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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:HMGN2
Synonyms:HMG17
ORF Names:V2.22
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei82 – 821N6-acetyllysine; alternateBy similarity
Cross-linki82 – 82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ711A6.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030733.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ711A6.
KOiK11300.
OMAiDVKASHE.
OrthoDBiEOG7HTHMK.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q711A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAEGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKDGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,379
Last modified:January 23, 2007 - v3
Checksum:iB1C49E43200422C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388518 mRNA. Translation: CAB46820.1.
RefSeqiNP_001003101.1. NM_001003101.2.
UniGeneiCfa.36589.

Genome annotation databases

EnsembliENSCAFT00000014006; ENSCAFP00000030733; ENSCAFG00000023168.
GeneIDi403686.
KEGGicfa:403686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ388518 mRNA. Translation: CAB46820.1.
RefSeqiNP_001003101.1. NM_001003101.2.
UniGeneiCfa.36589.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000030733.

Proteomic databases

PaxDbiQ711A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000014006; ENSCAFP00000030733; ENSCAFG00000023168.
GeneIDi403686.
KEGGicfa:403686.

Organism-specific databases

CTDi3151.

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiQ711A6.
KOiK11300.
OMAiDVKASHE.
OrthoDBiEOG7HTHMK.

Miscellaneous databases

NextBioi20817190.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis."
    Pichon B., Mercan D., Pouillon V., Christophe-Hobertus C., Christophe D.
    Anal. Biochem. 284:231-239(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION.
    Tissue: Thyroid.

Entry informationi

Entry nameiHMGN2_CANLF
AccessioniPrimary (citable) accession number: Q711A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.