Unreviewed, UniProtKB/TrEMBL Q70X90 (Q70X90_RAT)

Names and origin

Protein names

Submitted name:
    Sulphonylurea receptor 1 EMBL CAD54072.1

Gene names

Name:	Abcc8 RGD 3786
Synonyms:	sur1 EMBL CAD54072.1

Organism

Rattus norvegicus (Rat) EMBL CAD54072.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter family. RuleBase RU000684V4

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000684V4 Nucleotide-binding
Molecular function	Receptor EMBL CAD54072.1
Gene Ontology (GO)
Biological process	negative regulation of insulin secretion Inferred from direct assay. Source: RGD positive regulation of potassium ion transport Inferred from direct assay. Source: RGD potassium ion transport Inferred from electronic annotation. Source: InterPro response to drug Inferred from expression pattern. Source: RGD response to insulin stimulus Inferred from expression pattern. Source: RGD response to lipopolysaccharide Inferred from expression pattern. Source: RGD response to pH Inferred from direct assay. Source: RGD response to zinc ion Inferred from direct assay. Source: RGD
Cellular component	ATP-sensitive potassium channel complex Inferred from mutant phenotype. Source: RGD sarcolemma Inferred from direct assay. Source: RGD synaptic vesicle membrane Inferred from mutant phenotype. Source: RGD
Molecular function	ATP binding Inferred from mutant phenotype. Source: RGD ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro potassium channel activity Inferred from mutant phenotype. Source: RGD sulfonylurea receptor activity Traceable author statement. Source: RGD syntaxin binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q70X90-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E50FCCD3662EDBD4	FASTA	1,556	174,024
	10 20 30 40 50 60 MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG WGSQSSKVHI 70 80 90 100 110 120 HHSTWLHFPG HNLRWILTFI LLFVLVCEIA EGILSDGVTE SRHLHLYMPA GMAFMAAITS 130 140 150 160 170 180 VVYYHNIETS NFPKLLIALL IYWTLAFITK TIKFVKFYDH AIGFSQLRFC LTGLLVILYG 190 200 210 220 230 240 MLLLVEVNVI RVRPFVNLLS KGTYWWMNAF IKTAHKKPID LRAIGKLPIA MRALTNYQRL 250 260 270 280 290 300 CLAFDAQARK DTQSQQGARA IWRALCHAFG RRLVLSSTFR ILADLLGFAG PLCIFGIVDH 310 320 330 340 350 360 LGKENHVFQP KTQFLGVYFV SSQEFLGNAY VLAVLLFLAL LLQRTFLQAS YYVAIETGIN 370 380 390 400 410 420 LRGAIQTKIY NKIMHLSTSN LSMGEMTAGQ ICNLVAIDTN QLMWFFFLCP NLWAMPVQII 430 440 450 460 470 480 VGVILLYYIL GVSALIGAAV IILLAPVQYF VATKLSQAQR STLEYSNERL KQTNEMLRGI 490 500 510 520 530 540 KLLKLYAWEN IFCSRVEKTR RKEMTSLRAF AVYTSISIFM NTAIPIAAVL ITFVGHVSFF 550 560 570 580 590 600 KESDFSPSVA FASLSLFHIL VTPLFLLSSV VRSTVKALVS VQKLSEFLSS AEIREEQCAP 610 620 630 640 650 660 REPAPQGQAG KYQAVPLKVV NRKRPAREEV RDLLGPLQRL TPSTDGDADN FCVQIIGGFF 670 680 690 700 710 720 TWTPDGIPTL SNITIRIPRG QLTMIVGQVG CGKSSLLLAT LGEMQKVSGA VFWNSSLPDS 730 740 750 760 770 780 EGEDPSNPER ETAADSDARS RGPVAYASQK PWLLNATVEE NITFESPFNK QRYKMVIEAC 790 800 810 820 830 840 SLQPDIDILP HGDQTQIGER GINLSGGQRQ RISVARALYQ HTNVVFLDDP FSALDVHLSD 850 860 870 880 890 900 HLMQAGILEL LRDDKRTVVL VTHKLQYLPH ADWIIAMKDG TIQREGTLKD FQRSECQLFE 910 920 930 940 950 960 HWKTLMNRQD QELEKETVME RKAPEPSQGL PRAMSSRDGL LLDEDEEEEE AAESEEDDNL 970 980 990 1000 1010 1020 SSVLHQRAKI PWRACTKYLS SAGILLLSLL VFSQLLKHMV LVAIDYWLAK WTDSALVLSP 1030 1040 1050 1060 1070 1080 AARNCSLSQE CALDQSVYAM VFTVLCSLGI ALCLVTSVTV EWTGLKVAKR LHRSLLNRII 1090 1100 1110 1120 1130 1140 LAPMRFFETT PLGSILNRFS SDCNTIDQHI PSTLECLSRS TLLCVSALAV ISYVTPVFLV 1150 1160 1170 1180 1190 1200 ALLPLAVVCY FIQKYFRVAS RDLQQLDDTT QLPLLSHFAE TVEGLTTIRA FRYEARFQQK 1210 1220 1230 1240 1250 1260 LLEYTDSNNI ASLFLTAANR WLEVRMEYIG ACVVLIAAAT SISNSLHREL SAGLVGLGLT 1270 1280 1290 1300 1310 1320 YALMVSNYLN WMVRNLADME IQLGAVKRIH TLLKTEAESY EGLLAPSLIP KNWPDQGKIQ 1330 1340 1350 1360 1370 1380 IQNLSVRYDS SLKPVLKHVN ALISPGQKIG ICGRTGSGKS SFSLAFFRMV DMFEGRIIID 1390 1400 1410 1420 1430 1440 GIDIAKLPLH TLRSRLSIIL QDPVLFSGTI RFNLDPEKKC SDSTLWEALE IAQLKLVVKA 1450 1460 1470 1480 1490 1500 LPGGLDAIIT EGGENFSQGQ RQLFCLARAF VRKTSIFIMD EATASIDMAT ENILQKVVMT 1510 1520 1530 1540 1550 AFADRTVVTI AHRVHTILSA DLVMVLKRGA ILEFDKPEKL LSQKDSVFAS FVRADK

References

[1]	"Novel splice variants of the SUR1 gene." Amagase Y., Richardson P.J., Lee K., Cox P.J. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Norway EMBL CAD54072.1. Tissue: Brain EMBL CAD54072.1.
[2]	"Identification and molecular analysis of novel splice variants of the SUR1 gene." Amagase Y. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Norway EMBL CAD54072.1. Tissue: Brain EMBL CAD54072.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ511272 mRNA. Translation: CAD54072.1.
IPI	IPI00204427.
UniGene	Rn.11187
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q70X90.
Phylogenomic databases
HOVERGEN	Q70X90.
Gene expression databases
Genevestigator	Q70X90.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. IPR000388. Sulphorea_rcpt_N. IPR000844. Surea_rcpt_1_N. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
PRINTS	PR01093. SULFNYLUR1. PR01092. SULFNYLUREAR.
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q70X90_RAT

Accession

Primary (citable) accession number: Q70X90

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)