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Protein

SUN domain-containing ossification factor

Gene

Suco

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
SUN domain-containing ossification factor
Alternative name(s):
Membrane protein CH1
Protein osteopotentia homolog
SUN-like protein 1
Gene namesi
Name:Suco
Synonyms:Dd25, Opt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735185. Suco.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1012 – 103221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 12531234SUN domain-containing ossification factorPRO_0000302719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis
Glycosylationi929 – 9291N-linked (GlcNAc...)Sequence analysis
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ710E6.
PRIDEiQ710E6.

PTM databases

iPTMnetiQ710E6.
PhosphoSiteiQ710E6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033216.

Structurei

3D structure databases

ProteinModelPortaliQ710E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini284 – 453170SUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili910 – 1010101Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1396. Eukaryota.
ENOG41116S0. LUCA.
HOVERGENiHBG107549.
InParanoidiQ710E6.
PhylomeDBiQ710E6.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR012919. SUN_dom.
[Graphical view]
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q710E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYRRALAL VSCLSLCSLV WLPSWHVCCK ESSSASTSYY SQDDNCAVGS
60 70 80 90 100
EDIQFQKKNE REEPSNAKVS EKSNSYLTIS PEENKLKDDY TVDECKIWKQ
110 120 130 140 150
SKLSLPVVEA LPTVDSHEES SSVVVGSENI ENSSSSSTSE TSPISKLDEI
160 170 180 190 200
ENSGTLSVAK PGDTEQPEAD CDAGEAADAD ASVEQPAFVS APESLVGQHI
210 220 230 240 250
ENVSSSHGKE KVTKSEFESK VSVSEQDGGD PKSALNASDT LKNESSDYTK
260 270 280 290 300
PRETDPTSVT SPKDPEDIPT FDEWKKKVME VEKEKSQSLH PSSNGGPHAT
310 320 330 340 350
KKVQKNRNNY ASVECGAKIL AANPEAKSTS AILIENMDLY MLNPCSTKIW
360 370 380 390 400
FVIELCEPIQ VKQFDIANYE LFSSTPKDFL VSISDRYPTN KWIKLGTFHG
410 420 430 440 450
RDERTVQSFP LDEQMYAKYV KMFIKYIKVE LLSHFGSEHF CPLSLIRVFG
460 470 480 490 500
TSMVEEYEEI ADSQYQSERQ ELFDEDYDYP LDYNTVEDKS SKNLLGSATN
510 520 530 540 550
AILNMVNIAA NILGAKTEDL TEGDKSISEN ATATTEPKMP ESTGVSTPVP
560 570 580 590 600
SPEYIIKEVH THDTEPPTSD PPKESPIVQL VQEEEEEASP STVTLLGSGE
610 620 630 640 650
QEDESSSWFE SETQILCSEL TSICCISSFS EYLYKWCSVR IALYRQHSRT
660 670 680 690 700
VSKGKDVSPQ PSLLPPVDSV EVSVLQPPSG NVDKEDMERE LETVALDDLS
710 720 730 740 750
SVHQAHVRNH TVDTVELEPS YPQTLSQSLP LDVTPEMDSL STVEGSESVK
760 770 780 790 800
SEGGHKPSQV MPQESSVEFD DETEKKPESF SSVAKLSVIY ETSKVNEVMD
810 820 830 840 850
GPVKEDIVST HVVTKFPETK FPETVAPPPI NTAAVPESEG METKPSLADT
860 870 880 890 900
LKHVVTPVTD PSLPEVKEDE QSPDDALLRG LQRTATDFYA ELQNSTDLGY
910 920 930 940 950
GNGNLVHGSN QKESVFMRLN NRIKALEVNM SLSGRYLEEL SQRYRKQMEE
960 970 980 990 1000
MQKAFNKTIV KLQNTSRIAE EQDQRQTEAI HLLQAQLTNM TQIVSNLSAT
1010 1020 1030 1040 1050
VAELKREVSD RQSYLVMSLV LCVVLGLMLC MQRCRNTSQF DGDYTSKLPK
1060 1070 1080 1090 1100
SNQYPSPKRC FSSYDDMNLK RRTSFPLIRS KSLQFTGKED PNDLYIVEPL
1110 1120 1130 1140 1150
KFSPEKKKKR CKYKTEKIET IKPADPLHPI ANGDIKGRKP FTNQRDFSSM
1160 1170 1180 1190 1200
GEVYHSSYKG PPSEGSSETS SQSEESYFCG ISACTSLCNG QTQKTKLRRG
1210 1220 1230 1240 1250
LKRRRSKVQD QGKLIKALIQ TKSGSLPSLH DIIKGNKEIT VGAFGVTAVS

GHI
Length:1,253
Mass (Da):139,260
Last modified:July 5, 2004 - v1
Checksum:i4E21F2371612F8E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421447 mRNA. Translation: CAD13342.1.
RefSeqiNP_955435.1. NM_199403.1.
UniGeneiRn.228937.

Genome annotation databases

GeneIDi360863.
KEGGirno:360863.
UCSCiRGD:735185. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421447 mRNA. Translation: CAD13342.1.
RefSeqiNP_955435.1. NM_199403.1.
UniGeneiRn.228937.

3D structure databases

ProteinModelPortaliQ710E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033216.

PTM databases

iPTMnetiQ710E6.
PhosphoSiteiQ710E6.

Proteomic databases

PaxDbiQ710E6.
PRIDEiQ710E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360863.
KEGGirno:360863.
UCSCiRGD:735185. rat.

Organism-specific databases

CTDi51430.
RGDi735185. Suco.

Phylogenomic databases

eggNOGiKOG1396. Eukaryota.
ENOG41116S0. LUCA.
HOVERGENiHBG107549.
InParanoidiQ710E6.
PhylomeDBiQ710E6.

Miscellaneous databases

PROiQ710E6.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR012919. SUN_dom.
[Graphical view]
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of mRNA encoding C1orf9 in brain structures of Rat."
    Verlaet M., Lakaye B., Grisar T.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiSUCO_RAT
AccessioniPrimary (citable) accession number: Q710E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.