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Protein

Activator of 90 kDa heat shock protein ATPase homolog 2

Gene

AHSA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that stimulates HSP90 ATPase activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of 90 kDa heat shock protein ATPase homolog 2
Gene namesi
Name:AHSA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20437. AHSA2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi130872.
OpenTargetsiENSG00000173209.
PharmGKBiPA134913389.

Polymorphism and mutation databases

DMDMi166198353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156051 – 299Activator of 90 kDa heat shock protein ATPase homolog 2Add BLAST299

Proteomic databases

PaxDbiQ719I0.
PeptideAtlasiQ719I0.
PRIDEiQ719I0.

PTM databases

iPTMnetiQ719I0.
PhosphoSitePlusiQ719I0.

Expressioni

Gene expression databases

BgeeiENSG00000173209.
CleanExiHS_AHSA2.
ExpressionAtlasiQ719I0. baseline and differential.
GenevisibleiQ719I0. HS.

Organism-specific databases

HPAiHPA051137.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-9361704,EBI-10172134

Protein-protein interaction databases

BioGridi126261. 2 interactors.
IntActiQ719I0. 3 interactors.
MINTiMINT-4714104.
STRINGi9606.ENSP00000349525.

Structurei

3D structure databases

ProteinModelPortaliQ719I0.
SMRiQ719I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AHA1 family.Curated

Phylogenomic databases

eggNOGiKOG2936. Eukaryota.
COG5580. LUCA.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ719I0.
PhylomeDBiQ719I0.

Family and domain databases

InterProiIPR015310. AHSA1_N.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q719I0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE
60 70 80 90 100
NDAGRGEINE LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH
110 120 130 140 150
KGLIEIPNLS EENEVDDTEV SLSKKKGDGV ILKDLMKTAG TAKVREALGD
160 170 180 190 200
YLKALKTEFT TGMILPTKAM ATQELTVKRK LSGNTLQVQA SSPVALGVRI
210 220 230 240 250
PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN WPEEHYAMVA
260 270 280 290
LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG
Length:299
Mass (Da):33,806
Last modified:January 15, 2008 - v2
Checksum:iB34F66CAA76CF13F
GO
Isoform 2 (identifier: Q719I0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-157: ALKT → MTLP

Show »
Length:146
Mass (Da):16,679
Checksum:iD63F414F0BAB2594
GO
Isoform 3 (identifier: Q719I0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Show »
Length:137
Mass (Da):15,700
Checksum:i64A029446647049A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038256248M → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0305691 – 162Missing in isoform 3. 3 PublicationsAdd BLAST162
Alternative sequenceiVSP_0305701 – 153Missing in isoform 2. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_030571154 – 157ALKT → MTLP in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542548 mRNA. Translation: AAQ09531.1.
AK092817 mRNA. Translation: BAG52613.1.
AL833813 mRNA. Translation: CAD38676.1.
AC016747 Genomic DNA. Translation: AAY14686.1.
CH471053 Genomic DNA. Translation: EAX00003.1.
CH471053 Genomic DNA. Translation: EAX00006.1.
CH471053 Genomic DNA. Translation: EAX00008.1.
BC113671 mRNA. Translation: AAI13672.1.
BC117278 mRNA. Translation: AAI17279.1.
CCDSiCCDS1868.1. [Q719I0-3]
RefSeqiNP_001308229.1. NM_001321300.1. [Q719I0-3]
NP_689605.1. NM_152392.4. [Q719I0-3]
UniGeneiHs.655602.
Hs.732993.

Genome annotation databases

EnsembliENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
GeneIDi130872.
KEGGihsa:130872.
UCSCiuc002sbb.4. human. [Q719I0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542548 mRNA. Translation: AAQ09531.1.
AK092817 mRNA. Translation: BAG52613.1.
AL833813 mRNA. Translation: CAD38676.1.
AC016747 Genomic DNA. Translation: AAY14686.1.
CH471053 Genomic DNA. Translation: EAX00003.1.
CH471053 Genomic DNA. Translation: EAX00006.1.
CH471053 Genomic DNA. Translation: EAX00008.1.
BC113671 mRNA. Translation: AAI13672.1.
BC117278 mRNA. Translation: AAI17279.1.
CCDSiCCDS1868.1. [Q719I0-3]
RefSeqiNP_001308229.1. NM_001321300.1. [Q719I0-3]
NP_689605.1. NM_152392.4. [Q719I0-3]
UniGeneiHs.655602.
Hs.732993.

3D structure databases

ProteinModelPortaliQ719I0.
SMRiQ719I0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126261. 2 interactors.
IntActiQ719I0. 3 interactors.
MINTiMINT-4714104.
STRINGi9606.ENSP00000349525.

PTM databases

iPTMnetiQ719I0.
PhosphoSitePlusiQ719I0.

Polymorphism and mutation databases

DMDMi166198353.

Proteomic databases

PaxDbiQ719I0.
PeptideAtlasiQ719I0.
PRIDEiQ719I0.

Protocols and materials databases

DNASUi130872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357022; ENSP00000349525; ENSG00000173209. [Q719I0-3]
ENST00000394457; ENSP00000377970; ENSG00000173209. [Q719I0-3]
GeneIDi130872.
KEGGihsa:130872.
UCSCiuc002sbb.4. human. [Q719I0-1]

Organism-specific databases

CTDi130872.
DisGeNETi130872.
GeneCardsiAHSA2.
HGNCiHGNC:20437. AHSA2.
HPAiHPA051137.
neXtProtiNX_Q719I0.
OpenTargetsiENSG00000173209.
PharmGKBiPA134913389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2936. Eukaryota.
COG5580. LUCA.
GeneTreeiENSGT00390000006429.
HOGENOMiHOG000242852.
HOVERGENiHBG065806.
InParanoidiQ719I0.
PhylomeDBiQ719I0.

Miscellaneous databases

ChiTaRSiAHSA2. human.
GenomeRNAii130872.
PROiQ719I0.

Gene expression databases

BgeeiENSG00000173209.
CleanExiHS_AHSA2.
ExpressionAtlasiQ719I0. baseline and differential.
GenevisibleiQ719I0. HS.

Family and domain databases

InterProiIPR015310. AHSA1_N.
[Graphical view]
PfamiPF09229. Aha1_N. 1 hit.
[Graphical view]
SMARTiSM01000. Aha1_N. 1 hit.
[Graphical view]
SUPFAMiSSF103111. SSF103111. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAHSA2_HUMAN
AccessioniPrimary (citable) accession number: Q719I0
Secondary accession number(s): B3KS51, D6W5E0, Q8NDU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.