000
AQQQLVQSCK AVADHIPQLV QGVRGSQAQA EDLSAQLALI ISSQNFLQPG
1010 1020 1030 1040 1050
SKMVSSAKAA VPTVSDQAAA MQLSQCAKNL ATSLAELRTA SQKAHEACGP
1060 1070 1080 1090 1100
MEIDSALNTV QTLKNELQDA KMAAAESQLK PLPGETLEKC AQDLGSTSKG
1110 1120 1130 1140 1150
VGSSMAQLLT CAAQGNEHYT GVAARETAQA LKTLAQAARG VAASTNDPEA
1160 1170 1180 1190 1200
AHAMLDSARD VMEGSAMLIQ EAKQALIAPG DTESQQRLAQ VAKAVSHSLN
1210 1220 1230 1240 1250
NCVNCLPGQK DVDVALKSIG EASKKLLVDS LPPSTKPFQE AQSELNQAAA
1260 1270 1280 1290 1300
DLNQSAGEVV HATRGQSGEL AAASGKFSDD FDEFLDAGIE MAGQAQTKED
1310 1320 1330 1340 1350
QMQVIGNLKN ISMASSKLLL AAKSLSVDPG APNAKNLLAA AARAVTESIN
1360 1370 1380 1390 1400
QLIMLCTQQA PGQKECDNAL RELETVKGML ENPNEPVSDL SYFDCIESVM
1410 1420 1430 1440 1450
ENSKVLGESM AGISQNAKTG DLPAFGECVG IASKALCGLT EAAAQAAYLV
1460 1470 1480 1490 1500
GISDPNSQAG HQGLVDPIQF ARANQAIQMA CQNLVDPGSS PSQVLSAATI
1510 1520 1530 1540 1550
VAKHTSALCN ACRIASSKTA NPVAKRHFVQ SAKEVANSTA NLVKTIKALD
1560 1570 1580 1590 1600
GDFSEDNRNK CRIATTPLIE AVENLTAFAS NPEFASIPAQ ISSEGSQAQE
1610 1620 1630 1640 1650
PILVSAKTML ESSSYLIRTA RSLAINPKDP PTWSVLAGHS HTVSDSIKSL
1660 1670 1680 1690 1700
ITSIRDKAPG QRECDYSIDG INRCIRDIEQ ASLAAVSQSL ATRDDISVEA
1710 1720 1730 1740 1750
LQEQLTSVVQ EIGHLIDPIA TAARGEAAQL GHKVTQLASY FEPLILAAVG
1760 1770 1780 1790 1800
VASKMLDHQQ QMTVLDQTKT LAESALQMLY AAKEGGGNPK AVHTAPEPKG
1810 1820 1830 1840 1850
TFVDYQTTVV KYSKAIAVTA QEMIGFQIRT RVQDLGHGCI FLVQKAGALQ
1860 1870 1880 1890 1900
VCPTDSYTKR ELIECARSVT EKVSLVLSAL QAGNKGTQAC ITAATAVSGI
1910 1920 1930 1940 1950
IADLDTTIMF ATAGTLNAEN GETFADHREN ILKTAKALVE DTKLLVSGAA
1960 1970 1980 1990 2000
STPDKLAQAA QSSAATITQL AEVVKLGAAS LGSNDPETQV VLINAIKDVA
2010 2020 2030 2040 2050
KALSDLIGAT KGAASKPADD PSMYQLKGAA KVMVTNVTSL LKTVKAVEDE
2060 2070 2080 2090 2100
ATRGTRALEA TIEYIKQELT VFQSKDIPEK TSSPEESIRM TKGITMATAK
2110 2120 2130 2140 2150
AVAAGNSCRQ EDVIATANLS RKAVSDMLIA CKQASFYPDV SEEVRTRALR
2160 2170 2180 2190 2200
YGTECTLGYL DLLEHVLVIL QKPTPELKHQ LAAFSKRVAG AVTELIQAAE
2210 2220 2230 2240 2250
AMKGTEWVDP EDPTVIAETE LLGAAASIEA AAKKLEQLKP RAKPKQADET
2260 2270 2280 2290 2300
LDFEEQILEA AKSIAAATSA LVKSASAAQR ELVAQGKVGS IPANAADDGQ
2310 2320 2330 2340 2350
WSQGLISAAR MVAAATSSLC EAANASVQGH ASEEKLISSA KQVAASTAQL
2360 2370
LVACKVKADQ DSEAMKRLQA AGNAV
Length:2,375
Mass (Da):253,621
Last modified:July 27, 2011 - v3
Checksum:i2264EEEC374476FC
GO

Sequence cautioni

The sequence AAQ05019 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC34927 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102V → K in BAC34927 (PubMed:16141072).Curated1
Sequence conflicti432R → Q in AAQ05019 (Ref. 3) Curated1
Sequence conflicti447E → K in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1003M → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1030L → P in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1755M → I in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1775A → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1792V → Q in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1795A → S in AAQ05019 (Ref. 3) Curated1
Sequence conflicti1816I → V in AAQ05019 (Ref. 3) Curated1
Sequence conflicti2047V → A in AAQ05019 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107740 Genomic DNA. No translation available.
AC107755 Genomic DNA. No translation available.
AC173343 Genomic DNA. No translation available.
AF467081 mRNA. Translation: AAQ05019.1. Different initiation.
AK052301 mRNA. Translation: BAC34927.1. Different initiation.
RefSeqiNP_001074711.2. NM_001081242.2.
UniGeneiMm.33645.

Genome annotation databases

GeneIDi70549.
KEGGimmu:70549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107740 Genomic DNA. No translation available.
AC107755 Genomic DNA. No translation available.
AC173343 Genomic DNA. No translation available.
AF467081 mRNA. Translation: AAQ05019.1. Different initiation.
AK052301 mRNA. Translation: BAC34927.1. Different initiation.
RefSeqiNP_001074711.2. NM_001081242.2.
UniGeneiMm.33645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3G9WX-ray2.16A/B198-408[»]
ProteinModelPortaliQ71LX4.
SMRiQ71LX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-53098N.
IntActiQ71LX4. 1 interactor.
MINTiMINT-4997511.
STRINGi10090.ENSMUSP00000035272.

PTM databases

iPTMnetiQ71LX4.
PhosphoSitePlusiQ71LX4.
SwissPalmiQ71LX4.

Proteomic databases

EPDiQ71LX4.
MaxQBiQ71LX4.
PaxDbiQ71LX4.
PeptideAtlasiQ71LX4.
PRIDEiQ71LX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70549.
KEGGimmu:70549.

Organism-specific databases

CTDi83660.
MGIiMGI:1917799. Tln2.

Phylogenomic databases

eggNOGiKOG4261. Eukaryota.
ENOG410XQ0V. LUCA.
HOGENOMiHOG000006734.
HOVERGENiHBG023870.
InParanoidiQ71LX4.
KOiK06271.

Miscellaneous databases

ChiTaRSiTln2. mouse.
EvolutionaryTraceiQ71LX4.
PROiQ71LX4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TLN2.

Family and domain databases

Gene3Di1.20.1410.10. 4 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR032425. FERM_f0.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR011993. PH_dom-like.
IPR015711. Talin-2.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR19981:SF15. PTHR19981:SF15. 1 hit.
PfamiPF16511. FERM_f0. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 2 hits.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 2 hits.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00295. B41. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 5 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 4 hits.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLN2_MOUSE
AccessioniPrimary (citable) accession number: Q71LX4
Secondary accession number(s): E9QM49, Q8BWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.