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Protein

2-acylglycerol O-acyltransferase 1

Gene

MOGAT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycerol metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-75109. Triglyceride Biosynthesis.
UniPathwayiUPA00282.

Names & Taxonomyi

Protein namesi
Recommended name:
2-acylglycerol O-acyltransferase 1 (EC:2.3.1.22)
Alternative name(s):
Acyl CoA:monoacylglycerol acyltransferase 1
Short name:
MGAT1
Monoacylglycerol O-acyltransferase 1
Gene namesi
Name:MOGAT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3353352-acylglycerol O-acyltransferase 1PRO_0000249057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ70VZ7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008431.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011091.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ70VZ7.
KOiK14458.
OMAiSWTIWRY.
OrthoDBiEOG091G0BGQ.
TreeFamiTF314707.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q70VZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEFAPLNI PLARRLQTAA VLHWLLSFLL FAQVCLGIIV FLIIYNYWFL
60 70 80 90 100
YLPYLTWLYF DWQTPEQGGR RSEWVRNWAI WRYFKDYFPI HLIKTWDLDP
110 120 130 140 150
SHNYIFGFHP HGVLVVGAFG NFCTNYSAFK ELFPGFTSYL HVLPYWFRCP
160 170 180 190 200
LFREYLMSSG PVSVSKKSVC HVLSKEGGGN ISVIVLGGAE ESLDAHPGKF
210 220 230 240 250
TLFIRQRKGF VKIALTHGAY LVPVFSFGEN ELFKQVSNPE GSWLRNVQEK
260 270 280 290 300
LQKIMGFALP LFHARGIFQY NFGLIPYRKP IHTVVGRPIP VRQTLNPTSE
310 320 330
QIEELHQTYM EELRKLFEEH KGKYGIPENE TLIFR
Length:335
Mass (Da):39,110
Last modified:July 5, 2004 - v1
Checksum:iBDA8886BAD3BD562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534373
, AJ534374, AJ534376, AJ534375 Genomic DNA. Translation: CAD58969.2.
AJ519785 mRNA. Translation: CAD58590.2.
RefSeqiNP_001001153.1. NM_001001153.2.
UniGeneiBt.28476.

Genome annotation databases

EnsembliENSBTAT00000011091; ENSBTAP00000011091; ENSBTAG00000008431.
GeneIDi407225.
KEGGibta:407225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ534373
, AJ534374, AJ534376, AJ534375 Genomic DNA. Translation: CAD58969.2.
AJ519785 mRNA. Translation: CAD58590.2.
RefSeqiNP_001001153.1. NM_001001153.2.
UniGeneiBt.28476.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011091.

Proteomic databases

PaxDbiQ70VZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011091; ENSBTAP00000011091; ENSBTAG00000008431.
GeneIDi407225.
KEGGibta:407225.

Organism-specific databases

CTDi116255.

Phylogenomic databases

eggNOGiKOG0831. Eukaryota.
ENOG410XTG3. LUCA.
GeneTreeiENSGT00750000117391.
HOGENOMiHOG000179738.
HOVERGENiHBG065791.
InParanoidiQ70VZ7.
KOiK14458.
OMAiSWTIWRY.
OrthoDBiEOG091G0BGQ.
TreeFamiTF314707.

Enzyme and pathway databases

UniPathwayiUPA00282.
ReactomeiR-BTA-75109. Triglyceride Biosynthesis.

Gene expression databases

BgeeiENSBTAG00000008431.

Family and domain databases

InterProiIPR007130. DAGAT.
[Graphical view]
PfamiPF03982. DAGAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOGT1_BOVIN
AccessioniPrimary (citable) accession number: Q70VZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.