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Protein

Putative activator of 90 kDa heat shock protein ATPase homolog 2

Gene

AHSA2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Co-chaperone that stimulates HSP90 ATPase activity.By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Putative activator of 90 kDa heat shock protein ATPase homolog 2Curated
Alternative name(s):
Activator of HSP90 ATPase homolog 2 pseudogeneImported
Gene namesi
Name:AHSA2PImported
Synonyms:AHSA2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000173209.22
HGNCiHGNC:20437 AHSA2P
neXtProtiNX_Q719I0

Pathology & Biotechi

Organism-specific databases

DisGeNETi130872
OpenTargetsiENSG00000173209
PharmGKBiPA134913389

Polymorphism and mutation databases

DMDMi166198353

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156051 – 299Putative activator of 90 kDa heat shock protein ATPase homolog 2Add BLAST299

Proteomic databases

PaxDbiQ719I0
PeptideAtlasiQ719I0
PRIDEiQ719I0

PTM databases

iPTMnetiQ719I0
PhosphoSitePlusiQ719I0

Expressioni

Gene expression databases

BgeeiENSG00000173209
CleanExiHS_AHSA2
ExpressionAtlasiQ719I0 baseline and differential
GenevisibleiQ719I0 HS

Organism-specific databases

HPAiHPA051137

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-9361704,EBI-748397

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1262612 interactors.
IntActiQ719I0 3 interactors.
STRINGi9606.ENSP00000349525

Structurei

3D structure databases

ProteinModelPortaliQ719I0
SMRiQ719I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiKOG2936 Eukaryota
COG5580 LUCA
GeneTreeiENSGT00390000006429
HOGENOMiHOG000242852
HOVERGENiHBG065806
InParanoidiQ719I0
PhylomeDBiQ719I0

Family and domain databases

Gene3Di3.15.10.201 hit
3.30.530.201 hit
InterProiView protein in InterPro
IPR036338 Aha1
IPR015310 AHSA1_N
IPR023393 START-like_dom_sf
PfamiView protein in Pfam
PF09229 Aha1_N, 1 hit
SMARTiView protein in SMART
SM01000 Aha1_N, 1 hit
SUPFAMiSSF103111 SSF103111, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q719I0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE
60 70 80 90 100
NDAGRGEINE LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH
110 120 130 140 150
KGLIEIPNLS EENEVDDTEV SLSKKKGDGV ILKDLMKTAG TAKVREALGD
160 170 180 190 200
YLKALKTEFT TGMILPTKAM ATQELTVKRK LSGNTLQVQA SSPVALGVRI
210 220 230 240 250
PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN WPEEHYAMVA
260 270 280 290
LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG
Length:299
Mass (Da):33,806
Last modified:January 15, 2008 - v2
Checksum:iB34F66CAA76CF13F
GO
Isoform 2 (identifier: Q719I0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-157: ALKT → MTLP

Show »
Length:146
Mass (Da):16,679
Checksum:iD63F414F0BAB2594
GO
Isoform 3 (identifier: Q719I0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:137
Mass (Da):15,700
Checksum:i64A029446647049A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038256248M → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0305691 – 162Missing in isoform 3. 3 PublicationsAdd BLAST162
Alternative sequenceiVSP_0305701 – 153Missing in isoform 2. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_030571154 – 157ALKT → MTLP in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542548 mRNA Translation: AAQ09531.1
AK092817 mRNA Translation: BAG52613.1
AL833813 mRNA Translation: CAD38676.1
AC016747 Genomic DNA Translation: AAY14686.1
CH471053 Genomic DNA Translation: EAX00003.1
CH471053 Genomic DNA Translation: EAX00006.1
CH471053 Genomic DNA Translation: EAX00008.1
BC113671 mRNA Translation: AAI13672.1
BC117278 mRNA Translation: AAI17279.1
RefSeqiNP_001308229.1, NM_001321300.1
NP_689605.1, NM_152392.4
UniGeneiHs.655602
Hs.732993

Genome annotation databases

EnsembliENST00000357022; ENSP00000349525; ENSG00000173209 [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209 [Q719I0-3]
GeneIDi130872
UCSCiuc002sbb.4 human [Q719I0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAHSA2_HUMAN
AccessioniPrimary (citable) accession number: Q719I0
Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome