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Protein
Submitted name:

Envelope glycoprotein

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
Envelope glycoproteinImported
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation, Viral envelope proteinImported, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ71057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 1 hit.
InterProiIPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q71057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TPLCVSLKCT DLKNDTNTNS SSGRMIMEKG EIKNCSFNIS TSIRGKVQKE
60 70 80 90 100
YAFFYKLDII PIDNDTTSYK LTSCNTSVIT QACPKVSFEP IPIHYCAPAG
110 120 130 140 150
FAILKCNNKT FNGTGPCTNV STVQCTHGIR PVVSTQLLLN GSLAEEEVVI
160 170 180 190 200
RSVNFTDNAK TIIVQLNTSV EINCTRPNNN TRKRIRIQRG PGRAFVTIGK
210 220 230 240 250
IGSMRQAHCN ISRPRWNNTL RQIATRLREQ FGDNKTIIFN QSSGGNPDIV
260 270 280 290 300
THSFNCGGEG FYCNSTHLFN STWHTSTWRA DGSNDTEGSD TITLPCRIKQ
310 320 330 340 350
IINMWQKVGK AMYAPPISGQ IRCSSNITGL LLTRDGGNSN NESEIFRPGG
Length:350
Mass (Da):38,634
Last modified:November 1, 1996 - v1
Checksum:iF7BA4A1C0C3CBBA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei350 – 3501Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16059 mRNA. Translation: AAA86065.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16059 mRNA. Translation: AAA86065.1.

3D structure databases

ProteinModelPortaliQ71057.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.170.40.20. 1 hit.
InterProiIPR000777. HIV1_GP160.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Heteogeneity of V1-V5 regions of the HIV-1 envelope gene from brain, cerebrospinal fluid, and blood from patients with AIDS."
    Xin K.-Q., Shapshak P., Nagano I., Stewart R.V., Srivastava A.K., Wood C., Morikawa S., Ushijima H., Okuda K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "HIV-1 heterogeneity and cytokines. Neuropathogenesis."
    Shapshak P., Nagano I., Xin K., Bradley W., McCoy C.B., Sun N.C.J., Stewart R.V., Yoshioka M., Petito C., Goodkin K., Douyon R., Srivastava A.K., Crandall K.A.
    Adv. Exp. Med. Biol. 373:225-238(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ71057_9HIV1
AccessioniPrimary (citable) accession number: Q71057
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.