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Q712N7

- Q712N7_HUMAN

UniProt

Q712N7 - Q712N7_HUMAN

Protein

Caveolin

Gene

caveolin-2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.UniRule annotation

    GO - Biological processi

    1. endoplasmic reticulum organization Source: Ensembl
    2. mitochondrion organization Source: Ensembl
    3. negative regulation of endothelial cell proliferation Source: Ensembl
    4. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    5. positive regulation of endothelial cell proliferation Source: Ensembl
    6. protein oligomerization Source: Ensembl
    7. skeletal muscle fiber development Source: Ensembl
    8. synaptic transmission Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CaveolinUniRule annotation
    Gene namesi
    Name:caveolin-2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Golgi apparatus membrane UniRule annotation; Peripheral membrane protein UniRule annotation. Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation. Membranecaveola UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. caveola Source: UniProtKB-SubCell
    3. cell surface Source: Ensembl
    4. cytosol Source: Ensembl
    5. Golgi membrane Source: UniProtKB-SubCell
    6. lipid particle Source: Ensembl
    7. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Golgi apparatusUniRule annotation, Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ712N7.
    BgeeiQ712N7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the caveolin family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036550.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q712N7-1 [UniParc]FASTAAdd to Basket

    « Hide

    PHRLNSHLKL GFEDVIAEPV T                                  21
    Length:21
    Mass (Da):2,373
    Last modified:July 5, 2004 - v1
    Checksum:i4AC6FC4BB5C265E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei21 – 211Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011300 Genomic DNA. Translation: CAB36907.1.
    UniGeneiHs.212332.
    Hs.603096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011300 Genomic DNA. Translation: CAB36907.1 .
    UniGenei Hs.212332.
    Hs.603096.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000036550.

    Gene expression databases

    ArrayExpressi Q712N7.
    Bgeei Q712N7.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors."
      Fra A.M., Mastroianni N., Mancini M., Pasqualetto E., Sitia R.
      Genomics 56:355-356(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ712N7_HUMAN
    AccessioniPrimary (citable) accession number: Q712N7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.