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Protein

cAMP-regulated phosphoprotein 19

Gene

Arpp19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2465910. MASTL Facilitates Mitotic Progression.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:Arpp19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi71054. Arpp19.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002359882 – 112cAMP-regulated phosphoprotein 19Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei23PhosphoserineBy similarity1
Modified residuei62Phosphoserine; by GWLCurated1
Modified residuei104Phosphoserine; by PKA1 Publication1
Modified residuei109N6-acetyllysineBy similarity1
Isoform ARPP-16 (identifier: Q712U5-2)
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ712U5.
PRIDEiQ712U5.

PTM databases

iPTMnetiQ712U5.
PhosphoSitePlusiQ712U5.

Expressioni

Tissue specificityi

Whereas isoform ARPP-19 is ubiquitously expressed, isoform ARPP-16 is found only in selected brain neurons.1 Publication

Inductioni

Up-regulated in denervated skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000023086.
GenevisibleiQ712U5. RN.

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028470.

Chemistry databases

BindingDBiQ712U5.

Structurei

3D structure databases

ProteinModelPortaliQ712U5.
SMRiQ712U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076. Eukaryota.
ENOG4112586. LUCA.
GeneTreeiENSGT00390000010139.
HOGENOMiHOG000232115.
HOVERGENiHBG000297.
InParanoidiQ712U5.
OMAiNEMEDKV.
OrthoDBiEOG091G14MO.
PhylomeDBiQ712U5.

Family and domain databases

InterProiView protein in InterPro
IPR006760. Endosulphine.
PfamiView protein in Pfam
PF04667. Endosulfine. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ARPP-19 (identifier: Q712U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPAA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,293
Last modified:January 23, 2007 - v3
Checksum:iF18BE46E35C839AB
GO
Isoform ARPP-16 (identifier: Q712U5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:96
Mass (Da):10,605
Checksum:iE28246E78F5DB609
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185581 – 16Missing in isoform ARPP-16. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005982 mRNA. Translation: CAA06796.1.
BC058461 mRNA. Translation: AAH58461.1.
RefSeqiNP_113848.1. NM_031660.1. [Q712U5-1]
XP_002727150.2. XM_002727104.4. [Q712U5-1]
XP_002730018.2. XM_002729972.4. [Q712U5-1]
UniGeneiRn.112577.

Genome annotation databases

EnsembliENSRNOT00000030221; ENSRNOP00000035534; ENSRNOG00000023086. [Q712U5-1]
GeneIDi100360828.
60336.
KEGGirno:100360828.
rno:60336.
UCSCiRGD:71054. rat. [Q712U5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP19_RAT
AccessioniPrimary (citable) accession number: Q712U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families