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Protein

cAMP-regulated phosphoprotein 19

Gene

Arpp19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-2465910. MASTL Facilitates Mitotic Progression.

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:Arpp19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi71054. Arpp19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2170.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 112111cAMP-regulated phosphoprotein 19PRO_0000235988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine; in isoform ARPP-19By similarity
Modified residuei2 – 21PhosphoserineCombined sources
Modified residuei17 – 171N-acetylmethionine; in isoform ARPP-16By similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei62 – 621Phosphoserine; by GWLCurated
Modified residuei104 – 1041Phosphoserine; by PKA1 Publication
Modified residuei109 – 1091N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ712U5.
PRIDEiQ712U5.

PTM databases

iPTMnetiQ712U5.
PhosphoSiteiQ712U5.

Expressioni

Tissue specificityi

Whereas isoform ARPP-19 is ubiquitously expressed, isoform ARPP-16 is found only in selected brain neurons.1 Publication

Inductioni

Up-regulated in denervated skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000020977.
GenevisibleiQ712U5. RN.

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028470.

Chemistry

BindingDBiQ712U5.

Structurei

3D structure databases

ProteinModelPortaliQ712U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076. Eukaryota.
ENOG4112586. LUCA.
GeneTreeiENSGT00390000010139.
HOGENOMiHOG000232115.
HOVERGENiHBG000297.
InParanoidiQ712U5.
OMAiNKFPTTS.
OrthoDBiEOG091G14MO.
PhylomeDBiQ712U5.

Family and domain databases

InterProiIPR006760. Endosulphine.
[Graphical view]
PfamiPF04667. Endosulfine. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ARPP-19 (identifier: Q712U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPAA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,293
Last modified:January 23, 2007 - v3
Checksum:iF18BE46E35C839AB
GO
Isoform ARPP-16 (identifier: Q712U5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:96
Mass (Da):10,605
Checksum:iE28246E78F5DB609
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616Missing in isoform ARPP-16. CuratedVSP_018558Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005982 mRNA. Translation: CAA06796.1.
BC058461 mRNA. Translation: AAH58461.1.
RefSeqiNP_113848.1. NM_031660.1. [Q712U5-1]
XP_002727150.2. XM_002727104.4. [Q712U5-1]
XP_002730018.2. XM_002729972.4. [Q712U5-1]
UniGeneiRn.112577.

Genome annotation databases

EnsembliENSRNOT00000030221; ENSRNOP00000035534; ENSRNOG00000023086. [Q712U5-1]
GeneIDi100360828.
60336.
KEGGirno:100360828.
rno:60336.
UCSCiRGD:71054. rat. [Q712U5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005982 mRNA. Translation: CAA06796.1.
BC058461 mRNA. Translation: AAH58461.1.
RefSeqiNP_113848.1. NM_031660.1. [Q712U5-1]
XP_002727150.2. XM_002727104.4. [Q712U5-1]
XP_002730018.2. XM_002729972.4. [Q712U5-1]
UniGeneiRn.112577.

3D structure databases

ProteinModelPortaliQ712U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028470.

Chemistry

BindingDBiQ712U5.
ChEMBLiCHEMBL2170.

PTM databases

iPTMnetiQ712U5.
PhosphoSiteiQ712U5.

Proteomic databases

PaxDbiQ712U5.
PRIDEiQ712U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030221; ENSRNOP00000035534; ENSRNOG00000023086. [Q712U5-1]
GeneIDi100360828.
60336.
KEGGirno:100360828.
rno:60336.
UCSCiRGD:71054. rat. [Q712U5-1]

Organism-specific databases

CTDi10776.
RGDi71054. Arpp19.

Phylogenomic databases

eggNOGiKOG4076. Eukaryota.
ENOG4112586. LUCA.
GeneTreeiENSGT00390000010139.
HOGENOMiHOG000232115.
HOVERGENiHBG000297.
InParanoidiQ712U5.
OMAiNKFPTTS.
OrthoDBiEOG091G14MO.
PhylomeDBiQ712U5.

Enzyme and pathway databases

ReactomeiR-RNO-2465910. MASTL Facilitates Mitotic Progression.

Miscellaneous databases

PROiQ712U5.

Gene expression databases

BgeeiENSRNOG00000020977.
GenevisibleiQ712U5. RN.

Family and domain databases

InterProiIPR006760. Endosulphine.
[Graphical view]
PfamiPF04667. Endosulfine. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARP19_RAT
AccessioniPrimary (citable) accession number: Q712U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.