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Protein

Immunoglobulin-like domain-containing receptor 2

Gene

ILDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in lipid homeostasis and ER stress pathways.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-like domain-containing receptor 2
Gene namesi
Name:ILDR2
Synonyms:C1orf32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18131. ILDR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 186166LumenalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 639432CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720916.

Polymorphism and mutation databases

BioMutaiILDR2.
DMDMi74749770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 639619Immunoglobulin-like domain-containing receptor 2PRO_0000278607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 145By similarity
Modified residuei473 – 4731PhosphoserineBy similarity
Modified residuei579 – 5791PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ71H61.
PaxDbiQ71H61.
PeptideAtlasiQ71H61.
PRIDEiQ71H61.

PTM databases

iPTMnetiQ71H61.
PhosphoSiteiQ71H61.
SwissPalmiQ71H61.

Expressioni

Gene expression databases

BgeeiQ71H61.
CleanExiHS_ILDR2.
ExpressionAtlasiQ71H61. baseline and differential.
GenevisibleiQ71H61. HS.

Organism-specific databases

HPAiHPA012545.

Interactioni

Protein-protein interaction databases

IntActiQ71H61. 1 interaction.
MINTiMINT-3975840.
STRINGi9606.ENSP00000271417.

Structurei

3D structure databases

ProteinModelPortaliQ71H61.
SMRiQ71H61. Positions 112-147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 162142Ig-like V-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi207 – 23125Cys-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE5P. Eukaryota.
ENOG410XYIF. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000253962.
InParanoidiQ71H61.
OMAiPGPYYIP.
OrthoDBiEOG7B8S3X.
PhylomeDBiQ71H61.
TreeFamiTF330877.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q71H61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVLLRWIS LFWLTAMVEG LQVTVPDKKK VAMLFQPTVL RCHFSTSSHQ
60 70 80 90 100
PAVVQWKFKS YCQDRMGESL GMSSTRAQSL SKRNLEWDPY LDCLDSRRTV
110 120 130 140 150
RVVASKQGST VTLGDFYRGR EITIVHDADL QIGKLMWGDS GLYYCIITTP
160 170 180 190 200
DDLEGKNEDS VELLVLGRTG LLADLLPSFA VEIMPEWVFV GLVLLGVFLF
210 220 230 240 250
FVLVGICWCQ CCPHSCCCYV RCPCCPDSCC CPQALYEAGK AAKAGYPPSV
260 270 280 290 300
SGVPGPYSIP SVPLGGAPSS GMLMDKPHPP PLAPSDSTGG SHSVRKGYRI
310 320 330 340 350
QADKERDSMK VLYYVEKELA QFDPARRMRG RYNNTISELS SLHEEDSNFR
360 370 380 390 400
QSFHQMRSKQ FPVSGDLESN PDYWSGVMGG SSGASRGPSA MEYNKEDRES
410 420 430 440 450
FRHSQPRSKS EMLSRKNFAT GVPAVSMDEL AAFADSYGQR PRRADGNSHE
460 470 480 490 500
ARGGSRFERS ESRAHSGFYQ DDSLEEYYGQ RSRSREPLTD ADRGWAFSPA
510 520 530 540 550
RRRPAEDAHL PRLVSRTPGT APKYDHSYLG SARERQARPE GASRGGSLET
560 570 580 590 600
PSKRSAQLGP RSASYYAWSP PGTYKAGSSQ DDQEDASDDA LPPYSELELT
610 620 630
RGPSYRGRDL PYHSNSEKKR KKEPAKKTND FPTRMSLVV
Length:639
Mass (Da):71,200
Last modified:July 5, 2004 - v1
Checksum:iCBC1067684102090
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021V → I.
Corresponds to variant rs33958744 [ dbSNP | Ensembl ].
VAR_049948

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503509 mRNA. Translation: AAQ07593.1.
AL009182 Genomic DNA. Translation: CAI22773.1.
CCDSiCCDS1256.1.
RefSeqiNP_955383.1. NM_199351.2.
UniGeneiHs.444835.

Genome annotation databases

EnsembliENST00000271417; ENSP00000271417; ENSG00000143195.
GeneIDi387597.
KEGGihsa:387597.
UCSCiuc001gdx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503509 mRNA. Translation: AAQ07593.1.
AL009182 Genomic DNA. Translation: CAI22773.1.
CCDSiCCDS1256.1.
RefSeqiNP_955383.1. NM_199351.2.
UniGeneiHs.444835.

3D structure databases

ProteinModelPortaliQ71H61.
SMRiQ71H61. Positions 112-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ71H61. 1 interaction.
MINTiMINT-3975840.
STRINGi9606.ENSP00000271417.

PTM databases

iPTMnetiQ71H61.
PhosphoSiteiQ71H61.
SwissPalmiQ71H61.

Polymorphism and mutation databases

BioMutaiILDR2.
DMDMi74749770.

Proteomic databases

MaxQBiQ71H61.
PaxDbiQ71H61.
PeptideAtlasiQ71H61.
PRIDEiQ71H61.

Protocols and materials databases

DNASUi387597.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271417; ENSP00000271417; ENSG00000143195.
GeneIDi387597.
KEGGihsa:387597.
UCSCiuc001gdx.3. human.

Organism-specific databases

CTDi387597.
GeneCardsiILDR2.
HGNCiHGNC:18131. ILDR2.
HPAiHPA012545.
neXtProtiNX_Q71H61.
PharmGKBiPA164720916.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5P. Eukaryota.
ENOG410XYIF. LUCA.
GeneTreeiENSGT00430000030906.
HOGENOMiHOG000253962.
InParanoidiQ71H61.
OMAiPGPYYIP.
OrthoDBiEOG7B8S3X.
PhylomeDBiQ71H61.
TreeFamiTF330877.

Miscellaneous databases

ChiTaRSiILDR2. human.
GenomeRNAii387597.
PROiQ71H61.

Gene expression databases

BgeeiQ71H61.
CleanExiHS_ILDR2.
ExpressionAtlasiQ71H61. baseline and differential.
GenevisibleiQ71H61. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR008664. LISCH7.
[Graphical view]
PfamiPF05624. LSR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Schulz H.L., Stohr H., Weber B.H.F.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiILDR2_HUMAN
AccessioniPrimary (citable) accession number: Q71H61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.