Q70Z35 (PREX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Short name=P-Rex2
Short name=PtdIns(3,4,5)-dependent Rac exchanger 2

Alternative name(s):
DEP domain-containing protein 2

Gene names

Name:	PREX2
Synonyms:	DEPDC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1606 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. Ref.1 Ref.5 Ref.6
Subunit structure	Interacts with RAC1.
Tissue specificity	Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. Ref.1
Domain	PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42. DH domain alone was unable to confer substrate specificity and recognition.
Sequence similarities	Contains 2 DEP domains. Contains 1 DH (DBL-homology) domain. Contains 2 PDZ (DHR) domains. Contains 1 PH domain.
Sequence caution	The sequence AK024079 differs from that shown. Reason: Frameshift at position 1134. The sequence BAB14375.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from direct assay Ref.1. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rac GTPase activator activity Inferred from direct assay Ref.1. Source: MGI Rac guanyl-nucleotide exchange factor activity Inferred from direct assay Ref.1. Source: MGI phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q70Z35-1)

Also known as: P-Rex2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q70Z35-2)

Also known as: P-Rexw2A;

The sequence of this isoform differs from the canonical sequence as follows:
     905-905: K → KVLSLQILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKVSVLLQ
     961-978: Missing.
     1016-1060: Missing.
     1108-1108: Y → YF
     1141-1141: G → GG
     1170-1198: DSITNLLKGQAVVRAFDQTKYLTPGRGLQ → QS
     1242-1255: EVKCRLLLALLEYS → T
     1315-1363: GVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVAN → NIILD
     1410-1410: Q → QHVEKLSYKVACKICLLVYT
     1450-1471: AFYLDKSNSPPNSTSKAAYVDK → YVTIQLKNQ
     1535-1535: R → RR
     1570-1577: GARVQNTA → VGLMQTWE
     1578-1606: Missing.

Isoform 3 (identifier: Q70Z35-3)

The sequence of this isoform differs from the canonical sequence as follows:
     906-979: FSRVLKNRAW...HDKENKSSEQ → VQASERFYNF...EMLLAERAPV
     980-1606: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1606	1606	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein		PRO_0000286795
Regions
	Domain	23 – 214	192	DH
	Domain	245 – 361	117	PH
	Domain	390 – 464	75	DEP 1
	Domain	491 – 566	76	DEP 2
	Domain	592 – 671	80	PDZ 1
	Domain	677 – 754	78	PDZ 2
Natural variations
	Alternative sequence	905	1	K → KVLSLQILEALAKSDEHFVQ NCTSLNSLNEVIPTDLQSKF SALCSERIEHLCQRISSYKK VSVLLQ in isoform 2.		VSP_025149
	Alternative sequence	906 – 979	74	FSRVL…KSSEQ → VQASERFYNFTARHAVWEHS FDLHSVSSTFPVPVTMEFLL LPPPLLGISQDGRQHCIPED LPSQEMLLAERAPV in isoform 3.		VSP_025150
	Alternative sequence	961 – 978	18	Missing in isoform 2.		VSP_025151
	Alternative sequence	980 – 1606	627	Missing in isoform 3.		VSP_025152
	Alternative sequence	1016 – 1060	45	Missing in isoform 2.		VSP_025153
	Alternative sequence	1108	1	Y → YF in isoform 2.		VSP_025154
	Alternative sequence	1141	1	G → GG in isoform 2.		VSP_025155
	Alternative sequence	1170 – 1198	29	DSITN…GRGLQ → QS in isoform 2.		VSP_025156
	Alternative sequence	1242 – 1255	14	EVKCR…LLEYS → T in isoform 2.		VSP_025157
	Alternative sequence	1315 – 1363	49	GVLFH…PLVAN → NIILD in isoform 2.		VSP_025158
	Alternative sequence	1410	1	Q → QHVEKLSYKVACKICLLVYT in isoform 2.		VSP_025159
	Alternative sequence	1450 – 1471	22	AFYLD…AYVDK → YVTIQLKNQ in isoform 2.		VSP_025160
	Alternative sequence	1535	1	R → RR in isoform 2.		VSP_025161
	Alternative sequence	1570 – 1577	8	GARVQNTA → VGLMQTWE in isoform 2.		VSP_025162
	Alternative sequence	1578 – 1606	29	Missing in isoform 2.		VSP_025163
	Natural variant	312	1	D → N. Corresponds to variant rs11784582 [ dbSNP | Ensembl ].		VAR_032163
	Natural variant	537	1	V → I in a colorectal cancer sample; somatic mutation. Ref.7		VAR_035973
	Natural variant	1571	1	A → E in a colorectal cancer sample; somatic mutation. Ref.7		VAR_035974
Experimental info
	Sequence conflict	158	1	T → I in AAS82571. Ref.2
	Sequence conflict	158	1	T → I in AAS82572. Ref.2
	Sequence conflict	1076	1	E → V in AAS82571. Ref.2
	Sequence conflict	1076	1	E → V in AK024079. Ref.3
	Sequence conflict	1268	1	C → R in AAS82571. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (P-Rex2) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D9E938D65CE2C7DD	FASTA	1,606	182,622
	10 20 30 40 50 60 MSEDSRGDSR AESAKDLEKQ LRLRVCVLSE LQKTERDYVG TLEFLVSAFL HRMNQCAASK 70 80 90 100 110 120 VDKNVTEETV KMLFSNIEDI LAVHKEFLKV VEECLHPEPN AQQEVGTCFL HFKDKFRIYD 130 140 150 160 170 180 EYCSNHEKAQ KLLLELNKIR TIRTFLLNCM LLGGRKNTDV PLEGYLVTPI QRICKYPLIL 190 200 210 220 230 240 KELLKRTPRK HSDYAAVMEA LQAMKAVCSN INEAKRQMEK LEVLEEWQSH IEGWEGSNIT 250 260 270 280 290 300 DTCTEMLMCG VLLKISSGNI QERVFFLFDN LLVYCKRKHR RLKNSKASTD GHRYLFRGRI 310 320 330 340 350 360 NTEVMEVENV DDGTADFHSS GHIVVNGWKI HNTAKNKWFV CMAKTPEEKH EWFEAILKER 370 380 390 400 410 420 ERRKGLKLGM EQDTWVMISE QGEKLYKMMC RQGNLIKDRK RKLTTFPKCF LGSEFVSWLL 430 440 450 460 470 480 EIGEIHRPEE GVHLGQALLE NGIIHHVTDK HQFKPEQMLY RFRYDDGTFY PRNEMQDVIS 490 500 510 520 530 540 KGVRLYCRLH SLFTPVIRDK DYHLRTYKSV VMANKLIDWL IAQGDCRTRE EAMIFGVGLC 550 560 570 580 590 600 DNGFMHHVLE KSEFKDEPLL FRFFSDEEME GSNMKHRLMK HDLKVVENVI AKSLLIKSNE 610 620 630 640 650 660 GSYGFGLEDK NKVPIIKLVE KGSNAEMAGM EVGKKIFAIN GDLVFMRPFN EVDCFLKSCL 670 680 690 700 710 720 NSRKPLRVLV STKPRETVKI PDSADGLGFQ IRGFGPSVVH AVGRGTVAAA AGLHPGQCII 730 740 750 760 770 780 KVNGINVSKE THASVIAHVT ACRKYRRPTK QDSIQWVYNS IESAQEDLQK SHSKPPGDEA 790 800 810 820 830 840 GDAFDCKVEE VIDKFNTMAI IDGKKEHVSL TVDNVHLEYG VVYEYDSTAG IKCNVVEKMI 850 860 870 880 890 900 EPKGFFSLTA KILEALAKSD EHFVQNCTSL NSLNEVIPTD LQSKFSALCS ERIEHLCQRI 910 920 930 940 950 960 SSYKKFSRVL KNRAWPTFKQ AKSKISPLHS SDFCPTNCHV NVMEVSYPKT STSLGSAFGV 970 980 990 1000 1010 1020 QLDSRKHNSH DKENKSSEQG KLSPMVYIQH TITTMAAPSG LSLGQQDGHG LRYLLKEEDL 1030 1040 1050 1060 1070 1080 ETQDIYQKLL GKLQTALKEV EMCVCQIDDL LSSITYSPKL ERKTSEGIIP TDSDNEKGER 1090 1100 1110 1120 1130 1140 NSKRVCFNVA GDEQEDSGHD TISNRDSYSD CNSNRNSIAS FTSICSSQCS SYFHSDEMDS 1150 1160 1170 1180 1190 1200 GDELPLSVRI SHDKQDKIHS CLEHLFSQVD SITNLLKGQA VVRAFDQTKY LTPGRGLQEF 1210 1220 1230 1240 1250 1260 QQEMEPKLSC PKRLRLHIKQ DPWNLPSSVR TLAQNIRKFV EEVKCRLLLA LLEYSDSETQ 1270 1280 1290 1300 1310 1320 LRRDMVFCQT LVATVCAFSE QLMAALNQMF DNSKENEMET WEASRRWLDQ IANAGVLFHF 1330 1340 1350 1360 1370 1380 QSLLSPNLTD EQAMLEDTLV ALFDLEKVSF YFKPSEEEPL VANVPLTYQA EGSRQALKVY 1390 1400 1410 1420 1430 1440 FYIDSYHFEQ LPQRLKNGGG FKIHPVLFAQ ALESMEGYYY RDNVSVEEFQ AQINAASLEK 1450 1460 1470 1480 1490 1500 VKQYNQKLRA FYLDKSNSPP NSTSKAAYVD KLMRPLNALD ELYRLVASFI RSKRTAACAN 1510 1520 1530 1540 1550 1560 TACSASGVGL LSVSSELCNR LGACHIIMCS SGVHRCTLSV TLEQAIILAR SHGLPPRYIM 1570 1580 1590 1600 QATDVMRKQG ARVQNTAKNL GVRDRTPQSA PRLYKLCEPP PPAGEE
	Isoform 2 (P-Rexw2A) [UniParc]. Checksum: 7395DCD2CED55256	FASTA	1,504	171,373
	10 20 30 40 50 60 MSEDSRGDSR AESAKDLEKQ LRLRVCVLSE LQKTERDYVG TLEFLVSAFL HRMNQCAASK 70 80 90 100 110 120 VDKNVTEETV KMLFSNIEDI LAVHKEFLKV VEECLHPEPN AQQEVGTCFL HFKDKFRIYD 130 140 150 160 170 180 EYCSNHEKAQ KLLLELNKIR TIRTFLLNCM LLGGRKNTDV PLEGYLVTPI QRICKYPLIL 190 200 210 220 230 240 KELLKRTPRK HSDYAAVMEA LQAMKAVCSN INEAKRQMEK LEVLEEWQSH IEGWEGSNIT 250 260 270 280 290 300 DTCTEMLMCG VLLKISSGNI QERVFFLFDN LLVYCKRKHR RLKNSKASTD GHRYLFRGRI 310 320 330 340 350 360 NTEVMEVENV DDGTADFHSS GHIVVNGWKI HNTAKNKWFV CMAKTPEEKH EWFEAILKER 370 380 390 400 410 420 ERRKGLKLGM EQDTWVMISE QGEKLYKMMC RQGNLIKDRK RKLTTFPKCF LGSEFVSWLL 430 440 450 460 470 480 EIGEIHRPEE GVHLGQALLE NGIIHHVTDK HQFKPEQMLY RFRYDDGTFY PRNEMQDVIS 490 500 510 520 530 540 KGVRLYCRLH SLFTPVIRDK DYHLRTYKSV VMANKLIDWL IAQGDCRTRE EAMIFGVGLC 550 560 570 580 590 600 DNGFMHHVLE KSEFKDEPLL FRFFSDEEME GSNMKHRLMK HDLKVVENVI AKSLLIKSNE 610 620 630 640 650 660 GSYGFGLEDK NKVPIIKLVE KGSNAEMAGM EVGKKIFAIN GDLVFMRPFN EVDCFLKSCL 670 680 690 700 710 720 NSRKPLRVLV STKPRETVKI PDSADGLGFQ IRGFGPSVVH AVGRGTVAAA AGLHPGQCII 730 740 750 760 770 780 KVNGINVSKE THASVIAHVT ACRKYRRPTK QDSIQWVYNS IESAQEDLQK SHSKPPGDEA 790 800 810 820 830 840 GDAFDCKVEE VIDKFNTMAI IDGKKEHVSL TVDNVHLEYG VVYEYDSTAG IKCNVVEKMI 850 860 870 880 890 900 EPKGFFSLTA KILEALAKSD EHFVQNCTSL NSLNEVIPTD LQSKFSALCS ERIEHLCQRI 910 920 930 940 950 960 SSYKKVLSLQ ILEALAKSDE HFVQNCTSLN SLNEVIPTDL QSKFSALCSE RIEHLCQRIS 970 980 990 1000 1010 1020 SYKKVSVLLQ FSRVLKNRAW PTFKQAKSKI SPLHSSDFCP TNCHVNVMEV SYPKTSTSLG 1030 1040 1050 1060 1070 1080 SAFGVQGKLS PMVYIQHTIT TMAAPSGLSL GQQDGHGLRY LLERKTSEGI IPTDSDNEKG 1090 1100 1110 1120 1130 1140 ERNSKRVCFN VAGDEQEDSG HDTISNRDSY FSDCNSNRNS IASFTSICSS QCSSYFHSDE 1150 1160 1170 1180 1190 1200 MDSGGDELPL SVRISHDKQD KIHSCLEHLF SQVQSEFQQE MEPKLSCPKR LRLHIKQDPW 1210 1220 1230 1240 1250 1260 NLPSSVRTLA QNIRKFVETD SETQLRRDMV FCQTLVATVC AFSEQLMAAL NQMFDNSKEN 1270 1280 1290 1300 1310 1320 EMETWEASRR WLDQIANANI ILDVPLTYQA EGSRQALKVY FYIDSYHFEQ LPQRLKNGGG 1330 1340 1350 1360 1370 1380 FKIHPVLFAQ HVEKLSYKVA CKICLLVYTA LESMEGYYYR DNVSVEEFQA QINAASLEKV 1390 1400 1410 1420 1430 1440 KQYNQKLRYV TIQLKNQLMR PLNALDELYR LVASFIRSKR TAACANTACS ASGVGLLSVS 1450 1460 1470 1480 1490 1500 SELCNRLGAC HIIMCSSGVH RRCTLSVTLE QAIILARSHG LPPRYIMQAT DVMRKQVGLM QTWE
	Isoform 3 [UniParc]. Checksum: 98B38EB98ED26657	FASTA	979	112,091
	10 20 30 40 50 60 MSEDSRGDSR AESAKDLEKQ LRLRVCVLSE LQKTERDYVG TLEFLVSAFL HRMNQCAASK 70 80 90 100 110 120 VDKNVTEETV KMLFSNIEDI LAVHKEFLKV VEECLHPEPN AQQEVGTCFL HFKDKFRIYD 130 140 150 160 170 180 EYCSNHEKAQ KLLLELNKIR TIRTFLLNCM LLGGRKNTDV PLEGYLVTPI QRICKYPLIL 190 200 210 220 230 240 KELLKRTPRK HSDYAAVMEA LQAMKAVCSN INEAKRQMEK LEVLEEWQSH IEGWEGSNIT 250 260 270 280 290 300 DTCTEMLMCG VLLKISSGNI QERVFFLFDN LLVYCKRKHR RLKNSKASTD GHRYLFRGRI 310 320 330 340 350 360 NTEVMEVENV DDGTADFHSS GHIVVNGWKI HNTAKNKWFV CMAKTPEEKH EWFEAILKER 370 380 390 400 410 420 ERRKGLKLGM EQDTWVMISE QGEKLYKMMC RQGNLIKDRK RKLTTFPKCF LGSEFVSWLL 430 440 450 460 470 480 EIGEIHRPEE GVHLGQALLE NGIIHHVTDK HQFKPEQMLY RFRYDDGTFY PRNEMQDVIS 490 500 510 520 530 540 KGVRLYCRLH SLFTPVIRDK DYHLRTYKSV VMANKLIDWL IAQGDCRTRE EAMIFGVGLC 550 560 570 580 590 600 DNGFMHHVLE KSEFKDEPLL FRFFSDEEME GSNMKHRLMK HDLKVVENVI AKSLLIKSNE 610 620 630 640 650 660 GSYGFGLEDK NKVPIIKLVE KGSNAEMAGM EVGKKIFAIN GDLVFMRPFN EVDCFLKSCL 670 680 690 700 710 720 NSRKPLRVLV STKPRETVKI PDSADGLGFQ IRGFGPSVVH AVGRGTVAAA AGLHPGQCII 730 740 750 760 770 780 KVNGINVSKE THASVIAHVT ACRKYRRPTK QDSIQWVYNS IESAQEDLQK SHSKPPGDEA 790 800 810 820 830 840 GDAFDCKVEE VIDKFNTMAI IDGKKEHVSL TVDNVHLEYG VVYEYDSTAG IKCNVVEKMI 850 860 870 880 890 900 EPKGFFSLTA KILEALAKSD EHFVQNCTSL NSLNEVIPTD LQSKFSALCS ERIEHLCQRI 910 920 930 940 950 960 SSYKKVQASE RFYNFTARHA VWEHSFDLHS VSSTFPVPVT MEFLLLPPPL LGISQDGRQH 970 CIPEDLPSQE MLLAERAPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"P-Rex2, a new guanine-nucleotide exchange factor for Rac." Donald S., Hill K., Lecureuil C., Barnouin R., Krugmann S., John Coadwell W., Andrews S.R., Walker S.A., Hawkins P.T., Stephens L.R., Welch H.C.E. FEBS Lett. 572:172-176(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Brain and Skeletal muscle.
[2]	"Cloning and characterization of P-Rex2: an inositol polyphosphate 4-phosphatase domain containing guanine nucleotide exchange factor." Joseph R.E., Norris F.A. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Tissue: Mammary gland.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1588 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1588 (ISOFORM 1). Tissue: Embryo and Teratocarcinoma.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"P-REX2, a novel PI-3-kinase sensitive Rac exchange factor." Rosenfeldt H., Vazquez-Prado J., Gutkind J.S. FEBS Lett. 572:167-171(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORMS 2 AND 3), FUNCTION, ALTERNATIVE SPLICING.
[6]	"Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2." Joseph R.E., Norris F.A. J. Biol. Chem. 280:27508-27512(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-537 AND GLU-1571.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ437636 mRNA. Translation: CAD26885.2. AY508996 mRNA. Translation: AAS82571.1. AY508997 mRNA. Translation: AAS82572.1. AK023049 mRNA. Translation: BAB14375.1. Different initiation. AK024079 mRNA. No translation available. AC011853 Genomic DNA. No translation available. AC103783 Genomic DNA. No translation available. AC104416 Genomic DNA. No translation available. BK005160 mRNA. Translation: DAA05333.1. BK005161 mRNA. Translation: DAA05334.1.
IPI	IPI00418875. IPI00418876. IPI00845229.
RefSeq	NP_079146.2. NM_024870.2. NP_079446.3. NM_025170.4.
UniGene	Hs.591867.
3D structure databases
HSSP	HSSP built from PDB template 1XDV based on UniProtKB Q07889.
ProteinModelPortal	Q70Z35.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q70Z35. 4 interactions.
STRING	9606.ENSP00000288368.
PTM databases
PhosphoSite	Q70Z35.
Polymorphism databases
DMDM	74758897.
Proteomic databases
PaxDb	Q70Z35.
PRIDE	Q70Z35.
Protocols and materials databases
DNASU	80243.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288368; ENSP00000288368; ENSG00000046889.
GeneID	80243.
KEGG	hsa:80243.
UCSC	uc003xxu.1. human. uc003xxv.1. human.
Organism-specific databases
CTD	80243.
GeneCards	GC08P068864.
HGNC	HGNC:22950. PREX2.
HPA	HPA015234.
MIM	612139. gene.
neXtProt	NX_Q70Z35.
PharmGKB	PA164725103.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5422.
HOVERGEN	HBG053677.
OMA	ITDTCTE.
OrthoDB	EOG42820Q.
PhylomeDB	Q70Z35.
Gene expression databases
ArrayExpress	Q70Z35.
Bgee	Q70Z35.
CleanEx	HS_PREX2.
Genevestigator	Q70Z35.
Family and domain databases
Gene3D	1.10.10.10. 2 hits. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000591. DEP_dom. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 2 hits. PF00595. PDZ. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00049. DEP. 2 hits. SM00228. PDZ. 2 hits. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50156. PDZ. 2 hits.
PROSITE	PS50186. DEP. 2 hits. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 2 hits. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80243.
NextBio	70689.
SOURCE	Search...

Entry information

Entry name

PREX2_HUMAN

Accession

Primary (citable) accession number: Q70Z35
Secondary accession number(s): Q32KL0 , Q32KL1, Q6R7Q3, Q6R7Q4, Q9H805, Q9H961

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.