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Protein

Receptor binding protein

Gene

rbp

Organism
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the host phosphopolysaccharides at the onset of infection. Upon activation by calcium, the receptor binding proteins change their conformation, presenting their binding sites to the host, and a channel opens at the bottom of the baseplate for DNA ejection.2 Publications

GO - Biological processi

  • cell adhesion Source: InterPro
  • viral entry into host cell Source: UniProtKB-KW
  • virion attachment to host cell Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Viral attachment to host entry receptor, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor binding protein1 Publication
Short name:
RBP1 Publication
Alternative name(s):
Gene product 18Curated
Short name:
Gp18Curated
Gene namesi
Name:rbpImported
OrganismiLactococcus phage p2 (Lactococcus lactis bacteriophage p2)
Taxonomic identifieri254252 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridaeSkunalikevirus
Virus hostiLactococcus lactis [TaxID: 1358]
Proteomesi
  • UP000002348 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virus tail, baseplate Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Viral baseplate protein, Viral tail protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004382361 – 264Receptor binding proteinAdd BLAST264

Interactioni

Subunit structurei

Homotrimer; found as an assembly of 6 homotrimers (PubMed:20351260, PubMed:24027307). Interacts with host phosphopolysaccharides; this allows the virus to bind the external cell wall layer (PubMed:16547026, PubMed:20351260, PubMed:24027307). Interacts with the distal tail protein (PubMed:24027307).2 Publications

Protein-protein interaction databases

DIPiDIP-59525N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZRUX-ray1.73A/B/C1-264[»]
2BSDX-ray2.30A/B/C1-264[»]
2BSEX-ray2.70A/B/C1-264[»]
2WZPX-ray2.60A/B/C/G/H/I2-264[»]
2X53X-ray3.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-264[»]
3DA0X-ray1.65A/B/C163-264[»]
4V5IX-ray5.46AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL2-264[»]
ProteinModelPortaliQ71AW2.
SMRiQ71AW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 264Host receptor binding1 PublicationAdd BLAST101

Domaini

The C-terminus is involved in host receptor binding. Host-recognition domains point upwards, towards the capsid.1 Publication

Sequence similaritiesi

Family and domain databases

InterProiIPR008982. Adenovirus_pIV-rel_att.
IPR015027. Caudo_bapla_RBP.
[Graphical view]
PfamiPF08931. Caudo_bapla_RBP. 1 hit.
[Graphical view]
SUPFAMiSSF49835. SSF49835. 1 hit.

Sequencei

Sequence statusi: Complete.

Q71AW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKNFTFFS PNSTEFPVGS NNDGKLYMML TGMDYRTIRR KDWSSPLNTA
60 70 80 90 100
LNVQYTNTSI IAGGRYFELL NETVALKGDS VNYIHANIDL TQTANPVSLS
110 120 130 140 150
AETANNSNGV DINNGSGVLK VCFDIVTTSG TGVTSTKPIV QTSTLDSISV
160 170 180 190 200
NDMTVSGSID VPVQTLTVEA GNGLQLQLTK KNNDLVIVRF FGSVSNIQKG
210 220 230 240 250
WNMSGTWVDR PFRPAAVQSL VGHFAGRDTS FHIDINPNGS ITWWGANIDK
260
TPIATRGNGS YFIK
Length:264
Mass (Da):28,645
Last modified:July 5, 2004 - v1
Checksum:i6D2F7356D7C34853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539441 Genomic DNA. Translation: AAQ10938.1.
GQ979703 Genomic DNA. Translation: AAT81478.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539441 Genomic DNA. Translation: AAQ10938.1.
GQ979703 Genomic DNA. Translation: AAT81478.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZRUX-ray1.73A/B/C1-264[»]
2BSDX-ray2.30A/B/C1-264[»]
2BSEX-ray2.70A/B/C1-264[»]
2WZPX-ray2.60A/B/C/G/H/I2-264[»]
2X53X-ray3.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R2-264[»]
3DA0X-ray1.65A/B/C163-264[»]
4V5IX-ray5.46AA/AB/AC/AD/AE/AF/AG/AH/AI/AJ/AK/AL/AM/AN/AO/AP/AQ/AR/BA/BB/BC/BD/BE/BF/BG/BH/BI/BJ/BK/BL2-264[»]
ProteinModelPortaliQ71AW2.
SMRiQ71AW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59525N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR008982. Adenovirus_pIV-rel_att.
IPR015027. Caudo_bapla_RBP.
[Graphical view]
PfamiPF08931. Caudo_bapla_RBP. 1 hit.
[Graphical view]
SUPFAMiSSF49835. SSF49835. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRBP_BPLP2
AccessioniPrimary (citable) accession number: Q71AW2
Secondary accession number(s): Q1RNF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.