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Protein

cAMP-regulated phosphoprotein 19

Gene

ARPP19

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-SSC-2029482. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:ARPP19
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002359872 – 112cAMP-regulated phosphoprotein 19Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei62Phosphoserine; by GWLBy similarity1
Modified residuei104Phosphoserine; by PKABy similarity1
Modified residuei109N6-acetyllysineBy similarity1
Isoform ARPP-16 (identifier: Q712U6-2)
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ712U6.
PeptideAtlasiQ712U6.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSSSCG00000004618.
ExpressionAtlasiQ712U6. differential.
GenevisibleiQ712U6. SS.

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004976.

Structurei

3D structure databases

ProteinModelPortaliQ712U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076. Eukaryota.
ENOG4112586. LUCA.
GeneTreeiENSGT00910000144332.
HOGENOMiHOG000232115.
HOVERGENiHBG000297.
InParanoidiQ712U6.
OMAiNEMEDKV.
OrthoDBiEOG091G14MO.
TreeFamiTF314718.

Family and domain databases

InterProiView protein in InterPro
IPR006760. Endosulphine.
PANTHERiPTHR10358. PTHR10358. 1 hit.
PfamiView protein in Pfam
PF04667. Endosulfine. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ARPP-19 (identifier: Q712U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPTA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,323
Last modified:January 23, 2007 - v3
Checksum:iF19652B545C839AB
GO
Isoform ARPP-16 (identifier: Q712U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:96
Mass (Da):10,635
Checksum:iE29FF03CFF5DB609
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185571 – 16Missing in isoform ARPP-16. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005981 mRNA. Translation: CAA06795.1.
RefSeqiNP_999340.1. NM_214175.1. [Q712U6-1]
XP_005659645.1. XM_005659588.2. [Q712U6-1]
XP_005659646.1. XM_005659589.2. [Q712U6-1]
UniGeneiSsc.16084.

Genome annotation databases

EnsembliENSSSCT00000005100; ENSSSCP00000004976; ENSSSCG00000004620. [Q712U6-1]
ENSSSCT00000038541; ENSSSCP00000051686; ENSSSCG00000004620. [Q712U6-1]
ENSSSCT00000038556; ENSSSCP00000035248; ENSSSCG00000004620. [Q712U6-2]
GeneIDi397362.
KEGGissc:397362.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP19_PIG
AccessioniPrimary (citable) accession number: Q712U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome