Q712N7 (Q712N7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Caveolin RuleBase RU000680

Gene names

Name:

caveolin-2 EMBL CAB36907.1

Organism

Homo sapiens (Human) EMBL CAB36907.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	21 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. RuleBase RU000680
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane › caveola; Peripheral membrane protein By similarity RuleBase RU000680.
Sequence similarities	Belongs to the caveolin family. RuleBase RU000680

Ontologies

Keywords
Cellular component	Cell membrane RuleBase RU000680 Golgi apparatus RuleBase RU000680 Membrane
Gene Ontology (GO)
Biological_process	endoplasmic reticulum organization Inferred from electronic annotation. Source: Compara mitochondrion organization Inferred from electronic annotation. Source: Compara negative regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara protein oligomerization Inferred from electronic annotation. Source: Compara skeletal muscle fiber development Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell acrosomal membrane Inferred from electronic annotation. Source: Compara caveola Inferred from electronic annotation. Source: UniProtKB-SubCell cell surface Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara lipid particle Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAB36907.1
	Non-terminal residue	21	1	EMBL CAB36907.1

Sequences

	Sequence		Length	Mass (Da)
	Q712N7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4AC6FC4BB5C265E4	FASTA	21	2,373
	10 20 PHRLNSHLKL GFEDVIAEPV T

References

[1]	"Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors." Fra A.M., Mastroianni N., Mancini M., Pasqualetto E., Sitia R. Genomics 56:355-356(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011300 Genomic DNA. Translation: CAB36907.1.
IPI	IPI00759514.
UniGene	Hs.212332. Hs.603096.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000036550.
Gene expression databases
ArrayExpress	Q712N7.
Bgee	Q712N7.
Family and domain databases
InterPro	IPR001612. Caveolin. IPR018361. Caveolin_CS. [Graphical view]
Pfam	PF01146. Caveolin. 1 hit. [Graphical view]
PROSITE	PS01210. CAVEOLIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q712N7_HUMAN

Accession

Primary (citable) accession number: Q712N7

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.