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Q711P4 (CCL4_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 4
Alternative name(s):
Macrophage inflammatory protein 1-beta
Short name=MIP-1-beta
Small-inducible cytokine A4
Gene names
Name:CCL4
Synonyms:MIP1B, SCY4A
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties By similarity.

Subunit structure

Homodimer. Interacts with CCR5 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 9269C-C motif chemokine 4
PRO_0000326238

Amino acid modifications

Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q711P4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AB1E0AE5EA9F70E5

FASTA9210,207
        10         20         30         40         50         60 
MKLCVTVLSL LVLVAAFCSP ALSAPMGSDP PTSCCFTYTV RKLPRNFVTD YYETSSLCSQ 

        70         80         90 
PAVVFQTKKG RQVCANPSDD WVQEYMDDLE LN 

« Hide

References

[1]"Cloning an characterization of the porcine homologous to human chemokine MIP-1beta."
Ortuno E., Rodriguez-Carreno M.P., Alonso F., Dominguez J., Ezquerra A.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ311717 mRNA. Translation: CAC84398.1.
RefSeqNP_998944.1. NM_213779.1.
UniGeneSsc.23797.

3D structure databases

ProteinModelPortalQ711P4.
SMRQ711P4. Positions 24-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000018754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000019264; ENSSSCP00000018754; ENSSSCG00000017698.
GeneID396668.
KEGGssc:396668.

Organism-specific databases

CTD6351.

Phylogenomic databases

eggNOGNOG124416.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
KOK12964.
OMALRKIPRN.
OrthoDBEOG7CVQ1F.
TreeFamTF334888.

Gene expression databases

ArrayExpressQ711P4.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCL4_PIG
AccessionPrimary (citable) accession number: Q711P4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families