Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q711P4

- CCL4_PIG

UniProt

Q711P4 - CCL4_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_226269. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
Small-inducible cytokine A4
Gene namesi
Name:CCL4
Synonyms:MIP1B, SCY4A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 12

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 9269C-C motif chemokine 4PRO_0000326238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer. Interacts with CCR5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000018754.

Structurei

3D structure databases

ProteinModelPortaliQ711P4.
SMRiQ711P4. Positions 24-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG124416.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ711P4.
KOiK12964.
OMAiLRKIPRN.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q711P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTSCCFTYTV RKLPRNFVTD
60 70 80 90
YYETSSLCSQ PAVVFQTKKG RQVCANPSDD WVQEYMDDLE LN
Length:92
Mass (Da):10,207
Last modified:July 5, 2004 - v1
Checksum:iAB1E0AE5EA9F70E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311717 mRNA. Translation: CAC84398.1.
RefSeqiNP_998944.1. NM_213779.1.
UniGeneiSsc.23797.

Genome annotation databases

EnsembliENSSSCT00000019264; ENSSSCP00000018754; ENSSSCG00000017698.
GeneIDi396668.
KEGGissc:396668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311717 mRNA. Translation: CAC84398.1 .
RefSeqi NP_998944.1. NM_213779.1.
UniGenei Ssc.23797.

3D structure databases

ProteinModelPortali Q711P4.
SMRi Q711P4. Positions 24-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000018754.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000019264 ; ENSSSCP00000018754 ; ENSSSCG00000017698 .
GeneIDi 396668.
KEGGi ssc:396668.

Organism-specific databases

CTDi 6351.

Phylogenomic databases

eggNOGi NOG124416.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q711P4.
KOi K12964.
OMAi LRKIPRN.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Enzyme and pathway databases

Reactomei REACT_226269. Chemokine receptors bind chemokines.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning an characterization of the porcine homologous to human chemokine MIP-1beta."
    Ortuno E., Rodriguez-Carreno M.P., Alonso F., Dominguez J., Ezquerra A.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL4_PIG
AccessioniPrimary (citable) accession number: Q711P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3