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Q719I0 (AHSA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activator of 90 kDa heat shock protein ATPase homolog 2
Gene names
Name:AHSA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Co-chaperone that stimulates HSP90 ATPase activity By similarity.

Sequence similarities

Belongs to the AHA1 family.

Ontologies

Keywords
   Biological processStress response
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATPase activator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q719I0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q719I0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-157: ALKT → MTLP
Isoform 3 (identifier: Q719I0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Activator of 90 kDa heat shock protein ATPase homolog 2
PRO_0000315605

Natural variations

Alternative sequence1 – 162162Missing in isoform 3.
VSP_030569
Alternative sequence1 – 153153Missing in isoform 2.
VSP_030570
Alternative sequence154 – 1574ALKT → MTLP in isoform 2.
VSP_030571
Natural variant2481M → T in a breast cancer sample; somatic mutation. Ref.8
VAR_038256

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: B34F66CAA76CF13F

FASTA29933,806
        10         20         30         40         50         60 
MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE NDAGRGEINE 

        70         80         90        100        110        120 
LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH KGLIEIPNLS EENEVDDTEV 

       130        140        150        160        170        180 
SLSKKKGDGV ILKDLMKTAG TAKVREALGD YLKALKTEFT TGMILPTKAM ATQELTVKRK 

       190        200        210        220        230        240 
LSGNTLQVQA SSPVALGVRI PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN 

       250        260        270        280        290 
WPEEHYAMVA LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG 

« Hide

Isoform 2 [UniParc].

Checksum: D63F414F0BAB2594
Show »

FASTA14616,679
Isoform 3 [UniParc].

Checksum: 64A029446647049A
Show »

FASTA13715,700

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel human gene with heat shock hsp90 proteins family signature and phytochrome chromophore attachment site."
Zhang D.L., Cai J.J., Ma D.L.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Small intestine.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]"Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1."
Panaretou B., Siligardi G., Meyer P., Maloney A., Sullivan J.K., Singh S., Millson S.H., Clarke P.A., Naaby-Hansen S., Stein R., Cramer R., Mollapour M., Workman P., Piper P.W., Pearl L.H., Prodromou C.
Mol. Cell 10:1307-1318(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-248.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF542548 mRNA. Translation: AAQ09531.1.
AK092817 mRNA. Translation: BAG52613.1.
AL833813 mRNA. Translation: CAD38676.1.
AC016747 Genomic DNA. Translation: AAY14686.1.
CH471053 Genomic DNA. Translation: EAX00003.1.
CH471053 Genomic DNA. Translation: EAX00006.1.
CH471053 Genomic DNA. Translation: EAX00008.1.
BC113671 mRNA. Translation: AAI13672.1.
BC117278 mRNA. Translation: AAI17279.1.
RefSeqNP_689605.1. NM_152392.3.
UniGeneHs.655602.
Hs.732993.

3D structure databases

ProteinModelPortalQ719I0.
SMRQ719I0. Positions 23-165, 200-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126261. 1 interaction.
MINTMINT-4714104.
STRING9606.ENSP00000349525.

PTM databases

PhosphoSiteQ719I0.

Polymorphism databases

DMDM166198353.

Proteomic databases

PaxDbQ719I0.
PRIDEQ719I0.

Protocols and materials databases

DNASU130872.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
GeneID130872.
KEGGhsa:130872.
UCSCuc002sbb.2. human. [Q719I0-3]

Organism-specific databases

CTD130872.
GeneCardsGC02P061404.
HGNCHGNC:20437. AHSA2.
HPAHPA051137.
neXtProtNX_Q719I0.
PharmGKBPA134913389.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289133.
HOGENOMHOG000242852.
HOVERGENHBG065806.
OrthoDBEOG77DJ64.
PhylomeDBQ719I0.

Gene expression databases

ArrayExpressQ719I0.
BgeeQ719I0.
CleanExHS_AHSA2.
GenevestigatorQ719I0.

Family and domain databases

InterProIPR015310. AHSA1_N.
[Graphical view]
PfamPF09229. Aha1_N. 1 hit.
[Graphical view]
SMARTSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMSSF103111. SSF103111. 1 hit.
ProtoNetSearch...

Other

ChiTaRSAHSA2. human.
GenomeRNAi130872.
NextBio82836.
PROQ719I0.

Entry information

Entry nameAHSA2_HUMAN
AccessionPrimary (citable) accession number: Q719I0
Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM