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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic

Gene

accD

Organism
Amborella trichopoda
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi271Zinc1
Metal bindingi274Zinc1
Metal bindingi290Zinc1
Metal bindingi293Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C4-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Encoded oniPlastid; Chloroplast
OrganismiAmborella trichopoda
Taxonomic identifieri13333 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytabasal MagnoliophytaAmborellalesAmborellaceaeAmborella
Proteomesi
  • UP000017836 Componenti: Chloroplast

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003591201 – 540Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplasticAdd BLAST540

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ70XZ4.
SMRiQ70XZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini267 – 538CoA carboxyltransferase N-terminalAdd BLAST272

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C4-typeAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

KOiK01963.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70XZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKCGFNSML SNEELEHKCE LSKSMDSLGL IGNTGAGGGP TLIFDVRDIL
60 70 80 90 100
SLIYDDTFKL KDRNGDSYSV YFDIDNKIFE IDDDSDSLSG LDIENQNQIF
110 120 130 140 150
FDIYNDSDSL SELDSENKNF EIHNESDFMS KLESSFFSYL TYSCLKRRSS
160 170 180 190 200
FSSYPTSLTS SNLNSGSKSY NPYYDPYMHD TRYSWNNDIN INSCIDSYIR
210 220 230 240 250
CEIDSISSGS DNCSDSYIYS YICSEGVSYS DNGSSSIRTR TSTSSGSSYH
260 270 280 290 300
IRGRSNNFEK NKKLKKLWVQ CENCYALNYN KLFRSKMNVC EQCGYHLKMS
310 320 330 340 350
SSDRIELSID PGTWHPMDED MVSTDPIEFH SEEEPYRDRI DSYQRQAGLT
360 370 380 390 400
DAVQTGIGQL EGIPIAIGVM DFQFMGGSMG SVVGEKITRL IEYAIDRSLP
410 420 430 440 450
VVIVCASGGA RMQEGGLSLM QMAKISSASY NYQSNKKLFY VSILTSPTTG
460 470 480 490 500
GVTASFGMLG DIIIAEPNAY VAFAGKRVIE ETLNKKIPDG LQVAEYSFHK
510 520 530 540
GLFDSIVPRN PLKGVPSELF QLHGFFSSTF HPLKSNKVKR
Length:540
Mass (Da):60,527
Last modified:July 5, 2004 - v1
Checksum:i417396E600A9CDF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ506156 Genomic DNA. Translation: CAD45116.1.
RefSeqiNP_904108.1. NC_005086.1.

Genome annotation databases

GeneIDi2546605.
KEGGiatr:2546605.

Similar proteinsi

Entry informationi

Entry nameiACCD_AMBTC
AccessioniPrimary (citable) accession number: Q70XZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families