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Q711P4

- CCL4_PIG

UniProt

Q711P4 - CCL4_PIG

Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4
    Alternative name(s):
    Macrophage inflammatory protein 1-beta
    Short name:
    MIP-1-beta
    Small-inducible cytokine A4
    Gene namesi
    Name:CCL4
    Synonyms:MIP1B, SCY4A
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 12

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 9269C-C motif chemokine 4PRO_0000326238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Gene expression databases

    ArrayExpressiQ711P4.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CCR5 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000018754.

    Structurei

    3D structure databases

    ProteinModelPortaliQ711P4.
    SMRiQ711P4. Positions 24-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG124416.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK12964.
    OMAiLRKIPRN.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q711P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTSCCFTYTV RKLPRNFVTD   50
    YYETSSLCSQ PAVVFQTKKG RQVCANPSDD WVQEYMDDLE LN 92
    Length:92
    Mass (Da):10,207
    Last modified:July 5, 2004 - v1
    Checksum:iAB1E0AE5EA9F70E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311717 mRNA. Translation: CAC84398.1.
    RefSeqiNP_998944.1. NM_213779.1.
    UniGeneiSsc.23797.

    Genome annotation databases

    EnsembliENSSSCT00000019264; ENSSSCP00000018754; ENSSSCG00000017698.
    GeneIDi396668.
    KEGGissc:396668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311717 mRNA. Translation: CAC84398.1 .
    RefSeqi NP_998944.1. NM_213779.1.
    UniGenei Ssc.23797.

    3D structure databases

    ProteinModelPortali Q711P4.
    SMRi Q711P4. Positions 24-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000018754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000019264 ; ENSSSCP00000018754 ; ENSSSCG00000017698 .
    GeneIDi 396668.
    KEGGi ssc:396668.

    Organism-specific databases

    CTDi 6351.

    Phylogenomic databases

    eggNOGi NOG124416.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K12964.
    OMAi LRKIPRN.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Gene expression databases

    ArrayExpressi Q711P4.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning an characterization of the porcine homologous to human chemokine MIP-1beta."
      Ortuno E., Rodriguez-Carreno M.P., Alonso F., Dominguez J., Ezquerra A.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL4_PIG
    AccessioniPrimary (citable) accession number: Q711P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3