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Protein

Activator of 90 kDa heat shock protein ATPase homolog 2

Gene

AHSA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Co-chaperone that stimulates HSP90 ATPase activity.By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 2
Gene namesi
Name:AHSA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20437. AHSA2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Activator of 90 kDa heat shock protein ATPase homolog 2PRO_0000315605Add
BLAST

Proteomic databases

PaxDbiQ719I0.
PRIDEiQ719I0.

PTM databases

PhosphoSiteiQ719I0.

Expressioni

Gene expression databases

BgeeiQ719I0.
CleanExiHS_AHSA2.
ExpressionAtlasiQ719I0. baseline and differential.
GenevestigatoriQ719I0.

Organism-specific databases

HPAiHPA051137.

Interactioni

Protein-protein interaction databases

BioGridi126261. 2 interactions.
IntActiQ719I0. 2 interactions.
MINTiMINT-4714104.
STRINGi9606.ENSP00000349525.

Structurei

3D structure databases

ProteinModelPortaliQ719I0.
SMRiQ719I0. Positions 23-165, 200-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiNOG289133.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ719I0.
OrthoDBiEOG77DJ64.
PhylomeDBiQ719I0.

Family and domain databases

InterProiIPR015310. AHSA1_N.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q719I0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE
60 70 80 90 100
NDAGRGEINE LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH
110 120 130 140 150
KGLIEIPNLS EENEVDDTEV SLSKKKGDGV ILKDLMKTAG TAKVREALGD
160 170 180 190 200
YLKALKTEFT TGMILPTKAM ATQELTVKRK LSGNTLQVQA SSPVALGVRI
210 220 230 240 250
PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN WPEEHYAMVA
260 270 280 290
LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG
Length:299
Mass (Da):33,806
Last modified:January 14, 2008 - v2
Checksum:iB34F66CAA76CF13F
GO
Isoform 2 (identifier: Q719I0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-157: ALKT → MTLP

Show »
Length:146
Mass (Da):16,679
Checksum:iD63F414F0BAB2594
GO
Isoform 3 (identifier: Q719I0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:137
Mass (Da):15,700
Checksum:i64A029446647049A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti248 – 2481M → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_038256

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 162162Missing in isoform 3. 3 PublicationsVSP_030569Add
BLAST
Alternative sequencei1 – 153153Missing in isoform 2. 1 PublicationVSP_030570Add
BLAST
Alternative sequencei154 – 1574ALKT → MTLP in isoform 2. 1 PublicationVSP_030571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542548 mRNA. Translation: AAQ09531.1.
AK092817 mRNA. Translation: BAG52613.1.
AL833813 mRNA. Translation: CAD38676.1.
AC016747 Genomic DNA. Translation: AAY14686.1.
CH471053 Genomic DNA. Translation: EAX00003.1.
CH471053 Genomic DNA. Translation: EAX00006.1.
CH471053 Genomic DNA. Translation: EAX00008.1.
BC113671 mRNA. Translation: AAI13672.1.
BC117278 mRNA. Translation: AAI17279.1.
CCDSiCCDS1868.1. [Q719I0-3]
RefSeqiNP_689605.1. NM_152392.3. [Q719I0-3]
UniGeneiHs.655602.
Hs.732993.

Genome annotation databases

EnsembliENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
GeneIDi130872.
KEGGihsa:130872.
UCSCiuc002sbb.2. human. [Q719I0-3]

Polymorphism databases

DMDMi166198353.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542548 mRNA. Translation: AAQ09531.1.
AK092817 mRNA. Translation: BAG52613.1.
AL833813 mRNA. Translation: CAD38676.1.
AC016747 Genomic DNA. Translation: AAY14686.1.
CH471053 Genomic DNA. Translation: EAX00003.1.
CH471053 Genomic DNA. Translation: EAX00006.1.
CH471053 Genomic DNA. Translation: EAX00008.1.
BC113671 mRNA. Translation: AAI13672.1.
BC117278 mRNA. Translation: AAI17279.1.
CCDSiCCDS1868.1. [Q719I0-3]
RefSeqiNP_689605.1. NM_152392.3. [Q719I0-3]
UniGeneiHs.655602.
Hs.732993.

3D structure databases

ProteinModelPortaliQ719I0.
SMRiQ719I0. Positions 23-165, 200-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126261. 2 interactions.
IntActiQ719I0. 2 interactions.
MINTiMINT-4714104.
STRINGi9606.ENSP00000349525.

PTM databases

PhosphoSiteiQ719I0.

Polymorphism databases

DMDMi166198353.

Proteomic databases

PaxDbiQ719I0.
PRIDEiQ719I0.

Protocols and materials databases

DNASUi130872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
GeneIDi130872.
KEGGihsa:130872.
UCSCiuc002sbb.2. human. [Q719I0-3]

Organism-specific databases

CTDi130872.
GeneCardsiGC02P061404.
HGNCiHGNC:20437. AHSA2.
HPAiHPA051137.
neXtProtiNX_Q719I0.
PharmGKBiPA134913389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289133.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ719I0.
OrthoDBiEOG77DJ64.
PhylomeDBiQ719I0.

Miscellaneous databases

ChiTaRSiAHSA2. human.
GenomeRNAii130872.
NextBioi82836.
PROiQ719I0.

Gene expression databases

BgeeiQ719I0.
CleanExiHS_AHSA2.
ExpressionAtlasiQ719I0. baseline and differential.
GenevestigatoriQ719I0.

Family and domain databases

InterProiIPR015310. AHSA1_N.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human gene with heat shock hsp90 proteins family signature and phytochrome chromophore attachment site."
    Zhang D.L., Cai J.J., Ma D.L.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  7. Cited for: IDENTIFICATION.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-248.

Entry informationi

Entry nameiAHSA2_HUMAN
AccessioniPrimary (citable) accession number: Q719I0
Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: January 14, 2008
Last modified: March 31, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.