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Q719I0

- AHSA2_HUMAN

UniProt

Q719I0 - AHSA2_HUMAN

Protein

Activator of 90 kDa heat shock protein ATPase homolog 2

Gene

AHSA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Co-chaperone that stimulates HSP90 ATPase activity.By similarity

    GO - Molecular functioni

    1. ATPase activator activity Source: InterPro

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activator of 90 kDa heat shock protein ATPase homolog 2
    Gene namesi
    Name:AHSA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20437. AHSA2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Activator of 90 kDa heat shock protein ATPase homolog 2PRO_0000315605Add
    BLAST

    Proteomic databases

    PaxDbiQ719I0.
    PRIDEiQ719I0.

    PTM databases

    PhosphoSiteiQ719I0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ719I0.
    BgeeiQ719I0.
    CleanExiHS_AHSA2.
    GenevestigatoriQ719I0.

    Organism-specific databases

    HPAiHPA051137.

    Interactioni

    Protein-protein interaction databases

    BioGridi126261. 1 interaction.
    IntActiQ719I0. 2 interactions.
    MINTiMINT-4714104.
    STRINGi9606.ENSP00000349525.

    Structurei

    3D structure databases

    ProteinModelPortaliQ719I0.
    SMRiQ719I0. Positions 200-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AHA1 family.Curated

    Phylogenomic databases

    eggNOGiNOG289133.
    HOGENOMiHOG000242852.
    HOVERGENiHBG065806.
    OrthoDBiEOG77DJ64.
    PhylomeDBiQ719I0.

    Family and domain databases

    InterProiIPR015310. AHSA1_N.
    [Graphical view]
    PfamiPF09229. Aha1_N. 1 hit.
    [Graphical view]
    SMARTiSM01000. Aha1_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF103111. SSF103111. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q719I0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE    50
    NDAGRGEINE LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH 100
    KGLIEIPNLS EENEVDDTEV SLSKKKGDGV ILKDLMKTAG TAKVREALGD 150
    YLKALKTEFT TGMILPTKAM ATQELTVKRK LSGNTLQVQA SSPVALGVRI 200
    PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN WPEEHYAMVA 250
    LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG 299
    Length:299
    Mass (Da):33,806
    Last modified:January 15, 2008 - v2
    Checksum:iB34F66CAA76CF13F
    GO
    Isoform 2 (identifier: Q719I0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.
         154-157: ALKT → MTLP

    Show »
    Length:146
    Mass (Da):16,679
    Checksum:iD63F414F0BAB2594
    GO
    Isoform 3 (identifier: Q719I0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-162: Missing.

    Show »
    Length:137
    Mass (Da):15,700
    Checksum:i64A029446647049A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti248 – 2481M → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_038256

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 162162Missing in isoform 3. 3 PublicationsVSP_030569Add
    BLAST
    Alternative sequencei1 – 153153Missing in isoform 2. 1 PublicationVSP_030570Add
    BLAST
    Alternative sequencei154 – 1574ALKT → MTLP in isoform 2. 1 PublicationVSP_030571

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542548 mRNA. Translation: AAQ09531.1.
    AK092817 mRNA. Translation: BAG52613.1.
    AL833813 mRNA. Translation: CAD38676.1.
    AC016747 Genomic DNA. Translation: AAY14686.1.
    CH471053 Genomic DNA. Translation: EAX00003.1.
    CH471053 Genomic DNA. Translation: EAX00006.1.
    CH471053 Genomic DNA. Translation: EAX00008.1.
    BC113671 mRNA. Translation: AAI13672.1.
    BC117278 mRNA. Translation: AAI17279.1.
    CCDSiCCDS1868.1. [Q719I0-3]
    RefSeqiNP_689605.1. NM_152392.3. [Q719I0-3]
    UniGeneiHs.655602.
    Hs.732993.

    Genome annotation databases

    EnsembliENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
    ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
    GeneIDi130872.
    KEGGihsa:130872.
    UCSCiuc002sbb.2. human. [Q719I0-3]

    Polymorphism databases

    DMDMi166198353.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF542548 mRNA. Translation: AAQ09531.1 .
    AK092817 mRNA. Translation: BAG52613.1 .
    AL833813 mRNA. Translation: CAD38676.1 .
    AC016747 Genomic DNA. Translation: AAY14686.1 .
    CH471053 Genomic DNA. Translation: EAX00003.1 .
    CH471053 Genomic DNA. Translation: EAX00006.1 .
    CH471053 Genomic DNA. Translation: EAX00008.1 .
    BC113671 mRNA. Translation: AAI13672.1 .
    BC117278 mRNA. Translation: AAI17279.1 .
    CCDSi CCDS1868.1. [Q719I0-3 ]
    RefSeqi NP_689605.1. NM_152392.3. [Q719I0-3 ]
    UniGenei Hs.655602.
    Hs.732993.

    3D structure databases

    ProteinModelPortali Q719I0.
    SMRi Q719I0. Positions 200-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126261. 1 interaction.
    IntActi Q719I0. 2 interactions.
    MINTi MINT-4714104.
    STRINGi 9606.ENSP00000349525.

    PTM databases

    PhosphoSitei Q719I0.

    Polymorphism databases

    DMDMi 166198353.

    Proteomic databases

    PaxDbi Q719I0.
    PRIDEi Q719I0.

    Protocols and materials databases

    DNASUi 130872.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357022 ; ENSP00000349525 ; ENSG00000173209 . [Q719I0-3 ]
    ENST00000394457 ; ENSP00000377970 ; ENSG00000173209 . [Q719I0-3 ]
    GeneIDi 130872.
    KEGGi hsa:130872.
    UCSCi uc002sbb.2. human. [Q719I0-3 ]

    Organism-specific databases

    CTDi 130872.
    GeneCardsi GC02P061404.
    HGNCi HGNC:20437. AHSA2.
    HPAi HPA051137.
    neXtProti NX_Q719I0.
    PharmGKBi PA134913389.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289133.
    HOGENOMi HOG000242852.
    HOVERGENi HBG065806.
    OrthoDBi EOG77DJ64.
    PhylomeDBi Q719I0.

    Miscellaneous databases

    ChiTaRSi AHSA2. human.
    GenomeRNAii 130872.
    NextBioi 82836.
    PROi Q719I0.

    Gene expression databases

    ArrayExpressi Q719I0.
    Bgeei Q719I0.
    CleanExi HS_AHSA2.
    Genevestigatori Q719I0.

    Family and domain databases

    InterProi IPR015310. AHSA1_N.
    [Graphical view ]
    Pfami PF09229. Aha1_N. 1 hit.
    [Graphical view ]
    SMARTi SM01000. Aha1_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103111. SSF103111. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human gene with heat shock hsp90 proteins family signature and phytochrome chromophore attachment site."
      Zhang D.L., Cai J.J., Ma D.L.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Small intestine.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    7. Cited for: IDENTIFICATION.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-248.

    Entry informationi

    Entry nameiAHSA2_HUMAN
    AccessioniPrimary (citable) accession number: Q719I0
    Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3