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Protein

Immunoglobulin-like domain-containing receptor 2

Gene

ILDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in lipid homeostasis and ER stress pathways.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-like domain-containing receptor 2
Gene namesi
Name:ILDR2
Synonyms:C1orf32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143195.12
HGNCiHGNC:18131 ILDR2
neXtProtiNX_Q71H61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 186LumenalSequence analysisAdd BLAST166
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 639CytoplasmicSequence analysisAdd BLAST432

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi387597
OpenTargetsiENSG00000143195
PharmGKBiPA164720916

Polymorphism and mutation databases

BioMutaiILDR2
DMDMi74749770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000027860721 – 639Immunoglobulin-like domain-containing receptor 2Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 145By similarity
Modified residuei473PhosphoserineBy similarity1
Modified residuei544Omega-N-methylarginineBy similarity1
Modified residuei579PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ71H61
PaxDbiQ71H61
PeptideAtlasiQ71H61
PRIDEiQ71H61

PTM databases

iPTMnetiQ71H61
PhosphoSitePlusiQ71H61
SwissPalmiQ71H61

Expressioni

Gene expression databases

BgeeiENSG00000143195
CleanExiHS_ILDR2
ExpressionAtlasiQ71H61 baseline and differential
GenevisibleiQ71H61 HS

Organism-specific databases

HPAiHPA012545

Interactioni

Protein-protein interaction databases

BioGridi1323642 interactors.
IntActiQ71H61 1 interactor.
MINTiQ71H61

Structurei

3D structure databases

ProteinModelPortaliQ71H61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 162Ig-like V-typeAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi207 – 231Cys-richAdd BLAST25

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE5P Eukaryota
ENOG410XYIF LUCA
GeneTreeiENSGT00430000030906
HOGENOMiHOG000253962
InParanoidiQ71H61
OMAiSDFPTRM
OrthoDBiEOG091G0875
PhylomeDBiQ71H61
TreeFamiTF330877

Family and domain databases

InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR003599 Ig_sub
IPR008664 LISCH7
PfamiView protein in Pfam
PF05624 LSR, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q71H61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVLLRWIS LFWLTAMVEG LQVTVPDKKK VAMLFQPTVL RCHFSTSSHQ
60 70 80 90 100
PAVVQWKFKS YCQDRMGESL GMSSTRAQSL SKRNLEWDPY LDCLDSRRTV
110 120 130 140 150
RVVASKQGST VTLGDFYRGR EITIVHDADL QIGKLMWGDS GLYYCIITTP
160 170 180 190 200
DDLEGKNEDS VELLVLGRTG LLADLLPSFA VEIMPEWVFV GLVLLGVFLF
210 220 230 240 250
FVLVGICWCQ CCPHSCCCYV RCPCCPDSCC CPQALYEAGK AAKAGYPPSV
260 270 280 290 300
SGVPGPYSIP SVPLGGAPSS GMLMDKPHPP PLAPSDSTGG SHSVRKGYRI
310 320 330 340 350
QADKERDSMK VLYYVEKELA QFDPARRMRG RYNNTISELS SLHEEDSNFR
360 370 380 390 400
QSFHQMRSKQ FPVSGDLESN PDYWSGVMGG SSGASRGPSA MEYNKEDRES
410 420 430 440 450
FRHSQPRSKS EMLSRKNFAT GVPAVSMDEL AAFADSYGQR PRRADGNSHE
460 470 480 490 500
ARGGSRFERS ESRAHSGFYQ DDSLEEYYGQ RSRSREPLTD ADRGWAFSPA
510 520 530 540 550
RRRPAEDAHL PRLVSRTPGT APKYDHSYLG SARERQARPE GASRGGSLET
560 570 580 590 600
PSKRSAQLGP RSASYYAWSP PGTYKAGSSQ DDQEDASDDA LPPYSELELT
610 620 630
RGPSYRGRDL PYHSNSEKKR KKEPAKKTND FPTRMSLVV
Length:639
Mass (Da):71,200
Last modified:July 5, 2004 - v1
Checksum:iCBC1067684102090
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049948202V → I. Corresponds to variant dbSNP:rs33958744Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503509 mRNA Translation: AAQ07593.1
AL009182 Genomic DNA No translation available.
CCDSiCCDS1256.1
RefSeqiNP_955383.1, NM_199351.2
UniGeneiHs.444835

Genome annotation databases

EnsembliENST00000271417; ENSP00000271417; ENSG00000143195
GeneIDi387597
KEGGihsa:387597
UCSCiuc001gdx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiILDR2_HUMAN
AccessioniPrimary (citable) accession number: Q71H61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome