T-cell-specific surface glycoprotein

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Unreviewed, UniProtKB/TrEMBL Q70WG0 (Q70WG0_HUMAN)

Last modified January 19, 2010. Version 39. History...

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
T-cell-specific surface glycoprotein EMBL CAD57003.1
Submitted name:
CD28 antigen (Tp44), isoform CRA_b EMBL EAW70348.1

Gene names

Name:	CD28 EMBL CAD57003.1
ORF Names:	hCG_16886 EMBL EAW70348.1

Organism

Homo sapiens (Human) EMBL CAD57003.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

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Ontologies

Gene Ontology (GO)
Biological process	T cell costimulation Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro induction of apoptosis by extracellular signals Inferred from electronic annotation. Source: Compara negative thymic T cell selection Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of interleukin-2 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of isotype switching to IgG isotypes Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	external side of plasma membrane Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara
Molecular function	protein homodimerization activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q70WG0-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 02AD85397834E57E
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FASTA

234

26,186

        10         20         30         40         50         60 
MPCGLSALIM CPKGMVAVVV AVDDGDSQAL AGNKILVKQS PMLVAYDNAV NLSCKYSYNL 

        70         80         90        100        110        120 
FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ 

       130        140        150        160        170        180 
TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY 

       190        200        210        220        230 
SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRS

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References

[1]	"New human CD28 isoforms generated by a novel splicing event in the 5'UTR." Gan S.U., Hare J., Krivoshchapov L., Hui K.M., Galea-Lauri J., Farzaneh F., Darling D. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ517504 mRNA. Translation: CAD57003.1. CH471063 Genomic DNA. Translation: EAW70348.1.
IPI	IPI00428846.
UniGene	Hs.591629
3D structure databases
HSSP	HSSP built from PDB template 1AH1 based on UniProtKB P16410.
SMR	Q70WG0. Positions 33-150.
ModBase	Search...
Protein-protein interaction databases
STRING	Q70WG0.
Proteomic databases
PRIDE	Q70WG0.
Genome annotation databases
Ensembl	ENST00000458610; ENSP00000393648; ENSG00000178562; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:1653. CD28.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG280303.
HOVERGEN	Q70WG0.
OMA	TIIHVKE.
Gene expression databases
ArrayExpress	Q70WG0.
Bgee	Q70WG0.
Family and domain databases
InterPro	IPR008093. CD28. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
PRINTS	PR01717. CD28ANTIGEN.
ProtoNet	Search...

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Entry information

Entry name

Q70WG0_HUMAN

Accession

Primary (citable) accession number: Q70WG0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information