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Q70YC5

- ZN365_HUMAN

UniProt

Q70YC5 - ZN365_HUMAN

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Protein

Protein ZNF365

Gene

ZNF365

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
Protein su48
Gene namesi
Name:ZNF365
Synonyms:KIAA0844
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:18194. ZNF365.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
Note: localizes to the centrosome at all stages of the cell cycle.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Protein ZNF365PRO_0000076374Add
BLAST

Proteomic databases

PRIDEiQ70YC5.

PTM databases

PhosphoSiteiQ70YC5.

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ70YC5.
CleanExiHS_ZNF365.
ExpressionAtlasiQ70YC5. baseline and differential.
GenevestigatoriQ70YC5.

Organism-specific databases

HPAiHPA052446.

Interactioni

Subunit structurei

Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NDE1Q9NXR14EBI-941182,EBI-941227

Protein-protein interaction databases

BioGridi116557. 2 interactions.
IntActiQ70YC5. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70YC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili169 – 297129Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00530000063713.
HOVERGENiHBG094181.
InParanoidiQ70YC5.
KOiK16737.
OMAiKSIHEQA.
PhylomeDBiQ70YC5.
TreeFamiTF329439.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q70YC5-1) [UniParc]FASTAAdd to Basket

Also known as: ZNF365A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN
110 120 130 140 150
LYSISHEHSK DRKPFEVVAE RPVSYVQTYT AMDLHADSLD GTRSGPGLPT
160 170 180 190 200
SDTKASFEAH VREKFNRMVE AVDRTIEKRI DKLTKELAQK TAELLEVRAA
210 220 230 240 250
FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE EELLRKEEEV
260 270 280 290 300
VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF
310 320 330 340 350
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA
360 370 380 390 400
KDDRASMQPA KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP

TAIVNII
Length:407
Mass (Da):46,542
Last modified:January 11, 2011 - v3
Checksum:iCC3C25AF6A753E64
GO
Isoform 2 (identifier: Q70YC5-2) [UniParc]FASTAAdd to Basket

Also known as: ZNF365B

The sequence of this isoform differs from the canonical sequence as follows:
     309-333: LTDISSNRKPKCLSRGHPHSVCNHP → SWKGAGEARLVCQNDLELEESAIVE
     334-407: Missing.

Show »
Length:333
Mass (Da):38,217
Checksum:i6C143290C74C9BA2
GO
Isoform 3 (identifier: Q70YC5-3) [UniParc]FASTAAdd to Basket

Also known as: ZNF365C

The sequence of this isoform differs from the canonical sequence as follows:
     309-407: LTDISSNRKP...KKPTAIVNII → SWKGAGEARL...CFPWGLPSSS

Show »
Length:462
Mass (Da):52,501
Checksum:i52B5B9170F4C1EC5
GO
Isoform 5 (identifier: Q70YC5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTMRPPQSCEPTFRVM

Note: No experimental confirmation available.

Show »
Length:422
Mass (Da):48,304
Checksum:iD9ACEBDD206A5889
GO
Isoform 6 (identifier: Q70YC5-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Note: No experimental confirmation available.

Show »
Length:51
Mass (Da):5,654
Checksum:iD16DB9DAA8FAD040
GO
Isoform 4 (identifier: Q70YC4-1) [UniParc]FASTAAdd to Basket

Also known as: Talanin, ZNF365D

The sequence of this isoform can be found in the external entry Q70YC4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:216
Mass (Da):24,036
GO

Sequence cautioni

The sequence AAH17841.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA74867.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551E → Q in AAT27443. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti337 – 3371A → S.4 Publications
Corresponds to variant rs3758490 [ dbSNP | Ensembl ].
VAR_024325

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 356356Missing in isoform 6. 1 PublicationVSP_016596Add
BLAST
Alternative sequencei1 – 11M → MTMRPPQSCEPTFRVM in isoform 5. 1 PublicationVSP_016597
Alternative sequencei309 – 40799LTDIS…IVNII → SWKGAGEARLVCQNDLELEI FGHINHHLSGLKDSHCLVFL QAPPVPWIILASFLWILGNP WTSSTATAGFSQIWVLFPFC GGTFHHNEKDVLGLQDFERE SVSTSQSRNISLLTLGQLQN CVIGKLTIIDLLTEHLLGVR HGVICFPWGLPSSS in isoform 3. 1 PublicationVSP_016598Add
BLAST
Alternative sequencei309 – 33325LTDIS…VCNHP → SWKGAGEARLVCQNDLELEE SAIVE in isoform 2. 1 PublicationVSP_016599Add
BLAST
Alternative sequencei334 – 40774Missing in isoform 2. 1 PublicationVSP_016600Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505147 mRNA. Translation: CAD43726.1.
AJ505148 mRNA. Translation: CAD43727.1.
AJ505149 mRNA. Translation: CAD43728.1.
AB020651 mRNA. Translation: BAA74867.2. Different initiation.
AK289515 mRNA. Translation: BAF82204.1.
AK289808 mRNA. Translation: BAF82497.1.
BX647904 mRNA. Translation: CAI46100.1.
AC024597 Genomic DNA. No translation available.
AC024598 Genomic DNA. No translation available.
BC017841 mRNA. Translation: AAH17841.1. Sequence problems.
BC035049 mRNA. Translation: AAH35049.1.
BC060817 mRNA. Translation: AAH60817.1.
AY547355 Genomic DNA. Translation: AAT27443.1.
CCDSiCCDS31209.1. [Q70YC5-1]
CCDS41531.1. [Q70YC5-2]
CCDS7264.1. [Q70YC5-3]
RefSeqiNP_055766.2. NM_014951.2. [Q70YC5-1]
NP_955522.1. NM_199450.2. [Q70YC5-2]
NP_955523.1. NM_199451.2. [Q70YC5-3]
UniGeneiHs.22653.

Genome annotation databases

EnsembliENST00000395254; ENSP00000378674; ENSG00000138311. [Q70YC5-1]
ENST00000395255; ENSP00000378675; ENSG00000138311. [Q70YC5-2]
ENST00000410046; ENSP00000387091; ENSG00000138311. [Q70YC5-3]
GeneIDi22891.
KEGGihsa:22891.
UCSCiuc001jly.4. human. [Q70YC5-4]
uc001jlz.4. human. [Q70YC5-1]
uc001jmb.4. human. [Q70YC5-2]
uc001jmc.2. human. [Q70YC5-3]

Polymorphism databases

DMDMi317373495.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ505147 mRNA. Translation: CAD43726.1 .
AJ505148 mRNA. Translation: CAD43727.1 .
AJ505149 mRNA. Translation: CAD43728.1 .
AB020651 mRNA. Translation: BAA74867.2 . Different initiation.
AK289515 mRNA. Translation: BAF82204.1 .
AK289808 mRNA. Translation: BAF82497.1 .
BX647904 mRNA. Translation: CAI46100.1 .
AC024597 Genomic DNA. No translation available.
AC024598 Genomic DNA. No translation available.
BC017841 mRNA. Translation: AAH17841.1 . Sequence problems.
BC035049 mRNA. Translation: AAH35049.1 .
BC060817 mRNA. Translation: AAH60817.1 .
AY547355 Genomic DNA. Translation: AAT27443.1 .
CCDSi CCDS31209.1. [Q70YC5-1 ]
CCDS41531.1. [Q70YC5-2 ]
CCDS7264.1. [Q70YC5-3 ]
RefSeqi NP_055766.2. NM_014951.2. [Q70YC5-1 ]
NP_955522.1. NM_199450.2. [Q70YC5-2 ]
NP_955523.1. NM_199451.2. [Q70YC5-3 ]
UniGenei Hs.22653.

3D structure databases

ProteinModelPortali Q70YC5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116557. 2 interactions.
IntActi Q70YC5. 3 interactions.

PTM databases

PhosphoSitei Q70YC5.

Polymorphism databases

DMDMi 317373495.

Proteomic databases

PRIDEi Q70YC5.

Protocols and materials databases

DNASUi 22891.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395254 ; ENSP00000378674 ; ENSG00000138311 . [Q70YC5-1 ]
ENST00000395255 ; ENSP00000378675 ; ENSG00000138311 . [Q70YC5-2 ]
ENST00000410046 ; ENSP00000387091 ; ENSG00000138311 . [Q70YC5-3 ]
GeneIDi 22891.
KEGGi hsa:22891.
UCSCi uc001jly.4. human. [Q70YC5-4 ]
uc001jlz.4. human. [Q70YC5-1 ]
uc001jmb.4. human. [Q70YC5-2 ]
uc001jmc.2. human. [Q70YC5-3 ]

Organism-specific databases

CTDi 22891.
GeneCardsi GC10P064133.
HGNCi HGNC:18194. ZNF365.
HPAi HPA052446.
MIMi 607818. gene.
neXtProti NX_Q70YC5.
PharmGKBi PA134873576.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063713.
HOVERGENi HBG094181.
InParanoidi Q70YC5.
KOi K16737.
OMAi KSIHEQA.
PhylomeDBi Q70YC5.
TreeFami TF329439.

Miscellaneous databases

GenomeRNAii 22891.
NextBioi 43497.
SOURCEi Search...

Gene expression databases

Bgeei Q70YC5.
CleanExi HS_ZNF365.
ExpressionAtlasi Q70YC5. baseline and differential.
Genevestigatori Q70YC5.

Family and domain databases

InterProi IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate."
    Gianfrancesco F., Esposito T., Ombra M.N., Forabosco P., Maninchedda G., Fattorini M., Casula S., Vaccargiu S., Casu G., Cardia F., Deiana I., Melis P., Falchi M., Pirastu M.
    Am. J. Hum. Genet. 72:1479-1491(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT SER-337, TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-337.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-337.
    Tissue: Brain and Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT SER-337.
    Tissue: Cervix.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-394 (ISOFORM 1).
    Tissue: Brain and Lung.
  7. Anitha A., Nakamura K., Mori N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
  8. "Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage."
    Gianfrancesco F., Esposito T., Casu G., Maninchedda G., Roberto R., Parastu M.
    Gene 339:131-138(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  9. "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation."
    Hirohashi Y., Wang Q., Liu Q., Li B., Du X., Zhang H., Furuuchi K., Masuda K., Sato N., Greene M.I.
    Oncogene 25:6048-6055(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NDE1 AND NDEL1.
  10. "Characterization of Su48, a centrosome protein essential for cell division."
    Wang Q., Du X., Meinkoth J., Hirohashi Y., Zhang H., Liu Q., Richter M., Greene M.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:6512-6517(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZN365_HUMAN
AccessioniPrimary (citable) accession number: Q70YC5
Secondary accession number(s): A8K0F0
, O94930, Q05D75, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3