Q70VZ7 (MOGT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-acylglycerol O-acyltransferase 1
EC=2.3.1.22

Alternative name(s):
Acyl CoA:monoacylglycerol acyltransferase 1
Short name=MGAT1
Monoacylglycerol O-acyltransferase 1

Gene names

Name:

MOGAT1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine By similarity.
Catalytic activity	Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
Pathway	Glycerolipid metabolism; triacylglycerol biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the diacylglycerol acyltransferase family.

Ontologies

Keywords
Biological process	Glycerol metabolism Lipid metabolism Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2-acylglycerol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	2-acylglycerol O-acyltransferase 1		PRO_0000249057
Regions
	Transmembrane	24 – 44	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
Amino acid modifications
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q70VZ7 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BDA8886BAD3BD562	FASTA	335	39,110
	10 20 30 40 50 60 MKVEFAPLNI PLARRLQTAA VLHWLLSFLL FAQVCLGIIV FLIIYNYWFL YLPYLTWLYF 70 80 90 100 110 120 DWQTPEQGGR RSEWVRNWAI WRYFKDYFPI HLIKTWDLDP SHNYIFGFHP HGVLVVGAFG 130 140 150 160 170 180 NFCTNYSAFK ELFPGFTSYL HVLPYWFRCP LFREYLMSSG PVSVSKKSVC HVLSKEGGGN 190 200 210 220 230 240 ISVIVLGGAE ESLDAHPGKF TLFIRQRKGF VKIALTHGAY LVPVFSFGEN ELFKQVSNPE 250 260 270 280 290 300 GSWLRNVQEK LQKIMGFALP LFHARGIFQY NFGLIPYRKP IHTVVGRPIP VRQTLNPTSE 310 320 330 QIEELHQTYM EELRKLFEEH KGKYGIPENE TLIFR

References

[1]	"Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals." Winter A., van Eckeveld M., Bininda-Emonds O.R.P., Habermann F.A., Fries R. Cytogenet. Genome Res. 102:42-47(2003) [PubMed: 14970677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ534373 , AJ534374, AJ534376, AJ534375 Genomic DNA. Translation: CAD58969.2. AJ519785 mRNA. Translation: CAD58590.2.
IPI	IPI00697239.
RefSeq	NP_001001153.1. NM_001001153.2.
UniGene	Bt.28476.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q70VZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000011091; ENSBTAP00000011091; ENSBTAG00000008431.
GeneID	407225.
KEGG	bta:407225.
Organism-specific databases
CTD	116255.
Phylogenomic databases
eggNOG	maNOG13037.
GeneTree	ENSGT00550000074276.
HOVERGEN	HBG065791.
InParanoid	Q70VZ7.
OrthoDB	EOG4BP1C4.
PhylomeDB	Q70VZ7.
Family and domain databases
InterPro	IPR007130. DAGAT. [Graphical view]
KO	K14458.
PANTHER	PTHR12317. DAGAT. 1 hit.
Pfam	PF03982. DAGAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOGT1_BOVIN

Accession

Primary (citable) accession number: Q70VZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program