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Q71HN5 (PYRF_RHIOR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
OrganismRhizopus oryzae (Mucormycosis agent) (Rhizopus arrhizus var. delemar)
Taxonomic identifier64495 [NCBI]
Taxonomic lineageEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134677

Regions

Region60 – 623Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site381Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q71HN5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 87FE1AA5900494FE

FASTA26529,611
        10         20         30         40         50         60 
MNTYKPYSER AKQHSNACAR SLLELMERKQ TNLSVAVDVT TKKELISIAD AIGPYICVLK 

        70         80         90        100        110        120 
THIDIVEDFD ADLIQQLQEL AKKHDFLFFE DRKFADIGNT VKHQYANGIY KIASWSHITN 

       130        140        150        160        170        180 
AHTVPGEGII KGLAEVGLPL GRGLLLLAEM SSKGALTKGS YTTDSVEMAR RNKDFVFGFI 

       190        200        210        220        230        240 
AQNKMNQYDD EDFIVMSPGV GLDVKGDGLG QQYRTPREVI VESGADVIIV GRGIYGQPDK 

       250        260 
LVEQAQRYRQ AGWDAYLERL ALHNK 

« Hide

References

[1]"Homologous recombination and double-strand break repair in the transformation of Rhizopus oryzae."
Skory C.D.
Mol. Genet. Genomics 268:397-406(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 9363 / NRRL 395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF497632 Genomic DNA. Translation: AAN78311.1.

3D structure databases

ProteinModelPortalQ71HN5.
SMRQ71HN5. Positions 5-261.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OMAMGQQYRT.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_RHIOR
AccessionPrimary (citable) accession number: Q71HN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways