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Q712N7

- Q712N7_HUMAN

UniProt

Q712N7 - Q712N7_HUMAN

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Protein

Caveolin

Gene
caveolin-2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity.UniRule annotation

GO - Biological processi

  1. endoplasmic reticulum organization Source: Ensembl
  2. mitochondrion organization Source: Ensembl
  3. negative regulation of endothelial cell proliferation Source: Ensembl
  4. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  5. positive regulation of endothelial cell proliferation Source: Ensembl
  6. protein oligomerization Source: Ensembl
  7. skeletal muscle fiber development Source: Ensembl
  8. synaptic transmission Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CaveolinUniRule annotation
Gene namesi
Name:caveolin-2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. acrosomal membrane Source: Ensembl
  2. caveola Source: UniProtKB-SubCell
  3. cell surface Source: Ensembl
  4. cytosol Source: Ensembl
  5. Golgi membrane Source: UniProtKB-SubCell
  6. lipid particle Source: Ensembl
  7. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Golgi apparatusUniRule annotation, Membrane

Expressioni

Gene expression databases

ArrayExpressiQ712N7.
BgeeiQ712N7.

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036550.

Family and domain databases

InterProiIPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view]
PfamiPF01146. Caveolin. 1 hit.
[Graphical view]
PROSITEiPS01210. CAVEOLIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q712N7-1 [UniParc]FASTAAdd to Basket

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PHRLNSHLKL GFEDVIAEPV T                                  21
Length:21
Mass (Da):2,373
Last modified:July 5, 2004 - v1
Checksum:i4AC6FC4BB5C265E4
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei21 – 211Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011300 Genomic DNA. Translation: CAB36907.1.
UniGeneiHs.212332.
Hs.603096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011300 Genomic DNA. Translation: CAB36907.1 .
UniGenei Hs.212332.
Hs.603096.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000036550.

Gene expression databases

ArrayExpressi Q712N7.
Bgeei Q712N7.

Family and domain databases

InterProi IPR001612. Caveolin.
IPR018361. Caveolin_CS.
[Graphical view ]
Pfami PF01146. Caveolin. 1 hit.
[Graphical view ]
PROSITEi PS01210. CAVEOLIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors."
    Fra A.M., Mastroianni N., Mancini M., Pasqualetto E., Sitia R.
    Genomics 56:355-356(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ712N7_HUMAN
AccessioniPrimary (citable) accession number: Q712N7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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