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Q71F23

- CENPU_HUMAN

UniProt

Q71F23 - CENPU_HUMAN

Protein

Centromere protein U

Gene

CENPU

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.3 Publications

    GO - Biological processi

    1. CENP-A containing nucleosome assembly Source: Reactome
    2. mitotic cell cycle Source: Reactome
    3. nucleosome assembly Source: Reactome
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW
    6. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centromere protein U
    Short name:
    CENP-U
    Alternative name(s):
    Centromere protein of 50 kDa
    Short name:
    CENP-50
    Interphase centromere complex protein 24
    KSHV latent nuclear antigen-interacting protein 1
    MLF1-interacting protein
    Polo-box-interacting protein 1
    Gene namesi
    Name:CENPU
    Synonyms:ICEN24, KLIP1, MLF1IP, PBIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:21348. CENPU.

    Subcellular locationi

    Cytoplasm. Nucleus. Chromosomecentromerekinetochore
    Note: Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. microtubule organizing center Source: HPA
    4. nucleoplasm Source: Reactome
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi77 – 771S → A: Insensitive to PLK1-induced degradation. 1 Publication
    Mutagenesisi78 – 781T → A: Insensitive to PLK1-induced degradation. 1 Publication
    Mutagenesisi78 – 781T → D: Failed to enhance the PLK1-dependent degradation. 1 Publication
    Mutagenesisi78 – 781T → E: Failed to enhance the PLK1-dependent degradation. 1 Publication

    Organism-specific databases

    PharmGKBiPA134893791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Centromere protein UPRO_0000247672Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei78 – 781Phosphothreonine; by PLK11 Publication
    Modified residuei110 – 1101Phosphothreonine1 Publication
    Modified residuei111 – 1111Phosphoserine2 Publications
    Modified residuei136 – 1361Phosphoserine1 Publication
    Modified residuei139 – 1391Phosphoserine1 Publication
    Modified residuei141 – 1411Phosphoserine1 Publication
    Modified residuei194 – 1941Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ71F23.
    PaxDbiQ71F23.
    PRIDEiQ71F23.

    PTM databases

    PhosphoSiteiQ71F23.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.3 Publications

    Gene expression databases

    ArrayExpressiQ71F23.
    BgeeiQ71F23.
    CleanExiHS_MLF1IP.
    GenevestigatoriQ71F23.

    Organism-specific databases

    HPAiHPA022048.

    Interactioni

    Subunit structurei

    Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.5 Publications

    Protein-protein interaction databases

    BioGridi122805. 32 interactions.
    DIPiDIP-48539N.
    IntActiQ71F23. 12 interactions.
    MINTiMINT-4992596.
    STRINGi9606.ENSP00000281453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ71F23.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili297 – 35660Sequence AnalysisAdd
    BLAST
    Coiled coili397 – 41721Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi6 – 2318Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi303 – 32018Nuclear localization signalSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG45595.
    HOGENOMiHOG000236255.
    HOVERGENiHBG081090.
    InParanoidiQ71F23.
    KOiK11513.
    OMAiLGENEKD.
    OrthoDBiEOG7PS1FG.
    PhylomeDBiQ71F23.
    TreeFamiTF330780.

    Family and domain databases

    InterProiIPR025214. CENP-U.
    [Graphical view]
    PfamiPF13097. CENP-U. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q71F23-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS    50
    DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP 100
    GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK 150
    VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL 200
    AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE 250
    LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT 300
    NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS 350
    LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA 400
    ESHLRNINHQ LEKLLDQG 418
    Length:418
    Mass (Da):47,522
    Last modified:July 5, 2004 - v1
    Checksum:iA99BC012EF7188F9
    GO
    Isoform 2 (identifier: Q71F23-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-242: Missing.

    Show »
    Length:176
    Mass (Da):20,710
    Checksum:iC5731EE5F7ADCE1D
    GO
    Isoform 3 (identifier: Q71F23-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         331-337: EPQLKQL → WTGAGLW
         338-418: Missing.

    Show »
    Length:337
    Mass (Da):38,102
    Checksum:i24A4BBC85B3E98E1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631E → G in AAI07745. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161G → R.
    Corresponds to variant rs902174 [ dbSNP | Ensembl ].
    VAR_048692
    Natural varianti16 – 161G → S.
    Corresponds to variant rs902174 [ dbSNP | Ensembl ].
    VAR_027144
    Natural varianti157 – 1571I → T.
    Corresponds to variant rs6552804 [ dbSNP | Ensembl ].
    VAR_027145
    Natural varianti214 – 2141I → M.
    Corresponds to variant rs4616798 [ dbSNP | Ensembl ].
    VAR_027146
    Natural varianti279 – 2791A → T.
    Corresponds to variant rs34007339 [ dbSNP | Ensembl ].
    VAR_048693

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 242242Missing in isoform 2. 3 PublicationsVSP_020030Add
    BLAST
    Alternative sequencei331 – 3377EPQLKQL → WTGAGLW in isoform 3. 1 PublicationVSP_053526
    Alternative sequencei338 – 41881Missing in isoform 3. 1 PublicationVSP_053527Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF469667 mRNA. Translation: AAQ05290.1.
    AF516710 mRNA. Translation: AAQ08228.1.
    AK027121 mRNA. Translation: BAB15665.1.
    CR457376 mRNA. Translation: CAG33657.1.
    DQ907910 mRNA. Translation: ABI49142.1.
    AC079257 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04666.1.
    BC107744 mRNA. Translation: AAI07745.1.
    BC031520 mRNA. Translation: AAH31520.1.
    BC131556 mRNA. Translation: AAI31557.1.
    CCDSiCCDS3838.1. [Q71F23-1]
    RefSeqiNP_078905.2. NM_024629.3. [Q71F23-1]
    UniGeneiHs.575032.

    Genome annotation databases

    EnsembliENST00000281453; ENSP00000281453; ENSG00000151725. [Q71F23-1]
    GeneIDi79682.
    KEGGihsa:79682.
    UCSCiuc003iwq.3. human. [Q71F23-1]

    Polymorphism databases

    DMDMi74712714.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF469667 mRNA. Translation: AAQ05290.1 .
    AF516710 mRNA. Translation: AAQ08228.1 .
    AK027121 mRNA. Translation: BAB15665.1 .
    CR457376 mRNA. Translation: CAG33657.1 .
    DQ907910 mRNA. Translation: ABI49142.1 .
    AC079257 Genomic DNA. No translation available.
    CH471056 Genomic DNA. Translation: EAX04666.1 .
    BC107744 mRNA. Translation: AAI07745.1 .
    BC031520 mRNA. Translation: AAH31520.1 .
    BC131556 mRNA. Translation: AAI31557.1 .
    CCDSi CCDS3838.1. [Q71F23-1 ]
    RefSeqi NP_078905.2. NM_024629.3. [Q71F23-1 ]
    UniGenei Hs.575032.

    3D structure databases

    ProteinModelPortali Q71F23.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122805. 32 interactions.
    DIPi DIP-48539N.
    IntActi Q71F23. 12 interactions.
    MINTi MINT-4992596.
    STRINGi 9606.ENSP00000281453.

    PTM databases

    PhosphoSitei Q71F23.

    Polymorphism databases

    DMDMi 74712714.

    Proteomic databases

    MaxQBi Q71F23.
    PaxDbi Q71F23.
    PRIDEi Q71F23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281453 ; ENSP00000281453 ; ENSG00000151725 . [Q71F23-1 ]
    GeneIDi 79682.
    KEGGi hsa:79682.
    UCSCi uc003iwq.3. human. [Q71F23-1 ]

    Organism-specific databases

    CTDi 79682.
    GeneCardsi GC04M185615.
    HGNCi HGNC:21348. CENPU.
    HPAi HPA022048.
    MIMi 611511. gene.
    neXtProti NX_Q71F23.
    PharmGKBi PA134893791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45595.
    HOGENOMi HOG000236255.
    HOVERGENi HBG081090.
    InParanoidi Q71F23.
    KOi K11513.
    OMAi LGENEKD.
    OrthoDBi EOG7PS1FG.
    PhylomeDBi Q71F23.
    TreeFami TF330780.

    Enzyme and pathway databases

    Reactomei REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
    REACT_682. Mitotic Prometaphase.

    Miscellaneous databases

    GeneWikii MLF1IP.
    GenomeRNAii 79682.
    NextBioi 68934.
    PROi Q71F23.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q71F23.
    Bgeei Q71F23.
    CleanExi HS_MLF1IP.
    Genevestigatori Q71F23.

    Family and domain databases

    InterProi IPR025214. CENP-U.
    [Graphical view ]
    Pfami PF13097. CENP-U. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus."
      Pan H.-Y., Zhang Y.-J., Wang X.-P., Deng J.-H., Zhou F.-C., Gao S.-J.
      J. Virol. 77:9758-9768(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS LATENT NUCLEAR ANTIGEN.
    2. "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP."
      Hanissian S.H., Akbar U., Teng B., Janjetovic Z., Hoffmann A., Hitzler J.K., Iscove N., Hamre K., Du X., Tong Y., Mukatira S., Robertson J.H., Morris S.W.
      Oncogene 23:3700-3707(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MLF1.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Role of alternatively spliced MLF1IP isoforms in brain tumor pathogenesis."
      Hanissian S.H.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Glioblastoma.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adrenal cortex and Testis.
    9. "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma."
      Hanissian S.H., Teng B., Akbar U., Janjetovic Z., Zhou Q., Duntsch C., Robertson J.H.
      Brain Res. 1047:56-64(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
      Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
      Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
      Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
      Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ AND CENPR.
    12. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPM; CENPN AND CENPT.
    13. "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation."
      Kang Y.H., Park J.-E., Yu L.-R., Soung N.-K., Yun S.-M., Bang J.K., Seong Y.-S., Yu H., Garfield S., Veenstra T.D., Lee K.S.
      Mol. Cell 24:409-422(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK1, PHOSPHORYLATION AT THR-78, MUTAGENESIS OF SER-77 AND THR-78.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; SER-111; SER-136; SER-139 AND SER-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCENPU_HUMAN
    AccessioniPrimary (citable) accession number: Q71F23
    Secondary accession number(s): A2RRD9
    , Q09GN2, Q32Q71, Q9H5G1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3