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Q70YC5 (ZN365_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ZNF365
Alternative name(s):
Protein su48
Gene names
Name:ZNF365
Synonyms:KIAA0844
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1. Ref.9 Ref.10

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Note: localizes to the centrosome at all stages of the cell cycle. Ref.10

Tissue specificity

Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas. Ref.1

Sequence caution

The sequence AAH17841.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence BAA74867.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction Ref.9. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NDE1Q9NXR14EBI-941182,EBI-941227

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q70YC5-1)

Also known as: ZNF365A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q70YC5-2)

Also known as: ZNF365B;

The sequence of this isoform differs from the canonical sequence as follows:
     309-333: LTDISSNRKPKCLSRGHPHSVCNHP → SWKGAGEARLVCQNDLELEESAIVE
     334-407: Missing.
Isoform 3 (identifier: Q70YC5-3)

Also known as: ZNF365C;

The sequence of this isoform differs from the canonical sequence as follows:
     309-407: LTDISSNRKP...KKPTAIVNII → SWKGAGEARL...CFPWGLPSSS
Isoform 5 (identifier: Q70YC5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTMRPPQSCEPTFRVM
Note: No experimental confirmation available.
Isoform 6 (identifier: Q70YC5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q70YC4-1)

Also known as: Talanin; ZNF365D;

The sequence of this isoform can be found in the external entry Q70YC4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Protein ZNF365
PRO_0000076374

Regions

Coiled coil169 – 297129 Potential

Natural variations

Alternative sequence1 – 356356Missing in isoform 6.
VSP_016596
Alternative sequence11M → MTMRPPQSCEPTFRVM in isoform 5.
VSP_016597
Alternative sequence309 – 40799LTDIS…IVNII → SWKGAGEARLVCQNDLELEI FGHINHHLSGLKDSHCLVFL QAPPVPWIILASFLWILGNP WTSSTATAGFSQIWVLFPFC GGTFHHNEKDVLGLQDFERE SVSTSQSRNISLLTLGQLQN CVIGKLTIIDLLTEHLLGVR HGVICFPWGLPSSS in isoform 3.
VSP_016598
Alternative sequence309 – 33325LTDIS…VCNHP → SWKGAGEARLVCQNDLELEE SAIVE in isoform 2.
VSP_016599
Alternative sequence334 – 40774Missing in isoform 2.
VSP_016600
Natural variant3371A → S. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs3758490 [ dbSNP | Ensembl ].
VAR_024325

Experimental info

Sequence conflict551E → Q in AAT27443. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ZNF365A) [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: CC3C25AF6A753E64

FASTA40746,542
        10         20         30         40         50         60 
MQQKAFEESR YPWQESFENV AVCLPLRCPR CGDHTRFRSL SSLRAHLEFS HSYEERTLLT 

        70         80         90        100        110        120 
KCSLFPSLKD TDLVTSSELL KPGKLQSSGN VVKQKPSYVN LYSISHEHSK DRKPFEVVAE 

       130        140        150        160        170        180 
RPVSYVQTYT AMDLHADSLD GTRSGPGLPT SDTKASFEAH VREKFNRMVE AVDRTIEKRI 

       190        200        210        220        230        240 
DKLTKELAQK TAELLEVRAA FVQLTQKKQE VQRRERALNR QVDVAVEMIA VLRQRLTESE 

       250        260        270        280        290        300 
EELLRKEEEV VTFNHFLEAA AEKEVQGKAR LQDFIENLLQ RVELAEKQLE YYQSQQASGF 

       310        320        330        340        350        360 
VRDLSGHVLT DISSNRKPKC LSRGHPHSVC NHPDLKAHFH PKGRNHLKKA KDDRASMQPA 

       370        380        390        400 
KAIHEQAESS RDLCRPPKKG ELLGFGRKGN IRPKMAKKKP TAIVNII 

« Hide

Isoform 2 (ZNF365B) [UniParc].

Checksum: 6C143290C74C9BA2
Show »

FASTA33338,217
Isoform 3 (ZNF365C) [UniParc].

Checksum: 52B5B9170F4C1EC5
Show »

FASTA46252,501
Isoform 5 [UniParc].

Checksum: D9ACEBDD206A5889
Show »

FASTA42248,304
Isoform 6 [UniParc].

Checksum: D16DB9DAA8FAD040
Show »

FASTA515,654
Isoform 4 (Talanin) (ZNF365D) [UniParc].

See Q70YC4.

References

« Hide 'large scale' references
[1]"Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate."
Gianfrancesco F., Esposito T., Ombra M.N., Forabosco P., Maninchedda G., Fattorini M., Casula S., Vaccargiu S., Casu G., Cardia F., Deiana I., Melis P., Falchi M., Pirastu M.
Am. J. Hum. Genet. 72:1479-1491(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT SER-337, TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-337.
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-337.
Tissue: Brain and Cerebellum.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT SER-337.
Tissue: Cervix.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-394 (ISOFORM 1).
Tissue: Brain and Lung.
[7]Anitha A., Nakamura K., Mori N.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-247.
[8]"Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage."
Gianfrancesco F., Esposito T., Casu G., Maninchedda G., Roberto R., Parastu M.
Gene 339:131-138(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.
[9]"Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation."
Hirohashi Y., Wang Q., Liu Q., Li B., Du X., Zhang H., Furuuchi K., Masuda K., Sato N., Greene M.I.
Oncogene 25:6048-6055(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NDE1 AND NDEL1.
[10]"Characterization of Su48, a centrosome protein essential for cell division."
Wang Q., Du X., Meinkoth J., Hirohashi Y., Zhang H., Liu Q., Richter M., Greene M.I.
Proc. Natl. Acad. Sci. U.S.A. 103:6512-6517(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: HOMODIMERIZATION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ505147 mRNA. Translation: CAD43726.1.
AJ505148 mRNA. Translation: CAD43727.1.
AJ505149 mRNA. Translation: CAD43728.1.
AB020651 mRNA. Translation: BAA74867.2. Different initiation.
AK289515 mRNA. Translation: BAF82204.1.
AK289808 mRNA. Translation: BAF82497.1.
BX647904 mRNA. Translation: CAI46100.1.
AC024597 Genomic DNA. No translation available.
AC024598 Genomic DNA. No translation available.
BC017841 mRNA. Translation: AAH17841.1. Sequence problems.
BC035049 mRNA. Translation: AAH35049.1.
BC060817 mRNA. Translation: AAH60817.1.
AY547355 Genomic DNA. Translation: AAT27443.1.
CCDSCCDS31209.1. [Q70YC5-1]
CCDS41531.1. [Q70YC5-2]
CCDS7264.1. [Q70YC5-3]
RefSeqNP_055766.2. NM_014951.2. [Q70YC5-1]
NP_955522.1. NM_199450.2. [Q70YC5-2]
NP_955523.1. NM_199451.2. [Q70YC5-3]
UniGeneHs.22653.

3D structure databases

ProteinModelPortalQ70YC5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116557. 2 interactions.
IntActQ70YC5. 3 interactions.

PTM databases

PhosphoSiteQ70YC5.

Polymorphism databases

DMDM317373495.

Proteomic databases

PRIDEQ70YC5.

Protocols and materials databases

DNASU22891.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395254; ENSP00000378674; ENSG00000138311. [Q70YC5-1]
ENST00000395255; ENSP00000378675; ENSG00000138311. [Q70YC5-2]
ENST00000410046; ENSP00000387091; ENSG00000138311. [Q70YC5-3]
GeneID22891.
KEGGhsa:22891.
UCSCuc001jly.4. human. [Q70YC5-4]
uc001jlz.4. human. [Q70YC5-1]
uc001jmb.4. human. [Q70YC5-2]
uc001jmc.2. human. [Q70YC5-3]

Organism-specific databases

CTD22891.
GeneCardsGC10P064133.
HGNCHGNC:18194. ZNF365.
HPAHPA052446.
MIM607818. gene.
neXtProtNX_Q70YC5.
PharmGKBPA134873576.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG094181.
KOK16737.
OMAKSIHEQA.
PhylomeDBQ70YC5.
TreeFamTF329439.

Gene expression databases

ArrayExpressQ70YC5.
BgeeQ70YC5.
CleanExHS_ZNF365.
GenevestigatorQ70YC5.

Family and domain databases

InterProIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi22891.
NextBio43497.
SOURCESearch...

Entry information

Entry nameZN365_HUMAN
AccessionPrimary (citable) accession number: Q70YC5
Secondary accession number(s): A8K0F0 expand/collapse secondary AC list , O94930, Q05D75, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM