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Q71F23

- CENPU_HUMAN

UniProt

Q71F23 - CENPU_HUMAN

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Protein
Centromere protein U
Gene
CENPU, ICEN24, KLIP1, MLF1IP, PBIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.3 Publications

GO - Biological processi

  1. centromere-specific nucleosome assembly Source: Reactome
  2. mitotic cell cycle Source: Reactome
  3. nucleosome assembly Source: Reactome
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein U
Short name:
CENP-U
Alternative name(s):
Centromere protein of 50 kDa
Short name:
CENP-50
Interphase centromere complex protein 24
KSHV latent nuclear antigen-interacting protein 1
MLF1-interacting protein
Polo-box-interacting protein 1
Gene namesi
Name:CENPU
Synonyms:ICEN24, KLIP1, MLF1IP, PBIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:21348. CENPU.

Subcellular locationi

Cytoplasm. Nucleus. Chromosomecentromerekinetochore
Note: Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.5 Publications

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. microtubule organizing center Source: HPA
  4. nucleoplasm Source: Reactome
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi77 – 771S → A: Insensitive to PLK1-induced degradation. 1 Publication
Mutagenesisi78 – 781T → A: Insensitive to PLK1-induced degradation. 1 Publication
Mutagenesisi78 – 781T → D: Failed to enhance the PLK1-dependent degradation. 1 Publication
Mutagenesisi78 – 781T → E: Failed to enhance the PLK1-dependent degradation. 1 Publication

Organism-specific databases

PharmGKBiPA134893791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Centromere protein U
PRO_0000247672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphothreonine; by PLK11 Publication
Modified residuei110 – 1101Phosphothreonine1 Publication
Modified residuei111 – 1111Phosphoserine2 Publications
Modified residuei136 – 1361Phosphoserine1 Publication
Modified residuei139 – 1391Phosphoserine1 Publication
Modified residuei141 – 1411Phosphoserine1 Publication
Modified residuei194 – 1941Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ71F23.
PaxDbiQ71F23.
PRIDEiQ71F23.

PTM databases

PhosphoSiteiQ71F23.

Expressioni

Tissue specificityi

Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.3 Publications

Gene expression databases

ArrayExpressiQ71F23.
BgeeiQ71F23.
CleanExiHS_MLF1IP.
GenevestigatoriQ71F23.

Organism-specific databases

HPAiHPA022048.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.5 Publications

Protein-protein interaction databases

BioGridi122805. 32 interactions.
DIPiDIP-48539N.
IntActiQ71F23. 12 interactions.
MINTiMINT-4992596.
STRINGi9606.ENSP00000281453.

Structurei

3D structure databases

ProteinModelPortaliQ71F23.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili297 – 35660 Reviewed prediction
Add
BLAST
Coiled coili397 – 41721 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 2318Nuclear localization signal Reviewed prediction
Add
BLAST
Motifi303 – 32018Nuclear localization signal Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG45595.
HOGENOMiHOG000236255.
HOVERGENiHBG081090.
InParanoidiQ71F23.
KOiK11513.
OMAiLGENEKD.
OrthoDBiEOG7PS1FG.
PhylomeDBiQ71F23.
TreeFamiTF330780.

Family and domain databases

InterProiIPR025214. CENP-U.
[Graphical view]
PfamiPF13097. CENP-U. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q71F23-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS    50
DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP 100
GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK 150
VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL 200
AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE 250
LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT 300
NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS 350
LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA 400
ESHLRNINHQ LEKLLDQG 418
Length:418
Mass (Da):47,522
Last modified:July 5, 2004 - v1
Checksum:iA99BC012EF7188F9
GO
Isoform 2 (identifier: Q71F23-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Show »
Length:176
Mass (Da):20,710
Checksum:iC5731EE5F7ADCE1D
GO
Isoform 3 (identifier: Q71F23-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-337: EPQLKQL → WTGAGLW
     338-418: Missing.

Show »
Length:337
Mass (Da):38,102
Checksum:i24A4BBC85B3E98E1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161G → R.
Corresponds to variant rs902174 [ dbSNP | Ensembl ].
VAR_048692
Natural varianti16 – 161G → S.
Corresponds to variant rs902174 [ dbSNP | Ensembl ].
VAR_027144
Natural varianti157 – 1571I → T.
Corresponds to variant rs6552804 [ dbSNP | Ensembl ].
VAR_027145
Natural varianti214 – 2141I → M.
Corresponds to variant rs4616798 [ dbSNP | Ensembl ].
VAR_027146
Natural varianti279 – 2791A → T.
Corresponds to variant rs34007339 [ dbSNP | Ensembl ].
VAR_048693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 242242Missing in isoform 2.
VSP_020030Add
BLAST
Alternative sequencei331 – 3377EPQLKQL → WTGAGLW in isoform 3.
VSP_053526
Alternative sequencei338 – 41881Missing in isoform 3.
VSP_053527Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631E → G in AAI07745. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF469667 mRNA. Translation: AAQ05290.1.
AF516710 mRNA. Translation: AAQ08228.1.
AK027121 mRNA. Translation: BAB15665.1.
CR457376 mRNA. Translation: CAG33657.1.
DQ907910 mRNA. Translation: ABI49142.1.
AC079257 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04666.1.
BC107744 mRNA. Translation: AAI07745.1.
BC031520 mRNA. Translation: AAH31520.1.
BC131556 mRNA. Translation: AAI31557.1.
CCDSiCCDS3838.1. [Q71F23-1]
RefSeqiNP_078905.2. NM_024629.3. [Q71F23-1]
UniGeneiHs.575032.

Genome annotation databases

EnsembliENST00000281453; ENSP00000281453; ENSG00000151725. [Q71F23-1]
ENST00000541971; ENSP00000445862; ENSG00000151725. [Q71F23-3]
GeneIDi79682.
KEGGihsa:79682.
UCSCiuc003iwq.3. human. [Q71F23-1]

Polymorphism databases

DMDMi74712714.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF469667 mRNA. Translation: AAQ05290.1 .
AF516710 mRNA. Translation: AAQ08228.1 .
AK027121 mRNA. Translation: BAB15665.1 .
CR457376 mRNA. Translation: CAG33657.1 .
DQ907910 mRNA. Translation: ABI49142.1 .
AC079257 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04666.1 .
BC107744 mRNA. Translation: AAI07745.1 .
BC031520 mRNA. Translation: AAH31520.1 .
BC131556 mRNA. Translation: AAI31557.1 .
CCDSi CCDS3838.1. [Q71F23-1 ]
RefSeqi NP_078905.2. NM_024629.3. [Q71F23-1 ]
UniGenei Hs.575032.

3D structure databases

ProteinModelPortali Q71F23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122805. 32 interactions.
DIPi DIP-48539N.
IntActi Q71F23. 12 interactions.
MINTi MINT-4992596.
STRINGi 9606.ENSP00000281453.

PTM databases

PhosphoSitei Q71F23.

Polymorphism databases

DMDMi 74712714.

Proteomic databases

MaxQBi Q71F23.
PaxDbi Q71F23.
PRIDEi Q71F23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281453 ; ENSP00000281453 ; ENSG00000151725 . [Q71F23-1 ]
ENST00000541971 ; ENSP00000445862 ; ENSG00000151725 . [Q71F23-3 ]
GeneIDi 79682.
KEGGi hsa:79682.
UCSCi uc003iwq.3. human. [Q71F23-1 ]

Organism-specific databases

CTDi 79682.
GeneCardsi GC04M185615.
HGNCi HGNC:21348. CENPU.
HPAi HPA022048.
MIMi 611511. gene.
neXtProti NX_Q71F23.
PharmGKBi PA134893791.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45595.
HOGENOMi HOG000236255.
HOVERGENi HBG081090.
InParanoidi Q71F23.
KOi K11513.
OMAi LGENEKD.
OrthoDBi EOG7PS1FG.
PhylomeDBi Q71F23.
TreeFami TF330780.

Enzyme and pathway databases

Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

GeneWikii MLF1IP.
GenomeRNAii 79682.
NextBioi 68934.
PROi Q71F23.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q71F23.
Bgeei Q71F23.
CleanExi HS_MLF1IP.
Genevestigatori Q71F23.

Family and domain databases

InterProi IPR025214. CENP-U.
[Graphical view ]
Pfami PF13097. CENP-U. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus."
    Pan H.-Y., Zhang Y.-J., Wang X.-P., Deng J.-H., Zhou F.-C., Gao S.-J.
    J. Virol. 77:9758-9768(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS LATENT NUCLEAR ANTIGEN.
  2. "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP."
    Hanissian S.H., Akbar U., Teng B., Janjetovic Z., Hoffmann A., Hitzler J.K., Iscove N., Hamre K., Du X., Tong Y., Mukatira S., Robertson J.H., Morris S.W.
    Oncogene 23:3700-3707(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MLF1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Role of alternatively spliced MLF1IP isoforms in brain tumor pathogenesis."
    Hanissian S.H.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Glioblastoma.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal cortex and Testis.
  9. "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma."
    Hanissian S.H., Teng B., Akbar U., Janjetovic Z., Zhou Q., Duntsch C., Robertson J.H.
    Brain Res. 1047:56-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
    Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
    Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ AND CENPR.
  12. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPM; CENPN AND CENPT.
  13. "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation."
    Kang Y.H., Park J.-E., Yu L.-R., Soung N.-K., Yun S.-M., Bang J.K., Seong Y.-S., Yu H., Garfield S., Veenstra T.D., Lee K.S.
    Mol. Cell 24:409-422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK1, PHOSPHORYLATION AT THR-78, MUTAGENESIS OF SER-77 AND THR-78.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; SER-111; SER-136; SER-139 AND SER-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPU_HUMAN
AccessioniPrimary (citable) accession number: Q71F23
Secondary accession number(s): A2RRD9
, Q09GN2, Q32Q71, Q9H5G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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