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Protein

Glucose-6-phosphate isomerase

Gene

gpi1

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpi1)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Proton donorBy similarity1
Active sitei391By similarity1
Active sitei516By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:gpi1
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805691 – 551Glucose-6-phosphate isomeraseAdd BLAST551

Proteomic databases

PRIDEiQ711G1.

Structurei

3D structure databases

ProteinModelPortaliQ711G1.
SMRiQ711G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q711G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSLASNYA SWKQLQEIYD KDRAKIVLRD LFAADPQRFS KLSATYNSQS
60 70 80 90 100
GPGVQILLDY SKHLVTEPIL QKLFNLLREA KVEDARDKMF SGEHINTSED
110 120 130 140 150
RAVLHVALRN FNDFSIKEEG VDEVSKVLQH MKEFSESVRS GQWKGYTGKT
160 170 180 190 200
INTIVNIGIG GSDLGPVMVT EALKPFSKRD LNAHFVSNID GTHIAETLRL
210 220 230 240 250
CDPERTLFIV ASKTFTTQET ITNAESARDW FLGFAKDKAH VAKHFVALST
260 270 280 290 300
NTSAVTAFGI SEANMFQFWD WVGGRYSLWS AIGLSIALVI GFDNFEKLLR
310 320 330 340 350
GAHAMDQHFK TTPLEKNLPA IMAALGIWCN DFYGAQTLAL LPYDQYLHKF
360 370 380 390 400
ADYFQQGDME SNGKFITKNG DRVNYQTGPI IWGASGTNGQ HSFYQLIHQG
410 420 430 440 450
TKIIPADFMA PATSHNPIAN SKHHRILLSN FFAQPEALAF GKTEEEVRKE
460 470 480 490 500
LGQNASEALV KSKVFEGNRP SSSLMFDKLD PATLGALIAL YEHKIFVQGV
510 520 530 540 550
VWGINSFDQM GVELGKVLAK QILAQLDKSD DVKGHDSSVR HLPFILQVDH

C
Length:551
Mass (Da):61,446
Last modified:July 5, 2004 - v1
Checksum:i3747B1A074021671
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ345056 Genomic DNA. Translation: CAC87889.1.

Similar proteinsi

Entry informationi

Entry nameiG6PI_AGABI
AccessioniPrimary (citable) accession number: Q711G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families