Q719I0 (AHSA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 2

Gene names

Name:

AHSA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Co-chaperone that stimulates HSP90 ATPase activity By similarity.
Sequence similarities	Belongs to the AHA1 family.

Ontologies

Keywords
Biological process	Stress response
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of ATPase activity Inferred from electronic annotation. Source: GOC response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATPase activator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q719I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q719I0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-157: ALKT → MTLP

Isoform 3 (identifier: Q719I0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Activator of 90 kDa heat shock protein ATPase homolog 2		PRO_0000315605
Natural variations
	Alternative sequence	1 – 162	162	Missing in isoform 3.		VSP_030569
	Alternative sequence	1 – 153	153	Missing in isoform 2.		VSP_030570
	Alternative sequence	154 – 157	4	ALKT → MTLP in isoform 2.		VSP_030571
	Natural variant	248	1	M → T in a breast cancer sample; somatic mutation. Ref.8		VAR_038256

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: B34F66CAA76CF13F	FASTA	299	33,806
	10 20 30 40 50 60 MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE NDAGRGEINE 70 80 90 100 110 120 LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH KGLIEIPNLS EENEVDDTEV 130 140 150 160 170 180 SLSKKKGDGV ILKDLMKTAG TAKVREALGD YLKALKTEFT TGMILPTKAM ATQELTVKRK 190 200 210 220 230 240 LSGNTLQVQA SSPVALGVRI PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN 250 260 270 280 290 WPEEHYAMVA LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG
	Isoform 2 [UniParc]. Checksum: D63F414F0BAB2594	FASTA	146	16,679
	10 20 30 40 50 60 MTLPEFTTGM ILPTKAMATQ ELTVKRKLSG NTLQVQASSP VALGVRIPTV ALHMMELFDT 70 80 90 100 110 120 TVEQLYSIFT VKELTNKKII MKWRCGNWPE EHYAMVALNF VPTLGQTELQ LKEFLSICKE 130 140 ENMKFCWQKQ HFEEIKGSLQ LTPLNG
	Isoform 3 [UniParc]. Checksum: 64A029446647049A	FASTA	137	15,700
	10 20 30 40 50 60 MILPTKAMAT QELTVKRKLS GNTLQVQASS PVALGVRIPT VALHMMELFD TTVEQLYSIF 70 80 90 100 110 120 TVKELTNKKI IMKWRCGNWP EEHYAMVALN FVPTLGQTEL QLKEFLSICK EENMKFCWQK 130 QHFEEIKGSL QLTPLNG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human gene with heat shock hsp90 proteins family signature and phytochrome chromophore attachment site." Zhang D.L., Cai J.J., Ma D.L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Small intestine.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]	"Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1." Panaretou B., Siligardi G., Meyer P., Maloney A., Sullivan J.K., Singh S., Millson S.H., Clarke P.A., Naaby-Hansen S., Stein R., Cramer R., Mollapour M., Workman P., Piper P.W., Pearl L.H., Prodromou C. Mol. Cell 10:1307-1318(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-248.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF542548 mRNA. Translation: AAQ09531.1. AK092817 mRNA. Translation: BAG52613.1. AL833813 mRNA. Translation: CAD38676.1. AC016747 Genomic DNA. Translation: AAY14686.1. CH471053 Genomic DNA. Translation: EAX00003.1. CH471053 Genomic DNA. Translation: EAX00006.1. CH471053 Genomic DNA. Translation: EAX00008.1. BC113671 mRNA. Translation: AAI13672.1. BC117278 mRNA. Translation: AAI17279.1.
IPI	IPI00168592. IPI00873311. IPI00942660.
RefSeq	NP_689605.1. NM_152392.3.
UniGene	Hs.655602. Hs.732993.
3D structure databases
HSSP	HSSP built from PDB template 1X53 based on UniProtKB O95433.
ProteinModelPortal	Q719I0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000349525.
PTM databases
PhosphoSite	Q719I0.
Polymorphism databases
DMDM	166198353.
Proteomic databases
PaxDb	Q719I0.
PRIDE	Q719I0.
Protocols and materials databases
DNASU	130872.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357022; ENSP00000349525; ENSG00000173209. ENST00000394457; ENSP00000377970; ENSG00000173209.
GeneID	130872.
KEGG	hsa:130872.
UCSC	uc002sbb.2. human.
Organism-specific databases
CTD	130872.
GeneCards	GC02P061404.
HGNC	HGNC:20437. AHSA2.
HPA	HPA051137.
neXtProt	NX_Q719I0.
PharmGKB	PA134913389.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289133.
HOGENOM	HOG000242852.
HOVERGEN	HBG065806.
OrthoDB	EOG4Q84XQ.
Gene expression databases
ArrayExpress	Q719I0.
Bgee	Q719I0.
CleanEx	HS_AHSA2.
Genevestigator	Q719I0.
Family and domain databases
InterPro	IPR015310. AHSA1_N. [Graphical view]
Pfam	PF09229. Aha1_N. 1 hit. [Graphical view]
SMART	SM01000. Aha1_N. 1 hit. [Graphical view]
SUPFAM	SSF103111. AHSA1_N. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	AHSA2. human.
GenomeRNAi	130872.
NextBio	82836.

Entry information

Entry name

AHSA2_HUMAN

Accession

Primary (citable) accession number: Q719I0
Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.