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Protein

Centromere protein U

Gene

CENPU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_355252. RHO GTPases Activate Formins.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein U
Short name:
CENP-U
Alternative name(s):
Centromere protein of 50 kDa
Short name:
CENP-50
Interphase centromere complex protein 24
KSHV latent nuclear antigen-interacting protein 1
MLF1-interacting protein
Polo-box-interacting protein 1
Gene namesi
Name:CENPU
Synonyms:ICEN24, KLIP1, MLF1IP, PBIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21348. CENPU.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi77 – 771S → A: Insensitive to PLK1-induced degradation. 1 Publication
Mutagenesisi78 – 781T → A: Insensitive to PLK1-induced degradation. 1 Publication
Mutagenesisi78 – 781T → D: Failed to enhance the PLK1-dependent degradation. 1 Publication
Mutagenesisi78 – 781T → E: Failed to enhance the PLK1-dependent degradation. 1 Publication

Organism-specific databases

PharmGKBiPA134893791.

Polymorphism and mutation databases

BioMutaiMLF1IP.
DMDMi74712714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Centromere protein UPRO_0000247672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781Phosphothreonine; by PLK11 Publication
Modified residuei110 – 1101Phosphothreonine1 Publication
Modified residuei111 – 1111Phosphoserine2 Publications
Modified residuei136 – 1361Phosphoserine1 Publication
Modified residuei139 – 1391Phosphoserine1 Publication
Modified residuei141 – 1411Phosphoserine1 Publication
Modified residuei194 – 1941Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ71F23.
PaxDbiQ71F23.
PRIDEiQ71F23.

PTM databases

PhosphoSiteiQ71F23.

Expressioni

Tissue specificityi

Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.3 Publications

Gene expression databases

BgeeiQ71F23.
CleanExiHS_MLF1IP.
ExpressionAtlasiQ71F23. baseline and differential.
GenevisibleiQ71F23. HS.

Organism-specific databases

HPAiHPA022048.

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371983EBI-2515234,EBI-347978
TFIP11Q9UBB93EBI-2515234,EBI-1105213

Protein-protein interaction databases

BioGridi122805. 36 interactions.
DIPiDIP-48539N.
IntActiQ71F23. 14 interactions.
MINTiMINT-4992596.
STRINGi9606.ENSP00000281453.

Structurei

3D structure databases

ProteinModelPortaliQ71F23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili297 – 35660Sequence AnalysisAdd
BLAST
Coiled coili397 – 41721Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi6 – 2318Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi303 – 32018Nuclear localization signalSequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG45595.
GeneTreeiENSGT00390000015511.
HOGENOMiHOG000236255.
HOVERGENiHBG081090.
InParanoidiQ71F23.
KOiK11513.
OMAiKQLHQDY.
OrthoDBiEOG7PS1FG.
PhylomeDBiQ71F23.
TreeFamiTF330780.

Family and domain databases

InterProiIPR025214. CENP-U.
[Graphical view]
PfamiPF13097. CENP-U. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q71F23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRGRRRPR PHRSEGARRS KNTLERTHSM KDKAGQKCKP IDVFDFPDNS
60 70 80 90 100
DVSSIGRLGE NEKDEETYET FDPPLHSTAI YADEEEFSKH CGLSLSSTPP
110 120 130 140 150
GKEAKRSSDT SGNEASEIES VKISAKKPGR KLRPISDDSE SIEESDTRRK
160 170 180 190 200
VKSAEKISTQ RHEVIRTTAS SELSEKPAES VTSKKTGPLS AQPSVEKENL
210 220 230 240 250
AIESQSKTQK KGKISHDKRK KSRSKAIGSD TSDIVHIWCP EGMKTSDIKE
260 270 280 290 300
LNIVLPEFEK THLEHQQRIE SKVCKAAIAT FYVNVKEQFI KMLKESQMLT
310 320 330 340 350
NLKRKNAKMI SDIEKKRQRM IEVQDELLRL EPQLKQLQTK YDELKERKSS
360 370 380 390 400
LRNAAYFLSN LKQLYQDYSD VQAQEPNVKE TYDSSSLPAL LFKARTLLGA
410
ESHLRNINHQ LEKLLDQG
Length:418
Mass (Da):47,522
Last modified:July 5, 2004 - v1
Checksum:iA99BC012EF7188F9
GO
Isoform 2 (identifier: Q71F23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-242: Missing.

Show »
Length:176
Mass (Da):20,710
Checksum:iC5731EE5F7ADCE1D
GO
Isoform 3 (identifier: Q71F23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-337: EPQLKQL → WTGAGLW
     338-418: Missing.

Show »
Length:337
Mass (Da):38,102
Checksum:i24A4BBC85B3E98E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631E → G in AAI07745 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161G → R.
Corresponds to variant rs902174 [ dbSNP | Ensembl ].
VAR_048692
Natural varianti16 – 161G → S.
Corresponds to variant rs902174 [ dbSNP | Ensembl ].
VAR_027144
Natural varianti157 – 1571I → T.
Corresponds to variant rs6552804 [ dbSNP | Ensembl ].
VAR_027145
Natural varianti214 – 2141I → M.
Corresponds to variant rs4616798 [ dbSNP | Ensembl ].
VAR_027146
Natural varianti279 – 2791A → T.
Corresponds to variant rs34007339 [ dbSNP | Ensembl ].
VAR_048693

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 242242Missing in isoform 2. 3 PublicationsVSP_020030Add
BLAST
Alternative sequencei331 – 3377EPQLKQL → WTGAGLW in isoform 3. 1 PublicationVSP_053526
Alternative sequencei338 – 41881Missing in isoform 3. 1 PublicationVSP_053527Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469667 mRNA. Translation: AAQ05290.1.
AF516710 mRNA. Translation: AAQ08228.1.
AK027121 mRNA. Translation: BAB15665.1.
CR457376 mRNA. Translation: CAG33657.1.
DQ907910 mRNA. Translation: ABI49142.1.
AC079257 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04666.1.
BC107744 mRNA. Translation: AAI07745.1.
BC031520 mRNA. Translation: AAH31520.1.
BC131556 mRNA. Translation: AAI31557.1.
CCDSiCCDS3838.1. [Q71F23-1]
RefSeqiNP_078905.2. NM_024629.3. [Q71F23-1]
UniGeneiHs.575032.

Genome annotation databases

EnsembliENST00000281453; ENSP00000281453; ENSG00000151725.
GeneIDi79682.
KEGGihsa:79682.
UCSCiuc003iwq.3. human. [Q71F23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF469667 mRNA. Translation: AAQ05290.1.
AF516710 mRNA. Translation: AAQ08228.1.
AK027121 mRNA. Translation: BAB15665.1.
CR457376 mRNA. Translation: CAG33657.1.
DQ907910 mRNA. Translation: ABI49142.1.
AC079257 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04666.1.
BC107744 mRNA. Translation: AAI07745.1.
BC031520 mRNA. Translation: AAH31520.1.
BC131556 mRNA. Translation: AAI31557.1.
CCDSiCCDS3838.1. [Q71F23-1]
RefSeqiNP_078905.2. NM_024629.3. [Q71F23-1]
UniGeneiHs.575032.

3D structure databases

ProteinModelPortaliQ71F23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122805. 36 interactions.
DIPiDIP-48539N.
IntActiQ71F23. 14 interactions.
MINTiMINT-4992596.
STRINGi9606.ENSP00000281453.

PTM databases

PhosphoSiteiQ71F23.

Polymorphism and mutation databases

BioMutaiMLF1IP.
DMDMi74712714.

Proteomic databases

MaxQBiQ71F23.
PaxDbiQ71F23.
PRIDEiQ71F23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281453; ENSP00000281453; ENSG00000151725.
GeneIDi79682.
KEGGihsa:79682.
UCSCiuc003iwq.3. human. [Q71F23-1]

Organism-specific databases

CTDi79682.
GeneCardsiGC04M185616.
HGNCiHGNC:21348. CENPU.
HPAiHPA022048.
MIMi611511. gene.
neXtProtiNX_Q71F23.
PharmGKBiPA134893791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45595.
GeneTreeiENSGT00390000015511.
HOGENOMiHOG000236255.
HOVERGENiHBG081090.
InParanoidiQ71F23.
KOiK11513.
OMAiKQLHQDY.
OrthoDBiEOG7PS1FG.
PhylomeDBiQ71F23.
TreeFamiTF330780.

Enzyme and pathway databases

ReactomeiREACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_355252. RHO GTPases Activate Formins.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

GeneWikiiMLF1IP.
GenomeRNAii79682.
NextBioi68934.
PROiQ71F23.
SOURCEiSearch...

Gene expression databases

BgeeiQ71F23.
CleanExiHS_MLF1IP.
ExpressionAtlasiQ71F23. baseline and differential.
GenevisibleiQ71F23. HS.

Family and domain databases

InterProiIPR025214. CENP-U.
[Graphical view]
PfamiPF13097. CENP-U. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus."
    Pan H.-Y., Zhang Y.-J., Wang X.-P., Deng J.-H., Zhou F.-C., Gao S.-J.
    J. Virol. 77:9758-9768(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS LATENT NUCLEAR ANTIGEN.
  2. "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP."
    Hanissian S.H., Akbar U., Teng B., Janjetovic Z., Hoffmann A., Hitzler J.K., Iscove N., Hamre K., Du X., Tong Y., Mukatira S., Robertson J.H., Morris S.W.
    Oncogene 23:3700-3707(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MLF1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Role of alternatively spliced MLF1IP isoforms in brain tumor pathogenesis."
    Hanissian S.H.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Glioblastoma.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal cortex and Testis.
  9. "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma."
    Hanissian S.H., Teng B., Akbar U., Janjetovic Z., Zhou Q., Duntsch C., Robertson J.H.
    Brain Res. 1047:56-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells."
    Izuta H., Ikeno M., Suzuki N., Tomonaga T., Nozaki N., Obuse C., Kisu Y., Goshima N., Nomura F., Nomura N., Yoda K.
    Genes Cells 11:673-684(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ AND CENPR.
  12. Cited for: IDENTIFICATION IN THE CENPA-NAC COMPLEX WITH CENPA; CENPC; CENPH; CENPM; CENPN AND CENPT.
  13. "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation."
    Kang Y.H., Park J.-E., Yu L.-R., Soung N.-K., Yun S.-M., Bang J.K., Seong Y.-S., Yu H., Garfield S., Veenstra T.D., Lee K.S.
    Mol. Cell 24:409-422(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PLK1, PHOSPHORYLATION AT THR-78, MUTAGENESIS OF SER-77 AND THR-78.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-110; SER-111; SER-136; SER-139 AND SER-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCENPU_HUMAN
AccessioniPrimary (citable) accession number: Q71F23
Secondary accession number(s): A2RRD9
, Q09GN2, Q32Q71, Q9H5G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.