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Protein

Receptor binding protein

Gene

rbp

Organism
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral attachment to host entry receptor, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor binding protein1 Publication
Short name:
RBP1 Publication
Alternative name(s):
Gene product 18Curated
Short name:
Gp18Curated
Gene namesi
Name:rbpImported
OrganismiLactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Taxonomic identifieri254252 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeSk1virus
Virus hostiLactococcus lactis [TaxID: 1358]
Proteomesi
  • UP000002348 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virus tail, baseplate Source: UniProtKB

Keywords - Cellular componenti

Viral baseplate protein, Viral tail protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004382361 – 264Receptor binding proteinAdd BLAST264

Interactioni

Subunit structurei

Homotrimer; found as an assembly of 6 homotrimers (PubMed:20351260, PubMed:24027307). Interacts with host phosphopolysaccharides; this allows the virus to bind the external cell wall layer (PubMed:16547026, PubMed:20351260, PubMed:24027307). Interacts with the distal tail protein (PubMed:24027307).2 Publications

Protein-protein interaction databases

DIPiDIP-59525N.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi7 – 9Combined sources3
Helixi20 – 31Combined sources12
Beta strandi39 – 44Combined sources6
Beta strandi47 – 49Combined sources3
Beta strandi50 – 62Combined sources13
Beta strandi65 – 75Combined sources11
Beta strandi80 – 88Combined sources9
Beta strandi97 – 104Combined sources8
Turni112 – 114Combined sources3
Beta strandi119 – 128Combined sources10
Beta strandi130 – 138Combined sources9
Beta strandi142 – 144Combined sources3
Beta strandi146 – 157Combined sources12
Beta strandi163 – 171Combined sources9
Beta strandi174 – 181Combined sources8
Turni182 – 184Combined sources3
Beta strandi185 – 194Combined sources10
Helixi210 – 212Combined sources3
Beta strandi218 – 224Combined sources7
Beta strandi230 – 235Combined sources6
Beta strandi241 – 243Combined sources3
Beta strandi253 – 262Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZRUX-ray1.73A/B/C1-264[»]
2BSDX-ray2.30A/B/C1-264[»]
2BSEX-ray2.70A/B/C1-264[»]
2WZPX-ray2.60A/B/C/G/H/I2-264[»]
2X53X-ray3.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-264[»]
3DA0X-ray1.65A/B/C163-264[»]
4V5IX-ray5.46AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL2-264[»]
ProteinModelPortaliQ71AW2.
SMRiQ71AW2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ71AW2.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 264Host receptor binding1 PublicationAdd BLAST101

Domaini

The C-terminus is involved in host receptor binding. Host-recognition domains point upwards, towards the capsid.1 Publication

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR008982. Adenovirus_pIV-rel_att.
IPR015027. Caudo_bapla_RBP.
PfamiView protein in Pfam
PF08931. Caudo_bapla_RBP. 1 hit.
SUPFAMiSSF49835. SSF49835. 1 hit.

Sequencei

Sequence statusi: Complete.

Q71AW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKNFTFFS PNSTEFPVGS NNDGKLYMML TGMDYRTIRR KDWSSPLNTA
60 70 80 90 100
LNVQYTNTSI IAGGRYFELL NETVALKGDS VNYIHANIDL TQTANPVSLS
110 120 130 140 150
AETANNSNGV DINNGSGVLK VCFDIVTTSG TGVTSTKPIV QTSTLDSISV
160 170 180 190 200
NDMTVSGSID VPVQTLTVEA GNGLQLQLTK KNNDLVIVRF FGSVSNIQKG
210 220 230 240 250
WNMSGTWVDR PFRPAAVQSL VGHFAGRDTS FHIDINPNGS ITWWGANIDK
260
TPIATRGNGS YFIK
Length:264
Mass (Da):28,645
Last modified:July 5, 2004 - v1
Checksum:i6D2F7356D7C34853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539441 Genomic DNA. Translation: AAQ10938.1.
GQ979703 Genomic DNA. Translation: AAT81478.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539441 Genomic DNA. Translation: AAQ10938.1.
GQ979703 Genomic DNA. Translation: AAT81478.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZRUX-ray1.73A/B/C1-264[»]
2BSDX-ray2.30A/B/C1-264[»]
2BSEX-ray2.70A/B/C1-264[»]
2WZPX-ray2.60A/B/C/G/H/I2-264[»]
2X53X-ray3.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-264[»]
3DA0X-ray1.65A/B/C163-264[»]
4V5IX-ray5.46AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL2-264[»]
ProteinModelPortaliQ71AW2.
SMRiQ71AW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59525N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ71AW2.

Family and domain databases

InterProiView protein in InterPro
IPR008982. Adenovirus_pIV-rel_att.
IPR015027. Caudo_bapla_RBP.
PfamiView protein in Pfam
PF08931. Caudo_bapla_RBP. 1 hit.
SUPFAMiSSF49835. SSF49835. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRBP_BPLP2
AccessioniPrimary (citable) accession number: Q71AW2
Secondary accession number(s): Q1RNF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.