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Protein

Filamin-binding LIM protein 1

Gene

Fblim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell shape

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-446353. Cell-extracellular matrix interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-binding LIM protein 1
Short name:
FBLP-1
Alternative name(s):
CSX-associated LIM
Gene namesi
Name:Fblim1
Synonyms:Cal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921452. Fblim1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757331 – 375Filamin-binding LIM protein 1Add BLAST375

Proteomic databases

MaxQBiQ71FD7.
PaxDbiQ71FD7.
PeptideAtlasiQ71FD7.
PRIDEiQ71FD7.

PTM databases

iPTMnetiQ71FD7.
PhosphoSitePlusiQ71FD7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006219.
CleanExiMM_FBLIM1.
ExpressionAtlasiQ71FD7. baseline and differential.
GenevisibleiQ71FD7. MM.

Interactioni

Subunit structurei

Interacts with FERMT2, FLNA, FLNB and FLNC (By similarity). Interacts with NKX2-5.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ71FD7. 2 interactors.
MINTiMINT-4123317.
STRINGi10090.ENSMUSP00000006381.

Structurei

3D structure databases

ProteinModelPortaliQ71FD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 244LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini245 – 302LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini303 – 372LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 84Intrinsically disorderedBy similarityAdd BLAST84
Regioni1 – 69Filamin-bindingBy similarityAdd BLAST69
Regioni278 – 375FERMT2-bindingBy similarityAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 176Pro-richAdd BLAST90

Domaini

The N-terminal region is intrinsically disordered.By similarity

Sequence similaritiesi

Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000007533.
HOVERGENiHBG051561.
InParanoidiQ71FD7.
OMAiNRLFCKP.
OrthoDBiEOG091G0CJO.
TreeFamiTF320310.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 3 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q71FD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKPEKRVA SSVFITLAPP RRDVAVSEEV GQAACEARRA RPWEMLPTKT
60 70 80 90 100
PGAAVGRSPK TWTPSGKTNA SLSGVTPQLS NGGCSLPPPS LNEEDLDLPP
110 120 130 140 150
PPPPPSAYLP LPEEEPPVLP GKSLISDLEQ LHLPPPPPPP PPQAPSKGSS
160 170 180 190 200
VHPPPGHAIP SEEELPPPPE EPVTLPEREV STDVCGFCHK PVSPRELAVE
210 220 230 240 250
AMKRQYHAQC FTCRTCRRQL AGQRFYQKDG RPLCEPCYQD TLEKCGKCGE
260 270 280 290 300
VVQEHVIRAL GKAFHPPCFT CVTCARCISD ESFALDSQNQ VYCVADFYRK
310 320 330 340 350
FAPVCSICEN PIIPRDGKDA FKIECMGRNF HENCYRCEDC SVLLSVEPTD
360 370
QGCYPLNDHL FCKPCHLKRS AAGCC
Length:375
Mass (Da):41,026
Last modified:July 27, 2011 - v2
Checksum:i601DF99A8EB1BB80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → R in AAQ08090 (PubMed:14757752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513359 mRNA. Translation: AAQ08090.1.
AK154680 mRNA. Translation: BAE32761.1.
AK170151 mRNA. Translation: BAE41598.1.
AK170440 mRNA. Translation: BAE41798.1.
AL670446 Genomic DNA. Translation: CAM19893.1.
CH466615 Genomic DNA. Translation: EDL13381.1.
CH466615 Genomic DNA. Translation: EDL13382.1.
CH466615 Genomic DNA. Translation: EDL13383.1.
CH466615 Genomic DNA. Translation: EDL13384.1.
CH466615 Genomic DNA. Translation: EDL13385.1.
CH466615 Genomic DNA. Translation: EDL13386.1.
BC004777 mRNA. Translation: AAH04777.1.
CCDSiCCDS18876.1.
RefSeqiNP_001156728.1. NM_001163256.1.
NP_598515.3. NM_133754.5.
XP_006539277.1. XM_006539214.3.
XP_006539278.1. XM_006539215.3.
XP_006539279.1. XM_006539216.3.
UniGeneiMm.490327.

Genome annotation databases

EnsembliENSMUST00000006381; ENSMUSP00000006381; ENSMUSG00000006219.
ENSMUST00000105784; ENSMUSP00000101410; ENSMUSG00000006219.
ENSMUST00000105785; ENSMUSP00000101411; ENSMUSG00000006219.
GeneIDi74202.
KEGGimmu:74202.
UCSCiuc008vos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF513359 mRNA. Translation: AAQ08090.1.
AK154680 mRNA. Translation: BAE32761.1.
AK170151 mRNA. Translation: BAE41598.1.
AK170440 mRNA. Translation: BAE41798.1.
AL670446 Genomic DNA. Translation: CAM19893.1.
CH466615 Genomic DNA. Translation: EDL13381.1.
CH466615 Genomic DNA. Translation: EDL13382.1.
CH466615 Genomic DNA. Translation: EDL13383.1.
CH466615 Genomic DNA. Translation: EDL13384.1.
CH466615 Genomic DNA. Translation: EDL13385.1.
CH466615 Genomic DNA. Translation: EDL13386.1.
BC004777 mRNA. Translation: AAH04777.1.
CCDSiCCDS18876.1.
RefSeqiNP_001156728.1. NM_001163256.1.
NP_598515.3. NM_133754.5.
XP_006539277.1. XM_006539214.3.
XP_006539278.1. XM_006539215.3.
XP_006539279.1. XM_006539216.3.
UniGeneiMm.490327.

3D structure databases

ProteinModelPortaliQ71FD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ71FD7. 2 interactors.
MINTiMINT-4123317.
STRINGi10090.ENSMUSP00000006381.

PTM databases

iPTMnetiQ71FD7.
PhosphoSitePlusiQ71FD7.

Proteomic databases

MaxQBiQ71FD7.
PaxDbiQ71FD7.
PeptideAtlasiQ71FD7.
PRIDEiQ71FD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006381; ENSMUSP00000006381; ENSMUSG00000006219.
ENSMUST00000105784; ENSMUSP00000101410; ENSMUSG00000006219.
ENSMUST00000105785; ENSMUSP00000101411; ENSMUSG00000006219.
GeneIDi74202.
KEGGimmu:74202.
UCSCiuc008vos.2. mouse.

Organism-specific databases

CTDi54751.
MGIiMGI:1921452. Fblim1.

Phylogenomic databases

eggNOGiKOG1701. Eukaryota.
ENOG410Y3GP. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000007533.
HOVERGENiHBG051561.
InParanoidiQ71FD7.
OMAiNRLFCKP.
OrthoDBiEOG091G0CJO.
TreeFamiTF320310.

Enzyme and pathway databases

ReactomeiR-MMU-446353. Cell-extracellular matrix interactions.

Miscellaneous databases

ChiTaRSiFblim1. mouse.
PROiQ71FD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006219.
CleanExiMM_FBLIM1.
ExpressionAtlasiQ71FD7. baseline and differential.
GenevisibleiQ71FD7. MM.

Family and domain databases

Gene3Di2.10.110.10. 3 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 3 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBLI1_MOUSE
AccessioniPrimary (citable) accession number: Q71FD7
Secondary accession number(s): Q3TDK3, Q99J35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.