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Protein
Submitted name:

Matrix metalloproteinase 13

Gene

mmp13a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • collagen catabolic process Source: InterPro
  • macrophage chemotaxis Source: ZFIN

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandCalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Protein family/group databases

MEROPSiM10.018.

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metalloproteinase 13Imported
Gene namesi
Name:mmp13aImported
Synonyms:mmp13Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-031202-2. mmp13a.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500428394820 – 475Sequence analysisAdd BLAST456

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ71G59.

Structurei

3D structure databases

ProteinModelPortaliQ71G59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 268ZnMcInterPro annotationAdd BLAST161

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000217927.
HOVERGENiHBG052484.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR028711. Collagenase_3.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR021158. Pept_M10A_Zn_BS.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF185. PTHR10201:SF185. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS00546. CYSTEINE_SWITCH. 1 hit.
PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q71G59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTCFRLCVF ITLLFSGHSS PIAPPAGGDQ DTLAENYLTR LYGLPKPAQN
60 70 80 90 100
PSPSGGEKRS SDVSLRLKEM QQFFKLKVSG KLDQETLEVM KKPRCGVPDI
110 120 130 140 150
KAYSTFAGDY KWKKHQLTYR IGNYTPDMSV AEVDDSISKA LKVWADVTPL
160 170 180 190 200
RFTRIYSGTA DIMISFATGD HRDGYPFDGP NGFLAHAFPP FEGIGGDAHF
210 220 230 240 250
DDDETFSYRS PQYYNLFLVA AHEFGHSLGL EHSQDPGALM YPTYVYRDVD
260 270 280 290 300
RFVLPRDDVN GIQSLYGPNT DVNTDDSKPT PPVTPNTCDP NLVLDAVTML
310 320 330 340 350
RGEIMFFKNS FFWRSYPQSA DVEQQLIKSF WPEAPDNIDA AFESVMQDKV
360 370 380 390 400
FLIKGEKVWA LYGYDMVQGY PKSLSMFRLP KNVRKIDAVL YKEDSNSILF
410 420 430 440 450
FANNQVYSYN EGIRQMDKGF PKPVEEVFPG MTGKVTAAFQ YRGLNYLFSG
460 470
SKMLEFGSNN RLFRVLNNNY FLPCK
Length:475
Mass (Da):53,792
Last modified:July 5, 2004 - v1
Checksum:i90F93E82B37B2CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506756 mRNA. Translation: AAQ07962.1.
UniGeneiDr.81475.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ71G59_DANRE
AccessioniPrimary (citable) accession number: Q71G59
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)